High Expression of ABL2 Suppresses Apoptosis in Gastric Cancer

Liu, Yun; Shao, Chen; Zhu, Linqi; Jiang, Sihong; Li, Guanlin; Zhang, Wei; Lin, Yangming; Ni, Ying; Cao, Hui; Shao, Shihe

doi:10.1007/s10620-018-5111-7

Cited by 13 publications

(6 citation statements)

References 15 publications

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“…As a member of the Abelson family, ABL2 has been confirmed to exert a carcinogenic effect in different kinds of cancers. For example, high expression of ABL2 is identified in gastric cancer cells and suppresses cell apoptosis in gastric cancer [ 45 ]. Besides, up-regulation of ABL2 is reported to predict poor prognosis of hepatocellular carcinomas and accelerate cell migration and invasion [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Long noncoding RNA LINC00858 aggravates the progression of esophageal squamous cell carcinoma via regulating the miR-425-5p/ABL2 axis

Li,

Ding,

Han

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

Long noncoding RNA LINC00858 aggravates the progression of esophageal squamous cell carcinoma via regulating the miR-425-5p/ABL2 axis

Li,

Ding,

Han

et al. 2024

Heliyon

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“…ABL2 belongs to Abelson family of non-receptor tyrosine kinase and regulates numerous cellular functions, such as cell viability, migration, apoptosis, and morphogenesis, in response to stimulation of cell surface receptors [ 31 , 32 ]. Liu et al demonstrated that ABL2 inhibited the cell apoptosis of gastric cancer [ 33 ]. Xing et al reported that the upregulation of ABL2 contributed to unsatisfactory prognosis and facilitated cell migration and invasion in HCC [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

CircSLC7A6 promotes the progression of Wilms’ tumor via microRNA-107/ ABL proto-oncogene 2 axis

Hao

Gao

et al. 2022

Bioengineered

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The dysregulation of circular RNAs (circRNAs) has been proved to be involved in the carcinogenesis of various cancers. Nevertheless, the biological function of circSLC7A6 remains unclear in Wilms’ tumor (WT). In our study, we found that circSLC7A6 was upregulated in cancerous WT tissues and cells. Cell apoptosis was increased while cell viability, migration, and invasion were repressed by circSLC7A6 silencing. Besides, circSLC7A6 knockdown suppressed WT tumor growth in vivo . miR-107 was identified as a direct target of circSLC7A6, and circSLC7A6 could negatively regulate miR-107 expression. In addition, circSLC7A6 knockdown inhibited WT progression, while the effect was partially abolished by the downregulation of miR-107. Additionally, ABL proto-oncogene 2 axis (ABL2) was verified as a downstream gene of miR-107, and circSLC7A6 could upregulate ABL2 expression by serving as a ceRNA of miR-107. Moreover, functional assays revealed that ABL2 overexpression reversed the impact of circSLC7A6 depletion on cell proliferation, migration, invasion, and apoptosis of WT. In conclusion, the present study demonstrated that circSLC7A6 facilitated WT progression by upregulating ABL2 through inhibiting miR-107 expression. These results suggested that circSLC7A6 might serve as a potential therapeutic target for WT.

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“…Especially, HSPA6, G0S2, TNFAIP3, GEM, GADD45G, RND1, SERPINB2, and IL24 have come forward with their repressive roles in malignant features of some cancers [ 29 – 35 ]. However, some genes like ABL2, EFNA1, CCL20, CXCL3, BCL2A1, IL20, and IL8, support cancer progression and they have already been highlighted as indicators of poor prognosis or suggested as potential therapeutic targets [ 36 – 40 ]. This finding suggests that upregulated anti-cancerous genes override the effects of upregulated cancerous genes when considering MAL-II previously demonstrated effects [ 7 ] on ATCCs.…”

Section: Discussionmentioning

confidence: 99%

RNA-Seq transcriptome analysis reveals Maackia amurensis leukoagglutinin has antitumor activity in human anaplastic thyroid cancer cells

Bektas

Kaptan

2022

Mol Biol Rep

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Background Lectins are carbohydrate-binding molecules that can bind specifically to the sugar residues of glycoconjugates and are found in almost all organisms. Plant lectins subjected to many studies reported exhibiting anti-cancer activity. This study aimed to investigate the possible molecular mechanisms of Maackia amurensis leukoagglutinin II (MAL-II) treated ATCCs. Methods and results We tested the effects of MAL-II, which is isolated from Amur seeds, on cancerous features of 8505C human anaplastic thyroid cancer cells (ATCCs) on a large scale using RNA-Seq. Transcriptome analysis was performed using Illumina next-generation sequencing technology by using cDNA libraries obtained from total RNA isolates of ATCCs treated with 0.25 µM MAL-II for 24 h. Gene ontology and pathway enrichment analysis were performed for the systematic analysis of gene functions. Moreover, we validated RNA-Seq findings using qPCR. Our results showed that many cancer-related genes such as TENM4, STIM2, SYT12, PIEZO2, ABCG1, SPNS2, ARRB1, and IRX5 were downregulated and many anticancer genes such as HSPA6, G0S2, TNFAIP3, GEM, GADD45G, RND1, SERPINB2, and IL24 were upregulated. Also, pathway enrichment analysis showed that differentially expressed genes were found to be associated with Ras, p53, and apoptosis signaling pathways, which are some important signal transduction pathways in development, proliferation, stem cell control, and carcinogenesis. Conclusion Collectively, our results show that MAL-II treatment reveals significant antitumor activity by changing the expression of many cancer-related genes and implies that MAL-II treatment might be a potential candidate molecule to inhibit the malignancy of human anaplastic thyroid cancer. Supplementary Information The online version contains supplementary material available at 10.1007/s11033-022-07759-6.

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High Expression of ABL2 Suppresses Apoptosis in Gastric Cancer

Abstract: All the data showed that high expression of ABL2 suppresses apoptosis through Ras/Erk and PI3K/AKT signaling pathway in GC cell lines.

Cited by 13 publications

References 15 publications

Long noncoding RNA LINC00858 aggravates the progression of esophageal squamous cell carcinoma via regulating the miR-425-5p/ABL2 axis

Long noncoding RNA LINC00858 aggravates the progression of esophageal squamous cell carcinoma via regulating the miR-425-5p/ABL2 axis

CircSLC7A6 promotes the progression of Wilms’ tumor via microRNA-107/ ABL proto-oncogene 2 axis

RNA-Seq transcriptome analysis reveals Maackia amurensis leukoagglutinin has antitumor activity in human anaplastic thyroid cancer cells

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