High efficiency upconversion nanophosphors for high-contrast bioimaging

Alkahtani, Masfer; Alghannam, Fahad; Sánchez, Carlos J.; Gomes, Carmen; Liang, Hong; Hemmer, Philip

doi:10.1088/0957-4484/27/48/485501

Cited by 35 publications

(20 citation statements)

References 29 publications

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“…The larger size than expected was likely due to the high temperature treatment of 1000 0 C for 10 min. To avoid this problem in the future, we note that silica-gel encapsulation has been reported to prevent the nanoparticle size from increasing during high temperature annealing [42][43][44]. The TEM and optical characterization of YVO 4 : Er 3+ , Yb 3+ @Nd 3+ were discussed in detail in previous work [36].…”

Section: Resultsmentioning

confidence: 99%

“…2.1. Synthesis of (Gd/Y)VO 4 : Yb, Er@Nd core/shell nanoparticles Briefly, for both systems, core nanoparticles were prepared following a hydrothermal synthesis procedure described in [42][43][44]. Their synthesis is described below.…”

Section: Methodsmentioning

confidence: 99%

“…Interestingly, other studies show that the vanadate ion can interact with glucose in a way that can be used to control blood sugar [39][40][41][42]. In addition to being naturally glucose-sensitive, vanadate crystals like YVO 4 and GdVO 4 have shown high upconversion efficiency and good photostability in water, as reported in [35,[43][44][45]].…”

Section: Introductionmentioning

confidence: 98%

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Lanthanide ions doped in vanadium oxide for sensitive optical glucose detection

Talib¹,

Alkahtani²,

Jiang³

et al. 2018

Opt. Mater. Express

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Blood glucose monitoring is essential to avoid the unwanted consequences of glucose level fluctuations. Optical monitors are of special interest because they can be non-invasive. Among optical glucose sensors, fluorescent upconversion nanoparticles (UCNPs) have the advantage of good photostability, low toxicity, and exceptional autofluorescence suppression. However, to sense glucose, UCNPs normally need surface functionalization, and this can be easily affected by other factors in biological systems, and may also affect their ability for real-time sensing of both increasing and decreasing glucose levels. Here, we report YVO4 : Yb3+, Er3+@Nd3+core/shell UCNPs with Nd and Yb shell and GdVO4 : Yb3+, Er3+@Nd3+ core/shell UCNPs with Nd and Yb shell that show sensitive, reversible, and selective optical glucose detection without the need for any surface functionalization or modifications. Disciplines Biology and Biomimetic Materials | Biomechanical Engineering | Mechanical EngineeringComments Abstract: Blood glucose monitoring is essential to avoid the unwanted consequences of glucose level fluctuations. Optical monitors are of special interest because they can be non-invasive. Among optical glucose sensors, fluorescent upconversion nanoparticles (UCNPs) have the advantage of good photostability, low toxicity, and exceptional autofluorescence suppression. However, to sense glucose, UCNPs normally need surface functionalization, and this can be easily affected by other factors in biological systems, and may also affect their ability for real-time sensing of both increasing and decreasing glucose levels. Here, we report YVO 4 : Yb 3+ , Er 3+ @Nd 3+ core/shell UCNPs with Nd and Yb shell and GdVO 4 : Yb 3+ , Er 3+ @Nd 3+ core/shell UCNPs with Nd and Yb shell that show sensitive, reversible, and selective optical glucose detection without the need for any surface functionalization or modifications.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Lanthanide ions doped in vanadium oxide for sensitive optical glucose detection

Talib¹,

Alkahtani²,

Jiang³

et al. 2018

Opt. Mater. Express

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“…Rare-earth (RE)-doped upconversion luminescence nanoparticles (UCLNPs) are an important kind of functional nanomaterial. − They exhibit excellent performance and have evoked much attention due to their wide promising applications in temperature sensors, − solar energy conversion, , biomedical imaging, − biomass detection, medical tracers, , photodynamic therapy, ,, drug-targeted delivery, photocatalysis, , anticounterfeiting, , etc. Nano NaYF 4 :RE is an outstanding representative of these nanomaterials, , although the relatively poor UCL performance is still the main obstacle for their application.…”

Section: Introductionmentioning

confidence: 99%

Enhancement of Upconversion Luminescence by the Construction of a 3Yb-Er-Hf Sublattice Energy Cluster and Surface Defect Elimination

Han

Lin

et al. 2022

Inorg. Chem.

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Nanotetragonal LiYF4:RE (Tm,Er,Ho) is a kind of excellent upconversion luminescence (UCL) material potentially used in many fields, while the enhancement of UC emission and regulation of luminescence lifetime are still a challenge. Herein, a strategy was reported to enhance UCL performance with the aid of the construction of a 3Yb-Er-Hf sublattice energy cluster with the introduction of Hf4+ and the interception of surface defect fluorescence quenching. UCL was obviously decreased by Hf4+ doping without surface defect elimination, but after the interception of surface defect quenching, UCL was dramatically enhanced more than 300-fold with an Er3+/Hf4+ mole ratio of 1:1. The contribution of UCL enhancement by the construction of a 3Yb-Er-Hf sublattice energy cluster is about 1.5 times of the sample without energy cluster construction. Interestingly, the lifetime of UCL can also be regulated by this strategy. According to the results of systematical microstructure analyses and UCL performance behaviors examined by X-ray powder diffraction (XRD), small-angle X-ray scattering (SAXS), transmission electron microscopy (TEM), nuclear magnetic resonance (NMR), and fluorescence spectrophotometry (FS) methods, the possible mechanism of UCL enhancement was proposed. This work may be an inspiration for researchers to design and develop high-performance UCL nanomaterials.

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“…Lanthanide-doped (Ln 3+ , such as Yb 3+ , Tm 3+ , Er 3+ , Ho 3+ ) upconversion nanoparticles (UCNPs) are a kind of emerging biological materials. − Upconversion luminescence (UCL) is anti-Stokes emission, which can convert to ultraviolet (UV) or visible (vis) emission via absorbing near-infrared (NIR) light. UCNPs based on their unique properties have been considered an important material for bioimaging applications. − Biological fluorescent probes based on lanthanide-doped UCNPs can be excited using 750–1000 nm NIR light. − Therefore, UCNPs show little absorption to biological components such as lipids and hemoglobin, which significantly improves deep tissue penetration and the signal-to-noise ratio. − It is challenging to develop a fluorescent probe with high UCL efficiency and good stability for bioimaging in living cells. In fact, the host has an important influence on UCL properties. − An oxide host has high chemical stability and thermal stability compared to fluorides.…”

Section: Introductionmentioning

confidence: 99%

Low Toxicity, High Resolution, and Red Tissue Imaging in the Vivo of Yb/Tm/GZO@SiO₂ Core–Shell Upconversion Nanoparticles

Bai

Wang

et al. 2020

ACS Omega

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Lanthanide-doped upconversion nanoparticles (UCNPs) have attracted great attention in bioimaging applications. However, the stability and resolution of bioimaging based on UCNPs should be further improved. Herein, we synthesized SiO 2coated Ga(III)-doped ZnO (GZO) with lanthanide ion Yb(III) and Tm(III) (Yb/Tm/GZO@SiO 2 ) UCNPs, which realized red fluorescence imaging in heart tissue. With increasing injection concentrations of Yb/Tm/GZO@SiO 2 (1−10 mg/kg), the red fluorescence imaging intensity of heart tissue gradually increased. Moreover, the experimental results of toxicity in vitro and histological assessments of representative organs in vivo were studied, indicating that Yb/Tm/GZO@SiO 2 UCNPs had low biological toxicity. These results proved that Yb/Tm/GZO@SiO 2 can be used as a probe for fluorescence imaging in vivo.

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High efficiency upconversion nanophosphors for high-contrast bioimaging

Cited by 35 publications

References 29 publications

Lanthanide ions doped in vanadium oxide for sensitive optical glucose detection

Lanthanide ions doped in vanadium oxide for sensitive optical glucose detection

Enhancement of Upconversion Luminescence by the Construction of a 3Yb-Er-Hf Sublattice Energy Cluster and Surface Defect Elimination

Low Toxicity, High Resolution, and Red Tissue Imaging in the Vivo of Yb/Tm/GZO@SiO₂ Core–Shell Upconversion Nanoparticles

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High efficiency upconversion nanophosphors for high-contrast bioimaging

Cited by 35 publications

References 29 publications

Lanthanide ions doped in vanadium oxide for sensitive optical glucose detection

Lanthanide ions doped in vanadium oxide for sensitive optical glucose detection

Enhancement of Upconversion Luminescence by the Construction of a 3Yb-Er-Hf Sublattice Energy Cluster and Surface Defect Elimination

Low Toxicity, High Resolution, and Red Tissue Imaging in the Vivo of Yb/Tm/GZO@SiO2 Core–Shell Upconversion Nanoparticles

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Low Toxicity, High Resolution, and Red Tissue Imaging in the Vivo of Yb/Tm/GZO@SiO₂ Core–Shell Upconversion Nanoparticles