High expression of KIF3A is a potential new parameter for the diagnosis and prognosis of breast cancer

Abstract

Kinesin Family Member 3A (KIF3A) was recognized as a key factor of ciliogenesis and transport system of primary cilia in normal cells. However, its possible function on cancer cells has yet to be identified. In the present study, microarray tissue chips, including 230 breast cancer samples, were applied to determine the KIF3A expression pattern by immunological histological chemistry. Statistical analysis on the KIF3A expression level and the currently used clinicopathological characteristics of breast cancer patients was carried out. Follow-up data of these patients over 10 years were also used to evaluate the relationship between KIF3A and the survival rate. The expression levels of KIF3A were significantly higher in 140 breast cancer tissues than those of 90 para-carcinoma samples, which served as controls (P<0.001). In addition, in a further 70 paired samples, the same higher expression level was observed in cancer tissues compared with their self-paired controls (P<0.001). Furthermore, the high expression of KIF3A in breast cancer tissue correlated with the status of estrogen receptor, androgen receptor, epidermal growth factor receptor and Ki-67 of breast cancer patients, and were also related to their pathology grade and lymph node metastasis. The survival analysis showed a better survival rate in the patients with a higher expression level of KIF3A. Collectively, the triadic associations of KIF3A, the currently used clinicopathological parameters and survival rate suggest that KIF3A is involved in the tumorigenesis and progression of breast cancer. Thus, KIF3A could be considered a promising novel prognostic index in breast cancer.

<p>KIF4A Promotes Clear Cell Renal Cell Carcinoma (ccRCC) Proliferation in vitro and in vivo</p>

“…Results are presented as mean ± SD, *P < 0.05. participated in the development of breast cancer. 36 These studies, together with our results, indicate the possible roles of KIFs as potential therapeutic targets. Collectively, our results demonstrated that KIF4A was highly expressed in human HCC tissues.…”

Retracted: Kinesin family member 3A stimulates cell proliferation, migration, and invasion of bladder cancer cells in vitro and in vivo

“…KIF3A was abnormally expressed in multiple types of tumor tissues [18,19,20]. Abnormal KIF3A level was thought as a potential bio-marker for the early stage diagnosis and prognosis of breast cancer [18]. KIF3A also fascinated the proliferation and invasion of prostate cancer cells targeting Wnt signaling pathways [19].…”

Weighted Gene Coexpression Network Analysis of Features That Control Cancer Stem Cells Reveals Prognostic Biomarkers in Lung Adenocarcinoma

“…The KIF gene family, which encodes proteins, is involved in many important physiological processes, especially intracellular transport, chromosome separation, mitotic spindle formation and cytokinesis. Some studies have suggested that mutations in the KIF gene family are involved in the formation of many cancers (Sheng et al, 2018;Xia et al, 2018;Xie et al, 2018). There are few studies on KIF18b and LUAD, and only confirmed that LUAD patients with high KIF18b expression have a poor prognosis.…”