High expression of MAP7 predicts adverse prognosis in young patients with cytogenetically normal acute myeloid leukemia

Fu, Lin; Fu, Huaping; Zhou, Lei; Xu, Keman; Pang, Yifan; Hu, Kai; Wang, Jing; Tian, Li; Liu, Yuanyuan; Wang, Jijun; Jing, Hongmei; Huang, Wenrong; Ke, Xiaoyan; Shi, Jianxin

doi:10.1038/srep34546

Cited by 21 publications

(25 citation statements)

References 48 publications

(52 reference statements)

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“…MAPs play a major role in numerous critical cellular and intracellular activities, such as cell division, motility, differentiation and so on ( Bhat and Setaluri, 2007 ). High expression of MAP7 predicts the tumor recurrence and adverse outcomes in colon cancer and is related to a poor prognosis in patients with cytogenetically normal acute myeloid leukemia ( Blum et al, 2008 ; Fu et al, 2016 ). Although the status of AADAC and MAP7D2 and their correlation with prognosis in GC have seldom been reported in the findings from earlier works, they could provide helpful evidence for potential prognostic biomarkers in future studies due to their significance in the nine-gene signature model.…”

Section: Discussionmentioning

confidence: 99%

Identification of Potential Key Genes Associated With the Pathogenesis and Prognosis of Gastric Cancer Based on Integrated Bioinformatics Analysis

et al. 2018

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Background and Objective: Despite striking advances in multimodality management, gastric cancer (GC) remains the third cause of cancer mortality globally and identifying novel diagnostic and prognostic biomarkers is urgently demanded. The study aimed to identify potential key genes associated with the pathogenesis and prognosis of GC.Methods: Differentially expressed genes between GC and normal gastric tissue samples were screened by an integrated analysis of multiple gene expression profile datasets. Key genes related to the pathogenesis and prognosis of GC were identified by employing protein–protein interaction network and Cox proportional hazards model analyses.Results: We identified nine hub genes (TOP2A, COL1A1, COL1A2, NDC80, COL3A1, CDKN3, CEP55, TPX2, and TIMP1) which might be tightly correlated with the pathogenesis of GC. A prognostic gene signature consisted of CST2, AADAC, SERPINE1, COL8A1, SMPD3, ASPN, ITGBL1, MAP7D2, and PLEKHS1 was constructed with a good performance in predicting overall survivals.Conclusion: The findings of this study would provide some directive significance for further investigating the diagnostic and prognostic biomarkers to facilitate the molecular targeting therapy of GC.

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Section: Discussionmentioning

confidence: 99%

Identification of Potential Key Genes Associated With the Pathogenesis and Prognosis of Gastric Cancer Based on Integrated Bioinformatics Analysis

et al. 2018

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“…However, the role of MAP7 in cancers was rarely studied. Studies showed that MAP7 was upregulated in young patients with cytogenetically normal acute myeloid leukemia and predicts poor outcome [13]. The potential function and mechanism of MAP7 in cancer was still unknown.…”

Section: Discussionmentioning

confidence: 99%

MAP7 promotes migration and invasion and progression of human cervical cancer through modulating the autophagy

et al. 2020

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Background: Microtubule-associated proteins 7(MAP7) was reported to be engaged into the function of neuronal function. The function of MAP7 in human cervical cancer (CC) was unknown. We aimed to uncover the function and mechanism of MAP7 on CC. Methods: We applied qRT-PCR, western blot and immunochemistry to detect the expression difference between normal tissue and CC. In vitro, we establish MAP7 stable knocking down and overexpression cell lines and investigated the function and underlying mechanism of MAP7 in CC. Results: Both mRNA and protein of MAP7 were upregulated in CC compared with the normal tissue. MAP7 was correlated with the clinical stage and tumor size and lymph node metastasis. MAP7 promotes the invasion and migration of CC cell lines. We next detected EMT pathway and autophagy associated pathway. MAP7 promotes the EMT through modulating the autophagy. Conclusion: Taken above, our results showed that MAP7 promotes the migration and invasion and EMT through modulating the autophagy.

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“…The data concerning MAPs in cancer are limited. Up to now, only a few MAPs, including Stathmin-1, EB1, CLIP-170/CLIP1, and some structural MAPs, have been associated with cancerogenesis, outcome prognosis, and chemotherapy sensitivity [268][269][270][271].…”

Section: Microtubule-associated Proteins and Cancermentioning

confidence: 99%

Intrinsic and Extrinsic Factors Affecting Microtubule Dynamics in Normal and Cancer Cells

et al. 2020

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Microtubules (MTs), highly dynamic structures composed of α- and β-tubulin heterodimers, are involved in cell movement and intracellular traffic and are essential for cell division. Within the cell, MTs are not uniform as they can be composed of different tubulin isotypes that are post-translationally modified and interact with different microtubule-associated proteins (MAPs). These diverse intrinsic factors influence the dynamics of MTs. Extrinsic factors such as microtubule-targeting agents (MTAs) can also affect MT dynamics. MTAs can be divided into two main categories: microtubule-stabilizing agents (MSAs) and microtubule-destabilizing agents (MDAs). Thus, the MT skeleton is an important target for anticancer therapy. This review discusses factors that determine the microtubule dynamics in normal and cancer cells and describes microtubule–MTA interactions, highlighting the importance of tubulin isoform diversity and post-translational modifications in MTA responses and the consequences of such a phenomenon, including drug resistance development.

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High expression of MAP7 predicts adverse prognosis in young patients with cytogenetically normal acute myeloid leukemia

Cited by 21 publications

References 48 publications

Identification of Potential Key Genes Associated With the Pathogenesis and Prognosis of Gastric Cancer Based on Integrated Bioinformatics Analysis

Identification of Potential Key Genes Associated With the Pathogenesis and Prognosis of Gastric Cancer Based on Integrated Bioinformatics Analysis

MAP7 promotes migration and invasion and progression of human cervical cancer through modulating the autophagy

Intrinsic and Extrinsic Factors Affecting Microtubule Dynamics in Normal and Cancer Cells

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