Using several-mJ energy pulses from a high-repetition rate ( 1 ⁄2 kHz), ultrashort (35 fs) pulsed laser interacting with a ∼ 10 µm diameter stream of free-flowing heavy water (D 2 O), we demonstrate a 2.45 MeV neutron flux of 10 5 /s. Operating at high intensity (of order 10 19 Wcm −2 ), laser pulse energy is efficiently absorbed in the pre-plasma, generating energetic deuterons. These collide with deuterium nuclei in both the bulk target and the large volume of low density D 2 O vapor surrounding the target to generate neutrons through d (d, n) 3 He reactions. The neutron flux, as measured by a calibrated neutron bubble detector, increased as the laser pulse energy was increased from 6 mJ to 12 mJ. A quantitative comparison between the measured flux and results derived from 2D particle-in-cell simulations show comparable neutron fluxes for similar laser characteristics to the experiment. The simulations reveal that there are two groups of deuterons; forward moving deuterons generate D−D fusion reactions in the D 2 O stream and act as a point source of neutrons, while backward moving deuterons propagate through the low-density D 2 O vapor filled chamber and yield a volumetric source of neutrons.Energetic neutrons have numerous applications in many fields, including medicine 1 , homeland security 2 , and material science 3 . Conventional fast neutron sources include deuterium−deuterium (D−D) and deuteriumtritium (D−T) fusion generators, as well as light-ion, photoneutron and spallation sources. Laser plasma interactions in the relativistic regime can also generate charged particles and subsequently accelerate them to energies high enough to trigger nuclear fusion reactions, resulting in neutron production [4][5][6][7][8][9][10][11][12][13][14][15][16] . Recent advances in ultra-high power laser technology now enable tabletop scale systems, which may be further reduced in size for use as drivers for portable neutron generators in the future. One of the methods for neutron production is through the acceleration of high-energy ions (keV-MeV) impinging upon an appropriate converter target, such as deuterated plastic. Typically, thin solid targets are used in these experiments to accelerate deuterons.Using solid targets in the form of a thin (1µm) foil has some drawbacks for high repetition-rate (>kHz) operation; for example, one has to replace the target after each shot. To resolve target life-time issues, fast target replacement schemes have been introduced by some groups 8,15,[17][18][19] . In particular, using ∼ 100 mJ of pulse energy at 10 Hz repetition-rate, Ditmire et. al. 8 used deuterium clusters, which were rapidly heated by the laser pulse (on a femtosecond time scale) and launched few a) Now at Physics Department, Lancaster University, UK keV deuterons to drive D−D fusion reactions.In this Letter, we report the production of neutrons using a high repetition-rate ( 1 ⁄2 kHz) femtosecond laser at high intensities (> 10 19 Wcm −2 for vacuum focus) but low pulse energies (several-mJ) interacting with a heavy...