High-efficiency passive micromixer using three-dimensional printed molds

Valijam, Shayan; Veladi, Hadi; Baghban, Hamed; Zargari, Siavash

doi:10.1117/1.jmm.17.2.025002

Cited by 6 publications

(2 citation statements)

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“…They concluded that mixing effect depends on the design of electro-osmotic mixer along with the position and orientation of electrodes installed inside the chamber. Valijam et al 22 also worked on T-and Zigzag-shaped mixers. Their detail analysis based on finite element method (FEM) and experimental on micromixers with 1-8 cm length concluded 95% mixing efficiency at low flow rate value of 2 Â 10 À8 m 3 =s.…”

Section: Introductionmentioning

confidence: 99%

Optimal parametric mixing analysis of active and passive micromixers using Taguchi method

Shah

Jeon

Ali

et al. 2019

Proceedings of the Institution of Mechanical Engineers, Part E:

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Mixing of fluids flowing through channels and chambers is a crucial step in chemical and biochemical reactions inside microfluidic devices due to laminar flow because of small size channel and chamber dimensions. Mixing can be enhanced by passive or active mechanism which makes convection dominant over diffusion. To address this challenge, the study proposes three novel mixing designs: passive mixer, active mixer and a combination of active and passive mixing. These designs mixing performance has been studied by numerical simulation using COMSOL 5.3. According to the preliminary results of the study, pure active micromixer design has superior mixing ability. The mixing ability was proved by concentration line plots, concentration contours and videos. In order to further optimize the mixing index of the pure active micromixer, Taguchi method is applied against various input parametric values for micromixer such as frequency, voltage and velocity. The velocity is required for two fluids to flow, while frequency and voltages are for providing an external energy for active mixing. A total of nine cases were analyzed; the two best cases out of nine were selected for comparing mixing index line plots. The result of the study conclude that pure active micro-mixer at an optimal set of parameters, frequency of 10 Hz, velocity of 0.05 mm s–1 and voltage of 0.5 V achieved 99.6% mixing index at t = 0.2 s.

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Section: Introductionmentioning

confidence: 99%

Optimal parametric mixing analysis of active and passive micromixers using Taguchi method

Shah

Jeon

Ali

et al. 2019

Proceedings of the Institution of Mechanical Engineers, Part E:

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“…A variety of approaches have been pursued to minimize the influence of RTD on polymer structure (Figure B). − Guironnet and co-workers exploited a Taylor dispersion effect that resulted in plug-like flow of even viscous polymerizations . While this worked well to precisely control the addition of discrete building blocks for bottle-brush copolymer synthesis, the approach relies on small diameter tubing and long reaction times.…”

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confidence: 99%

Polymerizations in Continuous Flow: Recent Advances in the Synthesis of Diverse Polymeric Materials

2020

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The number of reports using continuous flow technology in tubular reactors to perform precision polymerizations has grown enormously in recent years. Flow polymerizations allow highly efficient preparation of polymers exhibiting well-defined molecular characteristics, and has been applied to a slew of monomers and various polymerization mechanisms, including anionic, cationic, radical, and ring-opening. Polymerization conducted in continuous flow offers several distinct advantages, including improved efficiency, reproducibility, and enhanced safety for exothermic polymerizations using highly toxic components, high pressures, and high temperatures. The further development of this technology is thus of relevance for many industrial polymerization processes. While much progress has been demonstrated in recent years, opportunities remain for increasing the compositional and architectural complexity of polymeric materials synthesized in a continuous fashion. Extending the reactor processing principles that have heretofore been focused on optimizing homopolymerization to include multisegment block copolymers, particularly from monomers that propagate via incompatible mechanisms, represents a major challenge and coveted target for continuous flow polymerization. Likewise, the spatial and temporal control of reactivity afforded by flow chemistry has and will continue to enable the production of complex polymeric architectures. This Viewpoint offers a brief background of continuous flow polymerization focused primarily on tubular (micro)reactors and includes selected examples that are relevant to these specific developments.

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Design of a low-voltage dielectrophoresis lab-on-the chip to separate tumor and blood cells

Valijam

Salehi

Andersson

2023

Microfluid Nanofluid

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In this paper, we design and propose a compact label-free microfluidic lab-on-a-chip device to separate circulating tumor cells (CTCs) from red blood cells (RBCs) at low voltage to minimize cell damage. With the aim of developing a mm-long device to perform cell separation, we used 3D finite element simulation modeling and investigated separation efficiency for different electrode configurations, electrode shapes, and channel heights. Our results show that configuring the electrodes as two arrays, consisting of only five pairs of top and bottom planar electrodes shifted relative to each other and energized with ± 6 V at 70 kHz, generates sufficient non-uniform electric fields to separate CTCs and RBCs in a 2 mm long channel. The advantage of the proposed design is the simplicity of the electrode arrangement and that the electrodes do not cover the central part of the channel, thus allowing for brightfield imaging of the channel. In addition, the low voltage needed and the 50 µm high channel reduce the Joule heating effect and improve the device's separation and throughput efficiency. We suggest that the proposed design would be effective for separating CTCs and RBCs and, thus, used as a device for the early detection of CTCs.

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High-efficiency passive micromixer using three-dimensional printed molds

Cited by 6 publications

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Optimal parametric mixing analysis of active and passive micromixers using Taguchi method

Optimal parametric mixing analysis of active and passive micromixers using Taguchi method

Polymerizations in Continuous Flow: Recent Advances in the Synthesis of Diverse Polymeric Materials

Design of a low-voltage dielectrophoresis lab-on-the chip to separate tumor and blood cells

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