High Expression of Zinc-Binding Protein-89 Predicts Decreased Survival in Esophageal Squamous Cell Cancer

Yan, Shumei; Wu, Haoran; He, Fan; Hu, Xiaopeng; Zhang, Zhiyi; Huang, Mayan; Wu, Xiao Liang; Huang, Chunyu; Li, Yong

doi:10.1016/j.athoracsur.2014.01.058

Cited by 11 publications

(16 citation statements)

References 20 publications

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“…Although elevated ZBP-89 protein expression correlates with poor survival in colorectal and esophageal adenocarcinomas (17, 18, 22), The Cancer Genome Atlas (TCGA) databases show that the ZNF148 locus that encodes ZBP-89 is mutated in only 1.4% of CRCs (total of 504 cases from 3 databases) (Table S1). To examine ZBP-89 protein expression in the colon at different histological stages, immunohistochemical analysis was performed on 3 sets of colorectal cancer (CRC) tissue arrays.…”

Section: Resultsmentioning

confidence: 99%

“…We previously showed that ZBP-89 forms a protein-protein complex with the tumor suppressor p53 (19) and recent reports indicate that it suppresses p53 function since genetic deletion of one Zfp148 allele increases p53 activity (20, 21). Moreover, other reports have shown that ZBP-89 protein expression promotes esophageal, renal cell and hepatocellular carcinoma (22–24). Since increased ZBP-89 mRNA and protein expression occurs in several cancers including stomach (25) and CRC(17), we hypothesized that the transcription factor likely plays an essential role in tumorigenesis and examined whether ZBP-89 synergizes with Wnt signaling through its ability to regulate CTNNB1 gene expression.…”

Section: Introductionmentioning

confidence: 92%

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Transcription Factor ZBP-89 Drives a Feedforward Loop of β-Catenin Expression in Colorectal Cancer

et al. 2016

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In colorectal cancer (CRC), APC-mediated induction of unregulated cell growth involves post-translational mechanisms that prevent proteasomal degradation of proto-oncogene β-catenin (CTNNB1) and its eventual translocation to the nucleus. However, about 10 percent of colorectal tumors also exhibit increased CTNNB1 mRNA. Here we show in CRC that increased expression of ZNF148, the gene coding for transcription factor ZBP-89, correlated with reduced patient survival. Tissue arrays showed that ZBP-89 protein was overexpressed in the early stages of CRC. Conditional deletion of Zfp148 in a mouse model of Apc-mediated intestinal polyps demonstrated that ZBP-89 was required for polyp formation due to induction of Ctnnb1 gene expression. ChIP and EMSA identified a ZBP-89 binding site in the proximal promoter of CTNNB1. Recipricolly, siRNA-mediated reduction of CTNNB1 expression also decreased ZBP-89 protein. ChIP identified TCF DNA binding sites in the ZNF148 promoter through which Wnt signaling regulates ZNF148 gene expression. Suppression of either ZNF148 or CTNNB1 reduced colony formation in WNT-dependent, but not WNT-independent cell lines. Therefore, the increase in intracellular β–catenin protein initiated by APC mutations is sustained by ZBP-89-mediated feedforward induction of CTNNB1 mRNA.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 92%

Transcription Factor ZBP-89 Drives a Feedforward Loop of β-Catenin Expression in Colorectal Cancer

et al. 2016

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“…Comparison of 328 ESCC tissues with adjacent normal tissues showed a greater expression of tumor necrosis factor receptor–associated protein 1 (TRAP1) in ESCC tissues (77.1%) compared to the adjacent normal tissue (26.9%) . Zinc‐binding protein‐89 (ZBP‐89) was also found to be upregulated in ESCC tissues compared with adjacent normal tissues . Two separate studies found that TFIIB‐related factor 2 (BRF2) and claudin‐2 were highly specific to ESCC tissues compared with normal tissues .…”

Section: Potential Protein Biomarkers For Escc and Precancerous Lesionsmentioning

confidence: 98%

“…OS was defined as the time from the date of surgery to the date of death, as per Refs. , , and . No specific definition provided in other studies.…”

Section: Potential Protein Biomarkers For the Prognosis Of Esccmentioning

confidence: 99%

“…21 Zinc-binding protein-89 (ZBP-89) was also found to be upregulated in ESCC tissues compared with adjacent normal tissues. 22 Two separate studies found that TFIIB-related factor 2 (BRF2) and claudin-2 were highly specific to ESCC tissues compared with normal tissues. 23,24 These findings suggest that these proteins could be potentially novel biomarkers for the diagnosis of ESCC.…”

Section: Potential Protein Biomarkers For the Early Diagnosis Of Esccmentioning

confidence: 99%

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Tissue protein biomarker candidates to predict progression of esophageal squamous cell carcinoma and precancerous lesions

Wang

Smith

Wei

2018

Annals of the New York Academy of Sciences

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Esophageal squamous cell carcinoma (ESCC) is one of the most predominant malignancies worldwide. The 5-year survival rate is still relatively low due to few symptoms presenting with the early disease, diagnosis at middle to late stage, and high risk of recurrence after therapy. Novel protein biomarkers for early detection and treatment of ESCC have the potential to reduce incidence and mortality rates, and significantly prolong the 5-year survival rate. To date, several ESCC biomarkers are being investigated for screening, diagnosis, and treatment to decrease the disease burden. This review summarizes recent developments in candidate protein biomarkers for early diagnosis, predictors for precancerous disease progression, and prognosis of ESCC. Protein biomarkers that enable identification of the different pathologic grades of ESCC will need to be identified. ESCC biomarkers have the potential to improve screening and treatment strategies; multicenter prospective studies with large sample sizes will be required to confirm the usefulness of these candidate biomarkers.

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Invited Commentary

Hagen

2014

The Annals of Thoracic Surgery

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High Expression of Zinc-Binding Protein-89 Predicts Decreased Survival in Esophageal Squamous Cell Cancer

Cited by 11 publications

References 20 publications

Transcription Factor ZBP-89 Drives a Feedforward Loop of β-Catenin Expression in Colorectal Cancer

Transcription Factor ZBP-89 Drives a Feedforward Loop of β-Catenin Expression in Colorectal Cancer

Tissue protein biomarker candidates to predict progression of esophageal squamous cell carcinoma and precancerous lesions

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