High expression of SGK1 in thrombosis of acute ST-segment elevation myocardial infarction: Based on proteomics analysis of intracoronary thrombosis

Serum Glucocorticoid-Regulated Kinase-1 in Ischemia-Reperfusion Injury: Blessing or Curse

“…Interestingly, a recent study examined SGK-1 expression in intracoronary thrombus in acute STsegment elevation MI of humans (Cai et al, 2022). Initial proteomic analyses revealed significant upregulation of SGK-1 in thrombus which was further confirmed by immunohistochemistry and Western blotting.…”

Identification of the Transcription Factor ATF3 as a Direct and Indirect Regulator of the LDLR

“…The identified network of ATF3 consists of 50 genes. Among those 17 genes have already been shown to have a significant effect on atherosclerosis either as human CAD GWAS candidate gene (LDLR, PLAUR, RGS1, TRIB1 and TSC22D2) or in engineered mouse models (Ccl7, Edn1, Erg1, Erg2, Gdf15, Il1b, Ldlr, Mmp12, Nr4a1, Nr4a2, Plaur, Rgs1, Serpine1, Sgk1, Trib1, Tsc22d2, Vcam1) [18,22,33,[43][44][45][46][47][48][49][50][51][52][53][54][55]. To further elucidate the regulatory capacities and downstream effects of ATF3 on atherosclerosis and CAD relevant genes (e.g., MAFF and LDLR), hierarchical information was implemented in the following step.…”

Os Melhores Artigos de 2022 nos Arquivos Brasileiros de Cardiologia e na Revista Portuguesa de Cardiologia

“…Na fisiopatologia da SCA, a trombose desempenha um papel essencial no desenvolvimento do evento, sendo importante continuar a explorar os mecanismos fisiopatológicos e as vias envolvidas no desencadear do processo de trombose intracoronário. Em um estudo publicado na Revista Portuguesa de Cardiologia, Cai et al 18 analisaram a expressão proteômica de trombos intracoronários extraídos por trombectomia aspirativa de pacientes com SCA com supradesnivelamento do segmento ST (n = 30). Esse estudo é potencialmente relevante porque estudos prévios demonstraram que a análise proteômica pode ser útil na identificação de novos biomarcadores e novos alvos terapêuticos em várias doenças.…”

“…Thrombosis plays an essential role in the pathophysiology of ACS, and it is important to continue exploring the pathophysiological mechanisms and pathways involved in triggering intracoronary thrombosis. In a study published in the Revista Portuguesa de Cardiologia , Cai et al 18 analyzed proteomic expression in intracoronary thrombi extracted by aspiration from patients with ST-segment elevation ACS (n = 30). This report is relevant because previous studies in a number of diseases have shown that proteomic analysis can help identify new biomarkers and new therapeutic targets.…”

“…18 High expression of SGK1 in thrombosis of acute ST-segment elevation myocardial infarction: based on proteomics analysis of intracoronary thrombosis DOI: 10.1016/j.repc.2021.02.023 https://www.revportcardiol.org/pt-high-expression-sgk1-in-thrombosis-articulo-S0870255122000233 Apolinário et al19 Infective endocarditis: Epidemiology and prognosis DOI: 10.1016/j.repc.2021.02.027 https://www.revportcardiol.org/pt-infective-endocarditis-epidemiology-prognosis-articulo-S0870255122000361 Menezes et al20 Development of deep learning segmentation models for coronary X-ray angiography: quality assessment by a new global segmentation score and comparison with human performance DOI: 10.1016/j.repc.2022.04.001 https://www.revportcardiol.org/pt-development-deep-learning-segmentation-models-articulo-S0870255122001354 Abreu et al21 Mechanical circulatory support in children: strategies, challenges and future directions DOI: 10.1016/j.repc.2021.03.011 https://www.revportcardiol.org/pt-mechanical-circulatory-support-in-children-articulo-S0870255121005230 Lanzas et al22 Training program in resuscitation maneuvers delivered by teachers in a school setting: an economic argument DOI: 10.1016/j.repc.2021.02.015 https://www.revportcardiol.org/pt-training-program-in-resuscitation-maneuvers-articulo-S0870255121003772 Hormigo et al23 Protocol-based cardiotoxicity monitoring in hydroxychloroquine medicated COVID-19 pediatric patients DOI: 10.1016/j.repc.2021.01.018 https://www.revportcardiol.org/pt-protocol-based-cardiotoxicity-monitoring-in-hydroxychloroquine-articulo-S0870255121004297 Artigo…”