High energy X-ray radiation sensitive scintillating materials for medical imaging, cancer diagnosis and therapy

Lu, Lu; Sun, Mingzi; Lu, Qimiao; Wu, Tong; Huang, Bolong

doi:10.1016/j.nanoen.2020.105437

Cited by 141 publications

(83 citation statements)

References 262 publications

(227 reference statements)

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“…The signal contrast can be translated by scintillator screen into difference of RL intensity, finally realizing optical imaging. [ 40,51–56 ] As depicted in Figure 4b, one capsule with a metal spring inside was used for imaging. The inner spring cannot be observed under daylight, while the metal spring can be imaged clearly by the Mn‐based scintillator screen when exposed to X‐ray due to the stronger X‐ray attenuation of inside metal spring than that of the capsule.…”

Section: Resultsmentioning

confidence: 99%

Highly Emissive and Stable Five‐Coordinated Manganese(II) Complex for X‐Ray Imaging

Meng

Zhu

et al. 2021

Laser & Photonics Reviews

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Nowadays, the development of X‐ray imaging has promoted the demand for new‐type scintillators, among which low‐toxic manganese(II) complexes have attracted burgeoning research interest. Herein, a highly stable manganese(II) complex with peculiar five‐coordinated modes is reported, which exhibits strong yellow emission peaked at 583 nm originating from d‐d transition of Mn2+ with high photoluminescence quantum yield (PLQY) up to 93%. The five‐coordinated manganese(II) complex has been rarely reported so far which is an innovative spot in the field of photofunctional metal complex. Thanks to the high PLQY and relatively large stokes shift, the manganese(II) complex yields bright yellow emission under low‐dose X‐ray irradiation and delivers excellent linear response to X‐ray, highlighting its suitability for X‐ray contrast imaging. Based on this, highly resolved X‐ray imaging is successfully achieved that can meet the requirements of many application scenarios. In addition, this manganese(II) complex demonstrates excellent radiation hardness, humidity resistance, and heat stability, indicating the application potential of scintillators in harsh environments. This research not only provides guidance for the design and fabrication of highly luminescent manganese(II)‐based complexes, but also demonstrates the potential of manganese(II)‐based complexes as scintillators for X‐ray imaging technology.

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Section: Resultsmentioning

confidence: 99%

Highly Emissive and Stable Five‐Coordinated Manganese(II) Complex for X‐Ray Imaging

Meng

Zhu

et al. 2021

Laser & Photonics Reviews

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“…X-ray diagnosis is among the oldest traditional methods allowing for tumor identification. It is based on the different densities of tumor and healthy tissues [ 10 ]. Colonoscopy is a rather useful diagnosis method for the identification of colorectal cancer as well as for its non-invasive treatment [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Polymer Nanoparticles and Nanomotors Modified by DNA/RNA Aptamers and Antibodies in Targeted Therapy of Cancer

2021

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Polymer nanoparticles and nano/micromotors are novel nanostructures that are of increased interest especially in the diagnosis and therapy of cancer. These structures are modified by antibodies or nucleic acid aptamers and can recognize the cancer markers at the membrane of the cancer cells or in the intracellular side. They can serve as a cargo for targeted transport of drugs or nucleic acids in chemo- immuno- or gene therapy. The various mechanisms, such as enzyme, ultrasound, magnetic, electrical, or light, served as a driving force for nano/micromotors, allowing their transport into the cells. This review is focused on the recent achievements in the development of polymer nanoparticles and nano/micromotors modified by antibodies and nucleic acid aptamers. The methods of preparation of polymer nanoparticles, their structure and properties are provided together with those for synthesis and the application of nano/micromotors. The various mechanisms of the driving of nano/micromotors such as chemical, light, ultrasound, electric and magnetic fields are explained. The targeting drug delivery is based on the modification of nanostructures by receptors such as nucleic acid aptamers and antibodies. Special focus is therefore on the method of selection aptamers for recognition cancer markers as well as on the comparison of the properties of nucleic acid aptamers and antibodies. The methods of immobilization of aptamers at the nanoparticles and nano/micromotors are provided. Examples of applications of polymer nanoparticles and nano/micromotors in targeted delivery and in controlled drug release are presented. The future perspectives of biomimetic nanostructures in personalized nanomedicine are also discussed.

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“…Among them, scintillators are widely used in medical diagnosis, computed tomography, non-destructive inspections, security, nuclear radiation detection, etc. Scintillators are known as radiosensitive luminescent materials that can convert high-energy photons (X-rays or γ-rays) to low-energy photons or electrical charges [ 13 ]. Some conventional scintillators, such as Lu 3 Al 5 O 12 :Ce 3+ , require very high temperature sintering and long annealing time [ 14 , 15 ], while modern scintillating materials (mostly lead halide elpasolite perovskites structure

) exhibit low X-ray light yield, instability, and toxicity [ 12 , 13 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

“…Scintillators are known as radiosensitive luminescent materials that can convert high-energy photons (X-rays or γ-rays) to low-energy photons or electrical charges [ 13 ]. Some conventional scintillators, such as Lu 3 Al 5 O 12 :Ce 3+ , require very high temperature sintering and long annealing time [ 14 , 15 ], while modern scintillating materials (mostly lead halide elpasolite perovskites structure

) exhibit low X-ray light yield, instability, and toxicity [ 12 , 13 , 16 ]. Therefore, finding novel scintillating materials, which require low-dose irradiation, high stability, and high spatial resolution, and are lead-free, has become extremely urgent.…”

Section: Introductionmentioning

confidence: 99%

Effect of Ceramic Formation on the Emission of Eu3+ and Nd3+ Ions in Double Perovskites

et al. 2021

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Herein, the structure, morphology, as well as optical properties of the powder and ceramic samples of Ba2MgWO6 are presented. Powder samples were obtained by high temperature solid-state reaction, while, for the ceramics, the SPS technique under 50-MPa pressure was applied. The morphology of the investigated samples showed some agglomeration and grains with a submicron size of 490–492 µm. The theoretical density and relative density of ceramics were calculated using the Archimedes method. The influence of sample preparation on the position, shape, and character of the host, as well as dopants emission was investigated. Sample sintering enhances regular emission of WO6 groups causing a blue shift of Ba2MgWO6 emission. Nonetheless, under X-ray excitation, only the green emission of inversion WO6 group was detected. For the ceramic doped with Eu3+ ions, the emission of both host and dopant was detected. However, for the powder efficient host to activator energy, the transfer process occurred, and only the magnetic dipole emission of Eu3+ was detected. The intensity of Nd3+ ions of Ba2MgWO6 powder sample is five times higher than for the ceramic. The sintering process reduces inversion defects and creates a highly symmetrical site of neodymium ions. The emission of Ba2MgWO6:Nd3+ consists of transitions from the 4F3/2 excited level to the 4IJ multiplet states with the dominance of the 4F3/2→4I11/2 one. The spectroscopic quality parameter and branching ratio of Nd3+ emission are presented.

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High energy X-ray radiation sensitive scintillating materials for medical imaging, cancer diagnosis and therapy

Cited by 141 publications

References 262 publications

Highly Emissive and Stable Five‐Coordinated Manganese(II) Complex for X‐Ray Imaging

Highly Emissive and Stable Five‐Coordinated Manganese(II) Complex for X‐Ray Imaging

Polymer Nanoparticles and Nanomotors Modified by DNA/RNA Aptamers and Antibodies in Targeted Therapy of Cancer

Effect of Ceramic Formation on the Emission of Eu3+ and Nd3+ Ions in Double Perovskites

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