High ethanol consumption as risk factor for intracerebral hemorrhage in young and middle-aged people.

Monforte, R.; Estruch, Ramón; Graus, Francesc; Nicolás, Josep M.; Urbano-Márquez, Á

doi:10.1161/01.str.21.11.1529

Cited by 85 publications

(45 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…3,7,28,29 One study reported that this association is more significant with lobar ICH. 30 Many studies have reported a high rate of hypertension among cases of ICH, 8,[31][32][33][34][35] and several reported that the rate was not significantly different by location of ICH. 24,35 Few studies have controlled for the presence of other risk factors and demographic variables that may affect the rate of hypertension.…”

Section: Lobar Ichmentioning

confidence: 99%

Genetic and Environmental Risk Factors for Intracerebral Hemorrhage

Woo

Sauerbeck

Kissela

et al. 2002

Stroke

398

296

View full text Add to dashboard Cite

Background and Purpose-Intracerebral hemorrhage (ICH) has a 30-day mortality rate of 40% to 50% and lacks a proven treatment. We report a preplanned, midpoint analysis of the first population-based, case-control study that examines both genetic and environmental risk factors of ICH. Methods-We prospectively identified cases of hemorrhagic stroke at all 16 hospitals in the Greater Cincinnati/Northern Kentucky region. All cases underwent medical record and neuroimaging review. Cases enrolled in the direct interview and genetic sampling arm of the study were matched to population-based control subjects by age, race, and sex. Multivariable logistic regression was performed to identify significant independent risk factors. Results-We enrolled 188 cases of ICH (67 lobar, 121 nonlobar) and 366 control subjects in the direct interview arm of the study. Significant independent risk factors for lobar ICH included the presence of an apolipoprotein E2 or E4 allele, frequent alcohol use, prior stroke, and first-degree relative with ICH. Significant independent risk factors for nonlobar ICH were hypertension, prior stroke, and first-degree relative with ICH. An increasing level of education was associated with a decreased risk of nonlobar ICH. The attributable risk of apolipoprotein E2 or E4 for lobar ICH was 29%, and the attributable risk of hypertension for nonlobar ICH was 54%. Conclusions-There is significant epidemiological evidence that the pathophysiology of ICH varies by location. We estimate that a third of all cases of lobar ICH are attributable to possession of an apolipoprotein E4 or E2 allele and that half of all cases of nonlobar ICH are attributable to hypertension.

show abstract

Section: Lobar Ichmentioning

confidence: 99%

Genetic and Environmental Risk Factors for Intracerebral Hemorrhage

Woo

Sauerbeck

Kissela

et al. 2002

Stroke

398

296

View full text Add to dashboard Cite

show abstract

“…T he large number of cohort studies showed an increased risk of hemorrhagic stroke among male heavy drinkers, [1][2][3][4][5][6][7][8][9][10] and reduced risk of ischemic stroke 9 -11 and coronary heart disease [12][13][14][15][16][17] among male light-to-moderate drinkers.…”

mentioning

confidence: 99%

Alcohol Consumption and Mortality From Stroke and Coronary Heart Disease Among Japanese Men and Women

Ikehara

Iso

Toyoshima

et al. 2008

Stroke

116

View full text Add to dashboard Cite

Background and Purpose-Previous studies have demonstrated the association between alcohol consumption and cardiovascular mortality. However, the sex-specific association between alcohol consumption and mortality from stroke and coronary heart disease remains unclear. Methods-Between 1988 and 1990, 34 776 men and 48 906 women aged 40 to 79 years completed a self-administered questionnaire including information about alcohol consumption. They were followed-up for a median duration of 14.2 years. Results-Of the 83 682 respondents, 1628 died from stroke and 736 died from coronary heart disease. For men, heavy drinking (Ն46.0 g ethanol/day) was associated with increased mortality from total, hemorrhagic, and ischemic strokes, whereas light-to-moderate drinking was associated with reduced mortality from total cardiovascular disease, compared with not drinking. The respective multivariable hazard ratios (95% CI) were 1.48 (1.22 to 1.80) for total stoke, 1.67 (1.17 to 2.38) for hemorrhagic stroke, 1.35 (1.04 to 1.75) for ischemic stroke, and 0.88 (0.78 to 1.00) for total cardiovascular disease. Women who were heavy drinkers (Ն46.0 g ethanol/day) showed increased mortality from coronary heart disease, and there was reduced mortality from total cardiovascular disease for drinkers of 0.1 to 22.9 g ethanol per day compared with mortality for nondrinkers. The respective multivariable hazard ratios (95% CI) for the 2 categories of drinkers were 4.10 (1.63 to 10.3) and 0.75 (0.62 to 0.91). Conclusions-Heavy alcohol consumption is associated with increased mortality from total stroke, particularly hemorrhagic stroke, and total cardiovascular disease for men, and from coronary heart disease for women, whereas light-to-moderate drinking may be associated with reduced mortality from cardiovascular disease for both sexes.

show abstract

“…Alcohol consumption is viewed as a risk factor in ischemic stroke by several authors. 8,9 In the study only four patients were habituated to use of alcohol. Large sample size is necessary to establish the role of alcoholism as a risk factor in young stroke.…”

Section: Resultsmentioning

confidence: 99%

A Cl Inical Study of Stroke in Young in a Teaching Hospital

Jacob¹,

Sreekumar²,

Paul³

2014

jemds

View full text Add to dashboard Cite

Stroke is defined as rapid onset focal neurological deficit resulting from disease of cerebral vasculature and its contents. Although classically a disease of elderly population stroke occurs in younger age group also. Stroke in young is infrequent in the west. On the contrary, Indian data gives a higher incidence of 18 to 30 percent. This study aims to evaluate the clinical profile and etiological factors leading to stroke in thirty patients in the age group 15 to 45 years admitted to Medical College, Calicut during May 2000 to April 2001. A detailed history and examination findings were recorded. All patients were subjected to CT brain. The data were collected as per Performa and analyzed. Incidence of stroke in young was 18.5 percent of total stroke patients and incidence of CVA patients admitted was 1.25 percent of the total medical admissions; both were in range as in most of Indian studies. Males and females were in the ratio 2:1 which was similar to majority of Indian studies. 80% cases were thrombotic stroke, rest 20% hemorrhagic and cortical venous thrombosis. Etiological factors were detected in 43.4 percent of cases. Rheumatic heart disease with atrial fibrillation was the major etiological cause for embolic stroke. Incidence of stroke related to pregnancy was less compared to other Indian studies. Risk Factors were detected in 63.3 percent patients which was significant in contributing to the etiology of stroke in young. Smoking and diabetes mellitus formed the most important risk factors in the study followed by untreated hypertension and dyslipidemia.

show abstract

High ethanol consumption as risk factor for intracerebral hemorrhage in young and middle-aged people.

Cited by 85 publications

References 22 publications

Genetic and Environmental Risk Factors for Intracerebral Hemorrhage

Genetic and Environmental Risk Factors for Intracerebral Hemorrhage

Alcohol Consumption and Mortality From Stroke and Coronary Heart Disease Among Japanese Men and Women

A Cl Inical Study of Stroke in Young in a Teaching Hospital

Contact Info

Product

Resources

About