2017
DOI: 10.3892/ol.2017.6697
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High expression of GP73 in primary hepatocellular carcinoma and its function in the assessment of transcatheter arterial chemoembolization

Abstract: Abstract. Golgi glycoprotein 73 (GP73) is a type II Golgi transmembrane protein and a potential novel marker for the diagnosis of primary hepatocellular carcinoma (PHC). However, its reliability as a serum marker for the diagnosis of PHC following transcatheter arterial chemoembolization (TACE) remains unknown. The aim of the present study was to evaluate the diagnostic value of serum GP73 levels in patients with PHC, to determine its diagnostic accuracy in patients with PHC following TACE. Reverse transcripti… Show more

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Cited by 17 publications
(13 citation statements)
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“…Researches have revealed that GOLM1 plays a vital role in many cancers, including hepatocellular carcinoma, prostate cancer and CC. 35 – 37 GOLM1 silencing inhibits the migration and invasion of U251 cells and U87 cells in glioma. 38 GOLM1 siRNA reverses the promoting effect of miR-143 inhibitor on cell migration of CC.…”
Section: Discussionmentioning
confidence: 99%
“…Researches have revealed that GOLM1 plays a vital role in many cancers, including hepatocellular carcinoma, prostate cancer and CC. 35 – 37 GOLM1 silencing inhibits the migration and invasion of U251 cells and U87 cells in glioma. 38 GOLM1 siRNA reverses the promoting effect of miR-143 inhibitor on cell migration of CC.…”
Section: Discussionmentioning
confidence: 99%
“…was associated with tumor size, differentiation, grade and survival, which indicate that GP73 is a valuable marker using as an independent diagnostic tool for hepatocellular carcinoma [14][15][16][17][18]. However, knowledge on the function of GP73 is limited in gastric cancer.…”
Section: Discussionmentioning
confidence: 99%
“…High-expression of GP73 in HCC exhibits correlation with multiple clinical and pathological characters, including tumor size, differentiation, grade and survival. These results suggests that GP73 is a valuable independent diagnostic marker for HCC [14][15][16][17][18]. However, knowledge on the function of GP73 is limited in gastric cancer.…”
Section: Discussionmentioning
confidence: 99%