2023
DOI: 10.1007/s10911-023-09548-8
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High-fat diet, but not duration of lactation, increases mammary gland lymphatic vessel function and subsequent growth of inflammatory breast cancer cells

Wintana Balema,
Janelle Morton,
Richard A. Larson
et al.

Abstract: Inflammatory breast cancer (IBC) presents as rapid-onset swelling and breast skin changes caused by tumor emboli in the breast and breast skin lymphatics. IBC has been linked with obesity and duration of breastfeeding, but how these factors affect IBC tumor progression is not clear. We modeled the simultaneous effects of diet and weaning in mice on in vivo lymphatic function; on IBC tumor growth; and on aspects of the mammary gland microenvironment before and after IBC (SUM149) xenograft inoculation. We hypoth… Show more

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“…In this special issue of The Journal of Mammary Gland Biology and Neoplasia we have collected contributions on the involvement of the lymphatic system in normal mammary gland physiology and breast cancer metastasis as well as cancer patient recovery. There are four articles which span the range from clinical implications of axillary lymph node dissection (Kinney et al [ 3 ]) to the impact of lifestyle factors such as diet and duration of lactation (Balema et al [ 4 ]), to basic science implicating lymphatic secretions in attraction of breast cancer cells (Giotopoulou et al [ 5 ]) and finally a comprehensive literature review of lymphatic remodeling that occurs during mammary development and breast cancer progression (Dahms and Lyons [ 6 ]).…”
mentioning
confidence: 99%
“…In this special issue of The Journal of Mammary Gland Biology and Neoplasia we have collected contributions on the involvement of the lymphatic system in normal mammary gland physiology and breast cancer metastasis as well as cancer patient recovery. There are four articles which span the range from clinical implications of axillary lymph node dissection (Kinney et al [ 3 ]) to the impact of lifestyle factors such as diet and duration of lactation (Balema et al [ 4 ]), to basic science implicating lymphatic secretions in attraction of breast cancer cells (Giotopoulou et al [ 5 ]) and finally a comprehensive literature review of lymphatic remodeling that occurs during mammary development and breast cancer progression (Dahms and Lyons [ 6 ]).…”
mentioning
confidence: 99%