High expression of ghrelin and obestatin prepropeptide in tumor tissues predicted adverse overall survival in gastric carcinoma patients

Wu, Xiandan; Wu, Yongning; Ye, Binhua; Wu, Fubin; Wang, Peien

doi:10.1097/md.0000000000020635

Cited by 9 publications

(9 citation statements)

References 21 publications

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“…There were several literatures using the same dataset in this study ( Chen et al, 2020 ; Chi et al, 2020 ; Li Z. et al, 2020 ; Tian et al, 2020 ; Wang F. et al, 2020 ; Wu et al, 2020 ). However, most of them selected multiple genes for GC by some routine methods and did not concentrate on one gene/biomarker.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Cyclin-Dependent Kinase 1 as an Independent Prognostic Factor for Gastric Cancer Based on Statistical Methods

Zhang

Zou

et al. 2020

Front. Cell Dev. Biol.

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ObjectiveThe aim of this study was to investigate the expression of cyclin-dependent kinase 1 (CDK1) in gastric cancer (GC), evaluate its relationship with the clinicopathological features and prognosis of GC, and analyze the advantage of CDK1 as a potential independent prognostic factor for GC.MethodsThe Cancer Genome Atlas (TCGA) data and corresponding clinical features of GC were collected. First, the aim gene was selected by combining five topological analysis methods, where the gene expression in paracancerous and GC tissues was analyzed by Limma package and Wilcox test. Second, the correlation between gene expression and clinical features was analyzed by logistic regression. Finally, the survival analysis was carried out by using the Kaplan–Meier. The gene prognostic value was evaluated by univariate and multivariate Cox analyses, and the gene potential biological function was explored by gene set enrichment analysis (GSEA).ResultsCDK1 was selected as one of the most important genes associated with GC. The expression level of CDK1 in GC tissues was significantly higher than that in paracancerous tissues, which was significantly correlated with pathological stage and grade. The survival rate of the CDK1 high expression group was significantly lower than that of the low expression group. CDK1 expression was significantly correlated with overall survival (OS). CDK1 expression was mainly involved in prostate cancer, small cell lung cancer, and GC and was enriched in the WNT signaling pathway and T cell receptor signaling pathway.ConclusionCDK1 may serve as an independent prognostic factor for GC. It is also expected to be a new target for molecular targeted therapy of GC.

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Section: Discussionmentioning

confidence: 99%

Analysis of Cyclin-Dependent Kinase 1 as an Independent Prognostic Factor for Gastric Cancer Based on Statistical Methods

Zhang

Zou

et al. 2020

Front. Cell Dev. Biol.

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“…Ghrelin alone may not be a useful biomarker in evaluating the risk of gastric malignancies, but when coupled with other early detection biomarkers, such as pepsinogen I and pepsinogen I/II ratio, as part of a complex panel it may provide higher accuracy ( 118 ). Recent advances in the field point towards the potential role of the ghrelin gene, growth hormone secretagogue receptor ligand (GHRL), as a poor prognosis biomarker in GC ( 136 ). A study involving 295 patients with GC and data from 4 gene expression microarrays, found 12 upregulated and 59 downregulated differentially expressed genes, with high expression of GHRL associated with poor overall survival of patients with GC ( 136 ).…”

Section: Ghrelin and Gi Tract Tumorsmentioning

confidence: 99%

“…Recent advances in the field point towards the potential role of the ghrelin gene, growth hormone secretagogue receptor ligand (GHRL), as a poor prognosis biomarker in GC ( 136 ). A study involving 295 patients with GC and data from 4 gene expression microarrays, found 12 upregulated and 59 downregulated differentially expressed genes, with high expression of GHRL associated with poor overall survival of patients with GC ( 136 ).…”

Section: Ghrelin and Gi Tract Tumorsmentioning

confidence: 99%

Ghrelin and its role in gastrointestinal tract tumors (Review)

et al. 2021

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Ghrelin, an orexigenic hormone, is a peptide that binds to the growth hormone secretagogue receptor; it is secreted mainly by enteroendocrine cells in the oxyntic glands of the stomach. Ghrelin serves a role in both local and systemic physiological processes, and is implicated in various pathologies, including neoplasia, with tissue expression in several types of malignancies in both in vitro and in vivo studies. However, the precise implications of the ghrelin axis in metastasis, invasion and cancer progression regulation has yet to be established. In the case of gastrointestinal (GI) tract malignancies, ghrelin has shown potential to become a prognostic factor or even a therapeutic target, although data in the literature are inconsistent and unsystematic, with reports untailored to a specific histological subtype of cancer or a particular localization. The evaluation of immunohistochemical expression shows a limited outlook owing to the low number of cases analyzed, and in vivo analyses have conflicting data regarding differences in ghrelin serum levels in patients with cancer. The aim of this review was to examine the relationship between ghrelin and GI tract malignancies to demonstrate the inconsistencies in current results and to highlight its clinical significance in the outcome of these patients.

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“…In addition, Wu etc. analyzed the DNA chip expression data of GEO database GSE26942, GSE33335, GSE63089 and GSE79973 and found that MT1G is low-expressed in gastric cancer ( Wu et al ., 2020 ). However, there are few reports about the role of MT1G in gastric cancer, and its mechanism is unclear.…”

Section: Introductionmentioning

confidence: 99%

MT1G inhibits the growth and epithelial-mesenchymal transition of gastric cancer cells by regulating the PI3K/AKT signaling pathway

Fan

Zhao

et al. 2022

Genet. Mol. Biol.

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Gastric carcinoma (GC) is a malignant tumor that has high mortality and morbidity worldwide. Although many efforts have been focused on the development and progression of GC, the underlying functional regulatory mechanism of GC needs more clarification. Metallothionein 1G (MT1G) is a member of the metallothionein family (MTs), and hypermethylation of MT1G occurred in a variety of cancers, including gastric cancer. However, the functional mechanism of MT1G in GC remains unclear. Here, we demonstrated that MT1G was down-regulated in GC tissues and cells. Overexpression of MT1G inhibited cell proliferation, foci formation and cell invasion, while knockdown of MT1G increased cell proliferation, foci formation and cell invasion. In addition, MT1G overexpression inhibited cell cycle progression and MT1G deficiency exerted opposite phenotype. p-AKT was negatively regulated by MT1G. In summary, our study reveals that MT1G exerts crucial role in regulating of cell proliferation and migration of gastric cancer, providing new insights for MT1G-related pathogenesis and a basis for developing new strategies for treatment of GC.

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High expression of ghrelin and obestatin prepropeptide in tumor tissues predicted adverse overall survival in gastric carcinoma patients

Cited by 9 publications

References 21 publications

Analysis of Cyclin-Dependent Kinase 1 as an Independent Prognostic Factor for Gastric Cancer Based on Statistical Methods

Analysis of Cyclin-Dependent Kinase 1 as an Independent Prognostic Factor for Gastric Cancer Based on Statistical Methods

Ghrelin and its role in gastrointestinal tract tumors (Review)

MT1G inhibits the growth and epithelial-mesenchymal transition of gastric cancer cells by regulating the PI3K/AKT signaling pathway

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