High expression of estrogen-related receptor α is significantly associated with poor prognosis in patients with colorectal cancer

Liang, Rong; Lin, Yan; Yuan, Chunling; Liu, Zhi‐Hui; Li, Yongqiang; Luo, Xi; Ye, Jiazhou; Ye, Haihong

doi:10.3892/ol.2018.8011

Cited by 20 publications

(30 citation statements)

References 31 publications

(40 reference statements)

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“…Colorectal cancer (CRC) is one of the most common malignancy types and the fourth most common cause of tumor associated mortality globally in 2008 (1). Despite improvements in the diagnosis and treatment of CRC, the efficacy of surgery and chemotherapy remains unsatisfactory, and the 5 year survival rate of patients with CRC with metastasis remains <10% in 2012 globally (2-4).…”

Section: Introductionmentioning

confidence: 99%

Immunoglobulin‑like transcript 4 and human leukocyte antigen‑G interaction promotes the progression of human colorectal cancer

et al. 2019

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Immunoglobulin like transcript (ILT) 4, a negative regulator of immune response in allograft rejection, autoimmunity and infectious diseases, has recently been determined to serve important roles in tumor development. In the present study, the co expression of ILT4 and human leukocyte antigen G (HLA-G) in tissues of human primary colorectal cancer (CRC) was revealed, and its association with older age, advanced stage, regional lymph node involvement and poor overall survival time was identified. In CRC cell lines, ILT4 and HLA-G co expression and their autocrine regulation was demonstrated. ILT4 interference affected HLA-G expression and regulated the cell proliferation, invasion and migration of CRC. HLA-G fusion protein treatment also increased ILT4 expression in a dose dependent manner, thereby activating protein kinase B (AKT) and extracellular signal regulated kinase (ERK) signaling, and facilitating the proliferation, migration and invasion of CRC cells. Additionally, the AKT and ERK activation, and CRC cell malignant characteristics induced by HLA-G may be suppressed by blocking ILT4. The present results indicated that the interaction of ILT4 and its ligand HLA-G promotes CRC progression through AKT and ERK signal activation, providing a novel strategy of blocking ILT4/HLA-G for the treatment of CRC.

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Section: Introductionmentioning

confidence: 99%

Immunoglobulin‑like transcript 4 and human leukocyte antigen‑G interaction promotes the progression of human colorectal cancer

et al. 2019

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“…Testicular cancer was significantly increased in both construction and plastic industry workers [ 19 ]. All these cancer types are associated with disturbances of estrogen/testosterone ratio or of their receptors [ 20 , 21 , 22 , 23 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Potential Health Risk of Endocrine Disruptors in Construction Sector and Plastics Industry: A New Paradigm in Occupational Health

Fučić

Galea

Duca

et al. 2018

IJERPH

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Endocrine disruptors (EDs) belong to large and diverse groups of agents that may cause multiple biological effects associated with, for example, hormone imbalance and infertility, chronic diseases such as diabetes, genome damage and cancer. The health risks related with the exposure to EDs are typically underestimated, less well characterized, and not regulated to the same extent as, for example, carcinogens. The increased production and utilization of identified or suspected EDs in many different technological processes raises new challenges with respect to occupational exposure settings and associated health risks. Due to the specific profile of health risk, occupational exposure to EDs demands a new paradigm in health risk assessment, redefinition of exposure assessment, new effects biomarkers for occupational health surveillance and definition of limit values. The construction and plastics industries are among the strongest economic sectors, employing millions of workers globally. They also use large quantities of chemicals that are known or suspected EDs. Focusing on these two industries, this short communication discusses: (a) why occupational exposure to EDs needs a more specific approach to occupational health risk assessments, (b) identifies the current knowledge gaps, and (c) identifies and gives a rationale for a future occupational health paradigm, which will include ED biomarkers as a relevant parameter in occupational health risk assessment, surveillance and exposure prevention.

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“…Studies have found that ERRα-induced metabolic reprogramming can promote the survival of lapatinib-resistant cancer cells and demonstrates the potential of ERRα inhibition as adjunctive therapy for poor prognosis of HER2-positive breast cancer 26. High expression of ERRα was also found associating with poor prognosis in breast cancer,28 prostate cancer,29 colon cancer,30 ovarian cancer,31,32 endometrial cancer, and cervical cancer,33 while its association with LUAD has not yet been profiled. In this study, the positive expression of ERRα in lung cancer tissues was significantly higher than in paracancerous tissues.…”

Section: Discussionmentioning

confidence: 99%

<p>ERRα is an aggressive factor in lung adenocarcinoma indicating poor prognostic outcomes</p>

Li¹,

Wang²,

Wu³

et al. 2019

CMAR

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Purpose Lung cancer is one of the most life-threatening cancer worldwide with poor prognosis attributed to the lack of early diagnosis and proper therapy. The estrogen-related receptor alpha (ERRα) is a multifunctional protein not limited to bind ligands and has been reported to be associated with numerous cancers. This study aimed to investigate the potential role of ERRα in lung cancer and to provide a novel perspective for lung cancer early diagnosis, targeted therapy, and prognosis assessment. Methods The correlation between ERRα mRNA expression and survival time of the online clinical data about lung cancer was analyzed by using Kaplan–Meier (KM) plotter. A mouse model of lung adenocarcinoma (LUAD) was constructed to detect the expression level of ERRα in tumor tissues. ERRα-knockdown LUAD cells were generated and the impacts of ERRα on cell proliferation, invasion, and metastasis were further analyzed. Cancerous and paracancerous tissues were collected to semi-quantitative the levels of ERRα in LUAD clinical samples (n=88), combined with clinical information for prognostic analysis. Results The KM plotter analysis suggested that ERRα is correlated with poor prognosis in LUAD (n=720) rather than in lung squamous cell carcinoma (LSCC) (n=524). ERRα is also upregulated in tumor tissues obtained from LUAD model mice. Quantitative analysis suggested an abnormal elevation of ERRα in LUAD cells rather than in LSCC cells. The results demonstrated that downregulation of ERRα impairs proliferation, invasion and migration abilities ( P <0.01). The prognostic analysis showed that the overexpressed ERRα in LUAD was positively correlated with low survival rates (HR=1.597). The results indicate that the death risk of ERRα high expression is 1.597 times higher than ERRα low level in LUAD patients. Conclusion In summary, our findings suggest that ERRα is a potential aggressive factor of LUAD which implies poor prognosis.

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High expression of estrogen-related receptor α is significantly associated with poor prognosis in patients with colorectal cancer

Cited by 20 publications

References 31 publications

Immunoglobulin‑like transcript 4 and human leukocyte antigen‑G interaction promotes the progression of human colorectal cancer

Immunoglobulin‑like transcript 4 and human leukocyte antigen‑G interaction promotes the progression of human colorectal cancer

Potential Health Risk of Endocrine Disruptors in Construction Sector and Plastics Industry: A New Paradigm in Occupational Health

<p>ERRα is an aggressive factor in lung adenocarcinoma indicating poor prognostic outcomes</p>

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