2015
DOI: 10.18632/genesandcancer.89
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High expression of cellular retinol binding protein-1 in lung adenocarcinoma is associated with poor prognosis

Abstract: PurposeAdenocarcinoma, the most common non-small cell lung cancer is a leading cause of death worldwide, with a low overall survival (OS) despite increasing attempts to achieve an early diagnosis and accomplish surgical and multimodality treatment strategies. Cellular retinol binding protein-1 (CRBP-1) regulates retinol bioavailability and cell differentiation, but its role in lung cancerogenesis remains uncertain.Experimental designCRBP-1 expression, clinical outcome and other prognostic factors were investig… Show more

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Cited by 19 publications
(23 citation statements)
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“…The present study showed that the methylated PTPRF was focused on the role of regulation of protein binding. In lung adenocarcinomas, CRBP-1 high expression was suggested to be an aggressive phenotype ( 18 ). CPBP-1 is known as a 15 kDa cytosolic binding protein that is crucial in retinol uptake and esterification ( 19 , 20 ).…”
Section: Discussionmentioning
confidence: 99%
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“…The present study showed that the methylated PTPRF was focused on the role of regulation of protein binding. In lung adenocarcinomas, CRBP-1 high expression was suggested to be an aggressive phenotype ( 18 ). CPBP-1 is known as a 15 kDa cytosolic binding protein that is crucial in retinol uptake and esterification ( 19 , 20 ).…”
Section: Discussionmentioning
confidence: 99%
“…CPBP-1 is known as a 15 kDa cytosolic binding protein that is crucial in retinol uptake and esterification ( 19 , 20 ). CPBP-1 was also highly expressed in lung adenocarcinoma ( 18 ), and played an important role in protein binding. Therefore, we consider that the function of methylated PTPRF associated with protein binding is of great importance in lung adenocarcinomas.…”
Section: Discussionmentioning
confidence: 99%
“…Some researches discovered that CRBP-1 was downregulated in hepatocellular carcinoma [ 25 ], endometrial carcinoma [ 19 ], ovarian carcinoma [ 20 ] and breast carcinoma [ 18 ]. On the contrary, CRBP-1 was upregulated in astrocytic gliomas [ 26 ], leiomyosarcoma [ 27 ] and lung adenocarcinoma [ 15 ]. Moreover, decreased expression of CRBP-1 was found relevant to shorter survival time in endometrial carcinoma, ovarian carcinoma and breast carcinoma, while increased expression of CRBP-1 was verified to damage survival time in astrocytic gliomas [ 26 ], leiomyosarcoma [ 27 ] and lung adenocarcinoma [ 15 ].…”
Section: Discussionmentioning
confidence: 99%
“…Among them,CRBP-1 takes an important part in the uptake and subsequent esterification of retinol and improving bioavailability and transcriptional activities. In addition, CRBP-1 plays a vital role in the embryonic development, growth, vision and survival of vertebrates [ 15 , 16 ].…”
Section: Introductionmentioning
confidence: 99%
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