High Eosinophil Cationic Protein Level in Asthmatic Patients  with "Heat" Zheng

Hsu, Ching-Hsaing; Yu, Min‐Chien; Lee, Chang-Hsien; Lee, Tsung-Cheng; Yang, Shumei

doi:10.1142/s0192415x03000965

Cited by 31 publications

(22 citation statements)

References 15 publications

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“…“Mai-Men-Dong” was the second most commonly used single herb to “nourish yin and moisten dryness”; it can down-regulate mRNA expression of TGF-β1 and has potential antioxidant effects36. “Sheng-Di-Huang” can “enrich yin and clear heat,” and it also reduces eosinophil cationic proteins levels, which are positively correlated with “heat zheng”37 and has anti-inflammatory properties38. “Tian-Hua-Fen” can “clear heat and engender liquid,” and it can inhibit nitric oxide activity and elevate anti-inflammatory effects39.…”

Section: Discussionmentioning

confidence: 99%

The Core Pattern Analysis on Chinese Herbal Medicine for Sjögren's syndrome: A Nationwide Population-Based Study

Chang

Chu

Wei

et al. 2015

Sci Rep

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This large-scale survey aimed to evaluate frequencies and patterns of Chinese herbal medicine (CHM) used for Sjögren's syndrome (SS) in Taiwan by analyzing the National Health Insurance Research Database (NHIRD) for cases in which CHM was used as an alternative therapy to Western medicine for improving patients' discomforts. We analyzed cases of SS principal diagnosis (ICD-9:710.2) with a catastrophic illness certificate (CIC) in traditional Chinese medicine (TCM) outpatient clinics from three cohorts of the Longitudinal Health Insurance Database (LHID) in the NHIRD between 2002 and 2011. CHM prescription patterns for SS were evaluated from claimed visitation files and corresponding prescription files. There were 15,914 SS patients with CIC (SS/CIC), and we found only 130 SS/CIC cases visiting TCM clinics in LHID2000, 133 in LHID2005, and 126 in LHID2010. After removing duplicate data, 366 SS/CIC and 4,867 visits were analyzed. The 50–59 year age group showed the highest ratio (29.51%) in both women and men. “Qi-Ju-Di-Huang-Wan” and “Xuan-Shen” (Scrophularia ningpoensis Hemsl.) was the most commonly used formula and single herb, respectively. “Qi-Ju-Di-Huang-Wan, Gan-Lu-Yin, Xuan-Shen, Mai-Men-Dong (Ophiopogon japonicus (L. f.) Ker-Gawl.), and Sheng-Di-Huang (raw Rehmannia glutinosa Libosch)” were the core pattern prescriptions in treating SS/CIC.

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Section: Discussionmentioning

confidence: 99%

The Core Pattern Analysis on Chinese Herbal Medicine for Sjögren's syndrome: A Nationwide Population-Based Study

Chang

Chu

Wei

et al. 2015

Sci Rep

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“…Heat syndrome (Zheng) is a basic concept in CAM, which may can be represented as symptoms like erythema, flushed face, high fever, red tongue and so on [18]. Heat syndrome is one of major signs of AD in CAM [17], and generally corresponds to inflammation and infection in neuro-endocrine immune system of western medicine [19].…”

Section: Introductionmentioning

confidence: 99%

Douchi (fermented Glycine max Merr.) alleviates atopic dermatitis-like skin lesions in NC/Nga mice by regulation of PKC and IL-4

Jung

Ahn

Park

et al. 2016

BMC Complement Altern Med

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BackgroundDouchi (fermented Glycine max Merr.) is produced from fermented soybeans, which is widely used in traditional herbal medicine. In this study, we investigated whether Douchi attenuates protein kinase C (PKC) and interleukin (IL)-4 response and cutaneous inflammation in Atopic dermatitis (AD)-like NC/Nga mice.MethodsTo induce AD-like skin lesions, D. farinae antigen was applied to the dorsal skin of 3-week-old NC/Nga mice. After inducing AD, Douchi extract was administered 20 mg/kg daily for 3 weeks to the Douchi-treated mice group. We identified the changes of skin barrier and Th2 differentiation through PKC and IL-4 by immunohistochemistry.ResultsDouchi treatment of NC/Nga mice significantly reduced clinical scores (p < 0.01) and histological features. The levels of PKC and IL-4 were significantly reduced in the Douchi-treated group (p < 0.01). The reduction of IL-4 and PKC led to decrease of inflammatory factors such as substance P, inducible nitric oxide synthase (iNOS) and Matrix metallopeptidase 9 (MMP-9) (all p < 0.01). Douchi also down-regulated Th1 markers (IL-12, TNF-α) as well as Th2 markers (IL-4, p-IκB) (p < 0.01).ConclusionDouchi alleviates AD-like skin lesions through suppressing of PKC and IL-4. These results also lead to diminish levels of substance P, iNOS and MMP-9 in skin lesions. Therefore, Douchi may have potential applications for the prevention and treatment of AD.

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“…In fact, the authors of several earlier studies [15,16,17,18,19,20,21] have reported that there are relationships between leukocytic changes and heat stimulus. In particular, Resnik et al [21] concluded that heat stress is related to degranulation of the basophil leukocytes.…”

Section: Resultsmentioning

confidence: 99%

Inferring Genes and Biological Functions That Are Sensitive to the Severity of Toxicity Symptoms

Kim¹,

Shin²

2017

IJMS

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The effective development of new drugs relies on the identification of genes that are related to the symptoms of toxicity. Although many researchers have inferred toxicity markers, most have focused on discovering toxicity occurrence markers rather than toxicity severity markers. In this study, we aimed to identify gene markers that are relevant to both the occurrence and severity of toxicity symptoms. To identify gene markers for each of four targeted liver toxicity symptoms, we used microarray expression profiles and pathology data from 14,143 in vivo rat samples. The gene markers were found using sparse linear discriminant analysis (sLDA) in which symptom severity is used as a class label. To evaluate the inferred gene markers, we constructed regression models that predicted the severity of toxicity symptoms from gene expression profiles. Our cross-validated results revealed that our approach was more successful at finding gene markers sensitive to the aggravation of toxicity symptoms than conventional methods. Moreover, these markers were closely involved in some of the biological functions significantly related to toxicity severity in the four targeted symptoms.

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High Eosinophil Cationic Protein Level in Asthmatic Patients with "Heat" Zheng

Cited by 31 publications

References 15 publications

The Core Pattern Analysis on Chinese Herbal Medicine for Sjögren's syndrome: A Nationwide Population-Based Study

The Core Pattern Analysis on Chinese Herbal Medicine for Sjögren's syndrome: A Nationwide Population-Based Study

Douchi (fermented Glycine max Merr.) alleviates atopic dermatitis-like skin lesions in NC/Nga mice by regulation of PKC and IL-4

Inferring Genes and Biological Functions That Are Sensitive to the Severity of Toxicity Symptoms

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