High expression levels of fascin-1 protein in human gliomas and its clinical relevance

Zhang, Hao; Qing-xue, Cong; Shan-guo, Zhang; Zhai, Xiuwei; Li, Huifeng; Li, Shuangqi

doi:10.1515/med-2018-0080

Cited by 9 publications

(7 citation statements)

References 23 publications

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“…On the other hand, 2D magnets such as Fe 3 GeTe 2 , CrGeTe 3 , and CrI 3 , have recently sparked enormous attention, due to their unique magnetism in the 2D limit and expressed potential for application in spintronic devices. However, most of these magnetic materials in the 2D limit are unstable in air, which makes further investigations into their intrinsic magnetism and practical applications difficult.…”

Section: Summary and Future Outlookmentioning

confidence: 99%

Recent Progress in CVD Growth of 2D Transition Metal Dichalcogenides and Related Heterostructures

et al. 2019

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www.advmat.de www.advancedsciencenews.com production challenging. Since the discovery of the chemical vapor deposition (CVD) method as a successful approach for the growth of graphene crystals, [53,54] the method has also been expanded to the preparation of other 2D layered materials. Currently, this approach has been extended to rationally design various 2D TMD materials, such as MoS 2 nanosheets, [55][56][57][58] MoSe 2 nanosheets, [59,60] WS 2 nanosheets, [61,62] ReS 2 nanosheets, [63] and some heterostructures, [64,65] which have sparkled several interesting chemical and electronic properties. Although various 2D TMDs have been successfully grown using a facile CVD method, the intrinsic growth mechanism and the batch production of wafer-scale films, conducive to the high-performance in electronics/optoelectronics and other fields, still need more exploration. Very recently, some important progress on the synthesis of 2D TMDs, multi-heterostructures and superlattices has been realized.Herein, we concentrate on the recent progress in the synthesis of 2D TMDs and related heterostructures via the CVD method. We start with the effects of some key factors such as temperature, carrier gas, and the ratio of precursors on the synthesis of 2D TMDs via CVD technique. Then we summarize the importance of the growth substrates and the growth system to large-scale synthesis. Hence, large-scale 2D TMDs have been obtained on the basis of properly designed CVD growth. Furthermore, some recent breakthroughs in the growth of new kinds of semiconducting and metallic 2D TMDs via the CVD technique are described. The fundamental electronic properties and unique physical phenomena emanating from high quality CVD-grown TMDs are also reviewed. Finally, the controlled growth of alloys with tunable band structures, different multiheterostructures with atomically sharp interfaces and superlattices from 2D TMD crystals is analyzed, which can offer further step for the synthesis of 2D crystals and provides significantly more material systems. Lastly, we emphasize a summary of this review and the future prospects of these materials.Recently, the CVD method has been widely regarded as a technique available for growing 2D atomic crystals. Various atomically thin layered MX 2 semiconductors, such as MoS 2 , [55,66,67] WS 2 , [68] MoSe 2 , [69] MoTe 2 , [70,71] etc., have been successfully achieved by the CVD method. Through in-depth research on the growth dynamics in the CVD system, several key factors in the growth process for obtaining a large-scale, uniform monolayer MX 2 have been explored. For example, triangular WS 2 flakes were synthesized on a sapphire substrate via a CVD system, and a detailed analysis of the controllable growth behavior was given. [61] The growth system is maintained at a very low pressure during the growth process via an operating pump, which provides a uniform flow of vapor precursors and is beneficial to the uniform growth. First, the distance between the source and substrate (D ss ) was discovered to be a vital fa...

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Section: Summary and Future Outlookmentioning

confidence: 99%

Recent Progress in CVD Growth of 2D Transition Metal Dichalcogenides and Related Heterostructures

et al. 2019

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“…Moreover, CrX 3 (X = I, Br, Cl) is usually synthesized with multilayers stacked together by vdW interactions. 6,9,14,[22][23][24][25][26][27][28]30,31,35,53,73,74 So the stacking-induced modifications of the properties need to be systemically discussed. Taking BL MoSSe as a reference, 11 six different stacking patterns (AA-II, AA-ClI, AA-ClCl, AB-ClI, AB-II and AB-ClCl) of BL Cr 2 Cl 3 I 3 are considered, and the optimized geometries are shown in Fig.…”

Section: Effect Of the Stacking Ordersmentioning

confidence: 99%

“…As a possible modulating parameter, magnetism sets up a new routine of developing 2D devices for electronic and spintronic applications. [21][22][23][24] Magnetic fields 14,25 and electric fields 23,[26][27][28] are found to be able to tune the magnetism and tunneling resistance in few-layer CrI 3 23,25-27,29-33 and Cr 2 Ge 2 Te 6 . 14,34 The high magnetic transition temperatures, 14,24,35 various spin configurations, 23,26,27,30,32,36 different electronic properties, 19,37 and higher magnetic anisotropy energy [38][39][40] of semiconducting magnetic materials are the center of the attention in the development of 2D magnetic devices.…”

Section: Introductionmentioning

confidence: 98%

“…11,44,45 The successful synthesis and novel properties of 2D Janus materials could allow them to work as sensors, 44 field-effect transistors, and ultra-sensitive detectors. 46 On the other hand, the successful experimental realization of 2D magnets [21][22][23]27,28,30,35,47 may provide an exciting new platform for the application of low-dimensional spintronics. CrI 3 composed of three atomic layers like a sandwich provides the possibility of forming a Janus structure with intrinsic magnetism.…”

Section: Introductionmentioning

confidence: 99%

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Tunable electronic and magnetic properties of monolayer and bilayer Janus Cr₂Cl₃I₃: a first-principles study

Guan

Luo

et al. 2020

Mater. Adv.

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“…Recently, the study by Zhang et al showed that fascin expression in glioma tissue was higher than that of normal brain tissue and that high fascin expression correlated with World Health Organization (WHO) grading of glioma patients. Moreover a multivariate analysis showed that high expression of fascin protein was an independent predictor of the prognosis of patients with glioma [110]. Intriguingly, Wang et al showed that the TCA with anti-fascin activity, imipramine, significantly retarded the proliferation of primary and immortalized glioma cells by inhibiting YAP protein, a recognized oncogene in glioma [56].…”

Section: Cancer Of Central Nervous Systemmentioning

confidence: 99%

Antitumoral Effects of Tricyclic Antidepressants: Beyond Neuropathic Pain Treatment

Asensi-Cantó

López-Abellán

Castillo-Guardiola

et al. 2022

Cancers

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Growing evidence shows that nerves play an active role in cancer development and progression by altering crucial molecular pathways and cell functions. Conversely, the use of neurotropic drugs, such as tricyclic antidepressants (TCAs), may modulate these molecular signals with a therapeutic purpose based on a direct antitumoral effect and beyond the TCA use to treat neuropathic pain in oncology patients. In this review, we discuss the TCAs’ safety and their central effects against neuropathic pain in cancer, and the antitumoral effects of TCAs in in vitro and preclinical studies, as well as in the clinical setting. The current evidence points out that TCAs are safe and beneficial to treat neuropathic pain associated with cancer and chemotherapy, and they block different molecular pathways used by cancer cells from different locations for tumor growth and promotion. Likewise, ongoing clinical trials evaluating the antineoplastic effects of TCAs are discussed. TCAs are very biologically active compounds, and their repurposing as antitumoral drugs is a promising and straightforward approach to treat specific cancer subtypes and to further define their molecular targets, as well as an interesting starting point to design analogues with increased antitumoral activity.

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High expression levels of fascin-1 protein in human gliomas and its clinical relevance

Cited by 9 publications

References 23 publications

Recent Progress in CVD Growth of 2D Transition Metal Dichalcogenides and Related Heterostructures

Recent Progress in CVD Growth of 2D Transition Metal Dichalcogenides and Related Heterostructures

Tunable electronic and magnetic properties of monolayer and bilayer Janus Cr₂Cl₃I₃: a first-principles study

Antitumoral Effects of Tricyclic Antidepressants: Beyond Neuropathic Pain Treatment

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High expression levels of fascin-1 protein in human gliomas and its clinical relevance

Cited by 9 publications

References 23 publications

Recent Progress in CVD Growth of 2D Transition Metal Dichalcogenides and Related Heterostructures

Recent Progress in CVD Growth of 2D Transition Metal Dichalcogenides and Related Heterostructures

Tunable electronic and magnetic properties of monolayer and bilayer Janus Cr2Cl3I3: a first-principles study

Antitumoral Effects of Tricyclic Antidepressants: Beyond Neuropathic Pain Treatment

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Tunable electronic and magnetic properties of monolayer and bilayer Janus Cr₂Cl₃I₃: a first-principles study