High expression of cyclin A is associated with poor prognosis in endometrial endometrioid adenocarcinoma

Abstract

Cyclins are a group of proteins that act as activators to cyclin-dependent kinases and are required for normal cell cycle transitions. Cyclin A is involved in the transitions between G1 to S and G2 to M. Its deregulation has been linked to a number of neoplasms, including endometrial cancer. The prognostic significance of cyclin A expression seems to be cancer-specific, and current knowledge on its impact on survival of endometrial cancer is limited. This study aimed to investigate the effect of cyclin A expression on cancer-specific survival and its correlation with conventional prognostic factors in endometrioid adenocarcinoma. Biopsies obtained from 211 patients were immunohistochemically stained for cyclin A and differences in expression analyzed at the Oulu University Hospital. Patients were divided into two groups utilizing the ROC curve. Further survival analyses were carried out between these two groups. In this study, we show that cyclin A expression correlates with tumor grade and FIGO stage. We also show that cyclin A is an independent prognostic factor in endometrioid adenocarcinoma. Whether cyclin A plays a role in tumorigenesis or merely is a marker of increased proliferation requires further studies.

Biodegradable zinc oxide composite scaffolds promote osteochondral differentiation of mesenchymal stem cells

“…In osteogenic culture, enhancement of cell growth and early and late markers of osteogenesis was observed on ZnO composite scaffolds with or without inductive factors. Gene expression for Cyclin A2 (CCNA2), which regulates cell cycle through promoting transition between G1 to S and G2 to M phases (Santala et al, ), was high for cells on 2.5%, 5%, and 10% ZnO composite scaffolds. Zinc promotes cell proliferation and DNA synthesis (Beyersmann & Haase, ).…”

“…Although the chondrogenic medium has insulin, sodium tungstate and vanadium, which are also insulin mimetics, were found to enhance chondrogenesis and osteogenesis, respectively, synergistically with insulin (Khader et al, 2016;Schussler et al, 2017). transition between G1 to S and G2 to M phases (Santala et al, 2014), was high for cells on 2.5%, 5%, and 10% ZnO composite scaffolds.…”

Dietary myo-inositol modulates immunity through antioxidant activity and the Nrf2 and E2F4/cyclin signalling factors in the head kidney and spleen following infection of juvenile fish with Aeromonas hydrophila

“…Cyclins, such as cyclin D1, cyclin A and cyclin E, play an important role in cell proliferation in the distal nephron tubule of zebrafish [27], human endometrial endometrioid adenocarcinoma [28], and zebrafish embryogenesis [29], respectively. Cyclin D1 expression also plays a role in DNA damage repair in humans [30], and the signalling E2F transcription factor 4 (E2F4) has been reported to contribute to increased pituitary cell proliferation in zebrafish [31] and to potentially regulate DNA repair in humans [32].…”

Cyclins A, B, E and p27 in Endometrial Endometrioid Adenocarcinoma

“…p27 positivity was evaluated as the percentage of positive nuclear staining/whole tumor area in the section. Other staining patterns were evaluated separately (8)(9)(10).…”

“…Previously, we have analyzed the impact of cyclin A, cyclin B and cyclin E on endometrial endometrioid adenocarcinoma (8)(9). In this study, we evaluate the effects of p27 expression on conventional clinicopathological and prognostic factors in the same patient population and further analyze the correlations between cyclins A, B and E, as well as p27, and their relation to prognosis.…”