High‐fat diet‐ and angiotensin II‐induced aneurysm concurrently elicits splenic hypertrophy

Abstract

Our study provides evidence that Ang II infusion and high-fat supplementation induces abdominal aortic aneurysm that has pathological implications to the spleen. The use of β-carotene but not α-tocopherol as an antioxidant markedly ameliorates the pathological changes in spleen.

Attrition of Hepatic Damage Inflicted by Angiotensin II with α-Tocopherol and β-Carotene in Experimental Apolipoprotein E Knock-out Mice

“…Further, expression of caspase 3 and p53 was also suggestive of apoptosis of hepatocytes in the Ang II-treated experimental Apoe −/− mice showing evidence of hepatic damage. We also convincingly showed that the expressions of CK-19, caspase 3 and p53 were markedly controlled by β-carotene treatment in the Apoe −/− mice reflecting the beneficial role of antioxidants 11 18 against hepatic damage.…”

“…Interestingly, our investigation also found that ROS release was significantly controlled by β-carotene dietary supplementation. This salubrious role of β-carotene treatment in the Apoe −/− mice reflects the beneficial role of antioxidants 11 18 against hepatic damage.…”

“…We recently showed that macrophage and lymphocyte infiltration could play a crucial role in facilitating the inflammation in Ang II-mediated pathology involving the aorta, brain and kidney 4 10 11 12 . Therefore, here we investigated the potential role of macrophages and CD4 + cells in Ang II-induced hepatic damage in Apoe −/− mice.…”

“…The diet was stored at 4 o C and mice feed pellet were changed once in two days to minimize the oxidation and degradation of antioxidants. After 60 days, the antioxidant-treated animals and control animals were sacrificed as per standard procedures 11 .…”

An association of spleen volume and aortic diameter in patients and in mice with abdominal aortic aneurysm

“…Currently, it has been proved that Angiotensin II (Ang II)–induced inflammatory reactions will cause splenic enlargement in Ang II/APOE model [ 12 , 13 ]. Further study revealed that splenectomy before Ang II delivery would inhibit early monocyte subset mobilization into the blood and protect against AAA in experimental AAA model [ 8 ].…”