High expression of maspin is associated with early tumor relapse in breast cancer

Joensuu, Kristiina; Leidenius, Marjut; Andersson, Leif C.; Heikkilä, Päivi

doi:10.1016/j.humpath.2009.02.006

Cited by 26 publications

(27 citation statements)

References 32 publications

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“…Maspin was originally considered to be a tumor suppressor (30) but recent studies have shown this prognostic role to correlate with nuclear or cytoplasmic subcellular localization (14). In our material, 42% of PTs were Maspinpositive.…”

Section: Ccr7mentioning

confidence: 52%

“…On the other hand, Maspin expression characterizes a more aggressive phenotype of BC (12). Cytoplasmic Maspin expression is correlated with poor prognosis, while nuclear expression of Maspin is a more favorable feature (13,14). However, there are only few studies reporting Maspin expression in regional LN metastases.…”

Section: Abstract Aim: Luminal a Breast Cancers (Bc) Represent Low-rmentioning

confidence: 99%

“…In that study, nuclear expression was strongly associated with better prognostics factors such as positivity for hormone receptors. Several studies have shown cytoplasmic Maspin to be associated with more aggressive tumor features such as negativity for hormone receptors, higher Ki-67 index and aneuploidy (13,14) larger tumor size, higher tumor grade and positivity for p53 (12).…”

Section: Ccr7mentioning

confidence: 99%

See 2 more Smart Citations

Different Expression Patterns of CXCR4, CCR7, Maspin and FOXP3 in Luminal Breast Cancers and Their Sentinel Node Metastases

Strien

Joensuu

Heikkilä

et al. 2017

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Section: Ccr7mentioning

confidence: 52%

Section: Abstract Aim: Luminal a Breast Cancers (Bc) Represent Low-rmentioning

confidence: 99%

Section: Ccr7mentioning

confidence: 99%

See 1 more Smart Citation

Different Expression Patterns of CXCR4, CCR7, Maspin and FOXP3 in Luminal Breast Cancers and Their Sentinel Node Metastases

Strien

Joensuu

Heikkilä

et al. 2017

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“…SERPINB5 regulates the invasive activity of tumor cells (35), inhibits angiogenesis (36), primary tumor growth as well as invasion and metastasis (37). However, high expression of maspin is associated with early tumor relapse in breast cancer (38), and SERPINB5 may contribute to gastric carcinogenesis and have a potential role in tumor metastasis in GC (39,40). Our microarray data, real-time PCR and IHC assay demonstrated that the expression of SERPINB5 was up-regulated at the RNA and protein levels in the GC tissues.…”

Section: Discussionmentioning

confidence: 68%

Development of a survival prediction model for gastric cancer using serine proteases and their inhibitors

Lei

Liu

Zhang

et al. 2011

Experimental and Therapeutic Medicine

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Abstract. Proteolytic enzymes play a key role in the metastatic stage of gastric cancer (GC). In this study, we aimed to identify the serine proteases (SPs) and their inhibitors (serpins) as related to GC. The gene expression profiles of 40 cases of GC were initially detected by cDNA microarray. The results of the differentially expressed SPs and their inhibitor genes from the microarrays were confirmed by real-time PCR. The status of the immunohistochemical staining of the confirmed genes in patients with complete data was used to develop a survival prediction model. Finally, the prediction model was tested in different groups of GC patients. As a result, seven genes, SERPINB5, KLK10, KLK11, HPN, SPINK1, SERPINA5 and PRSS8, were considered as GC progression-related genes. A survival prediction model including the immunohistochemical scores of three genes and the tumor node metastasis (TNM) score was developed: Survival time (months) = 88.8607 + 2.6395 SERPINB5 -12.0772 KLK10 + 13.7562 KLK11 -7.0318 TNM. In conclusion, SERPINB5, KLK10, KLK11, HPN, SPINK1, SERPINA5 and PRSS8 were GC progression-related SPs or serpin genes. The model consisting of the expression profiles of three genes extracted from the microarray study accompanied by the TNM score accurately predicts surgeryrelated survival of GC patients.

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“…Overexpression of maspin is considered an independent factor in predicting a favorable prognosis in breast cancer and lung squamous cell cancer (4)(5)(6). However, it has been also reported that the increased nuclear maspin expression predicts a favorable prognosis, whereas the enhanced cytoplasmic expression is associated with early-relapsing and unfavorable prognosis in breast cancer (7). Enhanced expression of maspin is correlated with unfavorable prognosis in pancreatic, ovarian and colorectal cancer (8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

Different maspin functions in the lung adenocarcinoma A549 and SPC-A1 cell lines

Zhou

Qin

Zhou

et al. 2015

International Journal of Molecular Medicine

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Abstract. Mammary serine protease inhibitor (maspin) is a tumor suppressor gene that is silenced in the majority of cancer cells during metastatic progression by transcriptional and epigenetic mechanisms. The function of maspin in non-small cell lung cancer cells (NSCLC) has not been clearly defined. In the present study, the expression of maspin in NSCLC cell lines, in particular, the adenocarcinoma cell lines, was heterogeneous. While the expression levels of maspin in PC-9 and H460 cell lines were intact, the expression of maspin in the A549 and SPC-A1 cells was hardly detected. Ectopic expression of maspin in A549 cells carrying the K-ras gene point mutation significantly inhibited cell migration and invasion abilities, which was associated with downregulated expression of matrix metalloproteinase-2 and integrin β1. Ectopic expression of maspin in SPC-A1 cells harboring the wild-type K-ras gene predominantly affected cell growth via targeting the AKT signaling molecules. Maspin functions differently in lung adenocarcinoma cells, possibly due to the varied molecular characteristics. IntroductionLung cancer is a leading cause of cancer mortality worldwide. Lung cancer is generally divided into non-small cell lung cancer cells (NSCLC) and SCLC, in which the NSCLC constitutes 80-85% of lung cancers. The three major NSCLC subtypes are adenocarcinoma, squamous cell carcinoma and large cell carcinoma. NSCLC, which is characterized by slow tumor cell growth and dissemination, is refractory to chemotherapy and chest radiotherapy. Several driven genes have been identified in NSCLC, such as EGFR, c-MET and the ALK-EML4 fusion gene (1). Treatment for lung cancer is mainly based on tumor stage, tumor pathology and molecular pathology. Understanding thoroughly the molecular mechanism underlying the aberrant cellular events driving lung cancer progressions is crucial for developing novel treatments.Mammary serine protease inhibitor (maspin), also known as Serpin B5, was first identified in 1994 (2). Maspin belongs to the serine protease inhibitor superfamily, and is predominantly localized in the cytoplasm, but is also localized in the nucleus and membrane, and is secreted. The exact roles of maspin in cancer are far more complicated than initially thought due to the conflicting experimental and clinical data that have been reported. In prostate cancer, the expression of maspin is frequently absent (3). Overexpression of maspin is considered an independent factor in predicting a favorable prognosis in breast cancer and lung squamous cell cancer (4-6). However, it has been also reported that the increased nuclear maspin expression predicts a favorable prognosis, whereas the enhanced cytoplasmic expression is associated with early-relapsing and unfavorable prognosis in breast cancer (7). Enhanced expression of maspin is correlated with unfavorable prognosis in pancreatic, ovarian and colorectal cancer (8-10). High maspin expression correlates with an unfavorable outcome in colorectal cancer in stage III and IV, suggesting th...

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High expression of maspin is associated with early tumor relapse in breast cancer

Cited by 26 publications

References 32 publications

Different Expression Patterns of CXCR4, CCR7, Maspin and FOXP3 in Luminal Breast Cancers and Their Sentinel Node Metastases

Different Expression Patterns of CXCR4, CCR7, Maspin and FOXP3 in Luminal Breast Cancers and Their Sentinel Node Metastases

Development of a survival prediction model for gastric cancer using serine proteases and their inhibitors

Different maspin functions in the lung adenocarcinoma A549 and SPC-A1 cell lines

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