High Expression of PKM2 Was Associated with the Poor Prognosis of Acute Leukemia

Huang, Yi; Chen, Lin-mu; Xie, Jinye; Han, Hui; Zhu, Baofang; Wang, Weijia

doi:10.2147/cmar.s331076

Cited by 7 publications

(4 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PKM1 primarily generates energy in brain and muscle tissues under hypoxic conditions, whereas PKM2 is predominantly expressed in cells with unrestricted proliferation potential, and its activation stimulates tumorigenesis and development through the Warburg effect 66 , 67 . High expression of PKM2 has been linked to poor prognosis in acute leukemia and intrahepatic cholangiocarcinoma 68 , 69 .…”

Section: Discussionmentioning

confidence: 99%

A Novel Prognostic Signature of comprising Nine NK Cell signatures Based on Both Bulk RNA Sequencing and Single-Cell RNA Sequencing for Hepatocellular Carcinoma

Qian¹,

Shi²,

Wang³

et al. 2023

J. Cancer

View full text Add to dashboard Cite

Background: Hepatocellular carcinoma (HCC) has limited prognostic prediction due to its heterogeneity. Understanding the role of natural killer (NK) cells in HCC is vital for prognosis and immunotherapy guidance. We aimed to identify NK cell marker genes through scRNA-seq and develop a prognostic signature for HCC. Methods: We analyzed scRNA-seq data (GSE149614) from 10 patients and bulk RNA-seq data from 786 patients with clinicopathological information. NK cell marker genes were identified using clustering and marker finding functions. A predictive risk signature was constructed using LASSO-COX algorithm. Functional annotations and immune cell infiltration analysis were performed, and the nomogram's performance was evaluated. Results: We identified 79 NK cell marker genes associated with NK cell-mediated cytotoxicity, apoptosis, and immune response. The multigene signature significantly correlated with overall survival (OS) in TCGA-LIHC cohort and was validated in other cohorts. Low-risk patients exhibited higher immune cell infiltration, including CD8 + T cells. The risk signature was an independent prognostic factor for OS (HR > 1, p < 0.001). The nomogram combining the risk signature and clinical predictors demonstrated robust prognostic ability. Conclusion:We developed a nine-gene signature prognostic model based on NK cell marker genes to accurately assess the prognostic risk of HCC. This model can be a valuable tool for personalized evaluation post-surgery. Our study underscores the potential of NK cells in HCC prognosis and highlights the importance of scRNA-seq analysis in identifying prognostic markers.

show abstract

Section: Discussionmentioning

confidence: 99%

A Novel Prognostic Signature of comprising Nine NK Cell signatures Based on Both Bulk RNA Sequencing and Single-Cell RNA Sequencing for Hepatocellular Carcinoma

Qian¹,

Shi²,

Wang³

et al. 2023

J. Cancer

View full text Add to dashboard Cite

show abstract

“…PKM2 exists as a low-activity catalytic dimer or highly active tetramer [ 48 ], and a balance of these two forms has been shown to be important for tumorigenesis [ 47 ]. PKM2 has been identified to play a significant role in leukemogenesis [ 49 , 50 ]. In leukemia cells, SUMOylation of PKM2 results in the destabilization of PKM2 tetramer [ 51 ].…”

Section: Metabolic Reprogramming In Cancer At the Rate-limiting Steps...mentioning

confidence: 99%

The Role of Reprogrammed Glucose Metabolism in Cancer

Ediriweera

Jayasena

2023

Metabolites

View full text Add to dashboard Cite

Cancer cells reprogram their metabolism to meet biosynthetic needs and to adapt to various microenvironments. Accelerated glycolysis offers proliferative benefits for malignant cells by generating glycolytic products that move into branched pathways to synthesize proteins, fatty acids, nucleotides, and lipids. Notably, reprogrammed glucose metabolism and its associated events support the hallmark features of cancer such as sustained cell proliferation, hijacked apoptosis, invasion, metastasis, and angiogenesis. Overproduced enzymes involved in the committed steps of glycolysis (hexokinase, phosphofructokinase-1, and pyruvate kinase) are promising pharmacological targets for cancer therapeutics. In this review, we summarize the role of reprogrammed glucose metabolism in cancer cells and how it can be manipulated for anti-cancer strategies.

show abstract

“…As a prognostic and diagnostic marker of malignant neoplasms, PKM2 plays a critical role in maintaining the metabolic program of neoplastic cells in non-muscle-invasive and highly differentiated muscle-invasive bladder carcinomas [499], colorectal cancer [500], ovarian carcinoma [501], etc. In addition to its involvement in the development of solid tumors, in an evaluation of the blood plasma of patients with acute myeloid leukemia, acute lymphoblastic leukemia (ALL) showed significantly higher levels of PKM 2, the values of which were negatively correlated with the prognosis of survival [502]. Moreover, Wang et al found that the oncogenic functions of PKM2 are implemented not only because of the ability of the enzyme to enhance glycolysis but also to mediate the activation of autophagy by increasing the phosphorylation of the key protein of the early process-initiation Beclin-1 [503], contributing to cell survival in AML.…”

Section: Molecular Subtleties Of Tumor Cell Metabolism: Dysregulation...mentioning

confidence: 99%

Deciphering the Mysterious Relationship between the Cross-Pathogenetic Mechanisms of Neurodegenerative and Oncological Diseases

Aleksandrova,

Neganova

2023

IJMS

View full text Add to dashboard Cite

The relationship between oncological pathologies and neurodegenerative disorders is extremely complex and is a topic of concern among a growing number of researchers around the world. In recent years, convincing scientific evidence has accumulated that indicates the contribution of a number of etiological factors and pathophysiological processes to the pathogenesis of these two fundamentally different diseases, thus demonstrating an intriguing relationship between oncology and neurodegeneration. In this review, we establish the general links between three intersecting aspects of oncological pathologies and neurodegenerative disorders, i.e., oxidative stress, epigenetic dysregulation, and metabolic dysfunction, examining each process in detail to establish an unusual epidemiological relationship. We also focus on reviewing the current trends in the research and the clinical application of the most promising chemical structures and therapeutic platforms that have a modulating effect on the above processes. Thus, our comprehensive analysis of the set of molecular determinants that have obvious cross-functional pathways in the pathogenesis of oncological and neurodegenerative diseases can help in the creation of advanced diagnostic tools and in the development of innovative pharmacological strategies.

show abstract

High Expression of PKM2 Was Associated with the Poor Prognosis of Acute Leukemia

Cited by 7 publications

References 29 publications

A Novel Prognostic Signature of comprising Nine NK Cell signatures Based on Both Bulk RNA Sequencing and Single-Cell RNA Sequencing for Hepatocellular Carcinoma

A Novel Prognostic Signature of comprising Nine NK Cell signatures Based on Both Bulk RNA Sequencing and Single-Cell RNA Sequencing for Hepatocellular Carcinoma

The Role of Reprogrammed Glucose Metabolism in Cancer

Deciphering the Mysterious Relationship between the Cross-Pathogenetic Mechanisms of Neurodegenerative and Oncological Diseases

Contact Info

Product

Resources

About