High Expression of PTGR1 Promotes NSCLC Cell Growth via Positive Regulation of Cyclin-Dependent Protein Kinase Complex

Huang, Xiaobi; Zhou, Weihe; Zhang, Yuefeng; Liu, Yong

doi:10.1155/2016/5230642

Cited by 11 publications

(10 citation statements)

References 51 publications

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“…Moreover, phosphorylation-dependent activity was also found between the proteins in the complex [ 46 – 50 ]. This complex plays an important role in cell cycle control, whereas its deregulation could accelerate tumor growth [ 51 ].…”

Section: Resultsmentioning

confidence: 99%

Network analysis of microRNAs, genes and their regulation in diffuse and follicular B-cell lymphomas

et al. 2018

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MicroRNAs (miRs) are short non-coding regulatory RNAs that control gene expression at the post-transcriptional level and play an important role in cancer development and progression, acting either as oncogenes or as tumor suppressors. Identification of aberrantly expressed miRs in patients with hematological malignancies as compared to healthy individuals has suggested that these molecules may serve as novel clinical diagnostic and prognostic biomarkers.We conducted a systematic literature review of articles published between 2007 and 2017 and re-analyzed experimentally-validated human miR expression signatures in diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) from various biological sources (tumor tissue, peripheral blood, bone marrow and cell lines). A unique miR expression pattern was observed for each disease. Compared to healthy individuals, 61 miRs were aberrantly expressed in DLBCL and 85 in FL; 20-30% of aberrantly expressed miRs overlapped between the two lymphoma subtypes.Analysis of integrative positive and negative miRNA-mRNA relationships using the Ingenuity Pathway Analysis (IPA) system revealed 970 miR-mRNA pairs for DLBCL and 90 for FL. Through gene ontology analysis, we found potential regulatory pathways that are deregulated in DLBCL and FL due to improper expression of miR target genes. By comparing the expression level of the aberrantly expressed miRs in DLBCL to their expression levels in other malignancies, we identified seven miRs that are aberrantly expressed in DLBCL tumor tissues (miR-15a, miR-16, miR-17, miR-106, miR-21, miR-155 and miR-34a-5p). This specific expression pattern may be a potential diagnostic tool for DLBCL.

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Section: Resultsmentioning

confidence: 99%

Network analysis of microRNAs, genes and their regulation in diffuse and follicular B-cell lymphomas

et al. 2018

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“…Furthermore, GCLC plays a crucial role in drug resistance and is considered to be a potential drug target in lung and other cancers [ 40 - 42 ]. Interestingly, another known NRF2-regulated gene, PTGR1 (prostaglandin reductase 1), is highly expressed in NSCLC, promotes cancer cell growth through positive regulation of the cyclin-dependent protein kinase complex, and is considered to be a druggable target in lung and hepatocellular carcinoma [ 43 , 44 ].…”

Section: Discussionmentioning

confidence: 99%

NRF2-regulated metabolic gene signature as a prognostic biomarker in non-small cell lung cancer

Namani

Cui

et al. 2017

Oncotarget

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Mutations in Kelch-like ECH-associated protein 1 (KEAP1) cause the aberrant activation of nuclear factor erythroid-derived 2-like 2 (NRF2), which leads to oncogenesis and drug resistance in lung cancer cells. Our study was designed to identify the genes involved in lung cancer progression targeted by NRF2. A series of microarray experiments in normal and cancer cells, as well as in animal models, have revealed regulatory genes downstream of NRF2 that are involved in wide variety of pathways. Specifically, we carried out individual and combinatorial microarray analysis of KEAP1 overexpression and NRF2 siRNA-knockdown in a KEAP1 mutant-A549 non-small cell lung cancer (NSCLC) cell line. As a result, we identified a list of genes which were mainly involved in metabolic functions in NSCLC by using functional annotation analysis. In addition, we carried out in silico analysis to characterize the antioxidant responsive element sequences in the promoter regions of known and putative NRF2-regulated metabolic genes. We further identified an NRF2-regulated metabolic gene signature (NRMGS) by correlating the microarray data with lung adenocarcinoma RNA-Seq gene expression data from The Cancer Genome Atlas followed by qRT-PCR validation, and finally showed that higher expression of the signature conferred a poor prognosis in 8 independent NSCLC cohorts. Our findings provide novel prognostic biomarkers for NSCLC.

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“…Since cell proliferation is closely related to the cell cycle, we further analyzed cell cycle distribution and found that aspirin significantly increased the cell population in the G0/G1 phase. Cell cycle regulatory proteins play a crucial role in the regulation of the cell cycle [ 37 ]. In tumor cells, the levels of p21 are usually low, which permits unchallenged proliferation.…”

Section: Discussionmentioning

confidence: 99%

Aspirin is Involved in the Cell Cycle Arrest, Apoptosis, Cell Migration, and Invasion of Oral Squamous Cell Carcinoma

Zhang

Feng

et al. 2018

IJMS

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Oral squamous cell carcinoma (OSCC) is one of the most common cancers worldwide. In China, its 5-year survival rate is roughly 50%, owing to acquired chemotherapeutic resistance and metastasis of the disease. Accumulating evidence demonstrates that aspirin (ASA) acts as a preventive or therapeutic agent in multiple cancers; however, anti-tumor activities induced by aspirin are unclear in OSCC. To investigate the possible role of aspirin in OSCC development, we first employed bioinformatics to analyze the anti-OSCC effects of aspirin. We performed a genetic oncology (GO) enrichment analysis using the Database for Annotation, Visualization, and Integrated Discovery (DAVID), and the protein–protein interaction (PPI) network analysis by Cytoscape for differentially expressed genes (DEGs). We also evaluated the potential effects of aspirin on cell proliferation, invasion, migration, and apoptosis in two well-characterized OSCC cell lines (TCA8113 and CAL27). The bioinformatic results revealed that aspirin could inhibit proliferation by blocking the cell cycle, and could reduce migration and invasion via the PI3K-Akt and focal adhesion pathways. We found that ASA could downregulate the OSCC cell proliferation colony formation, invasion, and migration, as well as upregulate apoptosis. Furthermore, we found that ASA suppressed the activation of the focal adhesion kinase (FAK) and the phosphorylation of Akt, NF-κB, and STAT3. Overall, our data suggested that ASA may be developed as a chemopreventive agent to effectively treat OSCC.

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High Expression of PTGR1 Promotes NSCLC Cell Growth via Positive Regulation of Cyclin-Dependent Protein Kinase Complex

Cited by 11 publications

References 51 publications

Network analysis of microRNAs, genes and their regulation in diffuse and follicular B-cell lymphomas

Network analysis of microRNAs, genes and their regulation in diffuse and follicular B-cell lymphomas

NRF2-regulated metabolic gene signature as a prognostic biomarker in non-small cell lung cancer

Aspirin is Involved in the Cell Cycle Arrest, Apoptosis, Cell Migration, and Invasion of Oral Squamous Cell Carcinoma

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