High Fat Diet During Pregnancy And Lactation Induces Hypertension In Adult Offspring Rats

Abstract

An adequate nutritional support is important to ensure a normal development of the fetuses. Changes in the nutritional support during gestation may lead to transitory or permanent structural and functional changes of several organs of the offspring. We aimed to investigate the impact of a high fat diet during the gestation on cardiovascular and autonomic nervous systems (ANS) in the offspring of rats. High fat diet was given from day 1 of gestation until weaning of puppies. Sixty‐day‐old offspring from High Fat Diet dams (HFDD, n= 6) or Normal Diet dams (NDD, n= 6) had femoral arteries surgically assessed for the measurements of heart rate (HR), mean (MAP), systolic (SAP) and diastolic arterial pressure (DAP), and spontaneous baroreflex sensitivity (BRS). To investigate the balance of ANS, we established the high (HF) and low frequency (LF) bands of pulse interval (PI) and LF band of SAP spectrum. HFDD had increased MAP (135 ± 2vs 103± 1 mmHg, p<0.05), SAP (160 ± 3 vs 128 ± 4 mmHg, p<0.05), DAP (111 ± 2vs 91 ± 2 mmHg, p<0.05) and HR (417 ± 23 vs 352 ± 8 bpm, p<0.05) when compared to NDD. After spectral analysis of PI and SAP, LF band of SAP spectrum (6.19 ± 0.84 vs 2.29 ± 0.56 mmHg2, p<0.05) and LF/HF ratio of PI (0.71 ± 0.22 vs 0.14 ± 0.016 p<0.05) was higher in HFDD under spontaneous condition. These findings suggest that high fat diet during pregnancy and lactation leads to autonomic misbalance and hypertension in adult offspring rats.

Comparative Study between ABNT/NBR 15270/2005 and a New Hollow Ceramic Block for Non-Load-Bearing Masonry Manufactured in Santarém - Pará (Brazil)

“…Among the factors responsible for this are the extrusion process, the extruder die itself and the drying process, since the geometry of the block in question can generate deformations with the material's own weight. This information is of significant importance for the standardization of parts and consumer use, so much so that the bibliography [10] describes that all ceramic blocks only meet the appearance evaluation criteria, since they did not present breaks, irregular surfaces or deformations. The post-confection and transport phase contribute to the worsening of the deformations [11].…”

“…Pilz et al (2015) [11] also found similar problems in traditional blocks, when 60% of the brands studied did not reach the minimum value of 1.5 MPa. Santos et al (2011) [10] corroborate this by indicating that the ceramics studied also do not reach the minimum necessary.…”