High-fat-diet–induced obesity is associated with decreased antiinflammatory Lactobacillus reuteri sensitive to oxidative stress in mouse Peyer's patches

Sun, Jin; Qiao, Yi; Cui, Qi; Jiang, Wei; Xiao, Hang; Shi, Yonghui; Li, Guowei

doi:10.1016/j.nut.2015.08.020

Cited by 57 publications

(33 citation statements)

References 43 publications

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“…Induction of retinoic acid metabolism is crucial for certain probiotic microbes to modulate dendritic cells function . In the present study, we found that L. reuteri is the dominant PP Lactobacillus in rats, which was consistent with our previous findings in mice . This suggested the importance of this species on PP function of rodents and possibly of human due to the species has been considered autochthonous to the human digestive tract .…”

Section: Discussionsupporting

confidence: 92%

“…Among the Lactobacillus, Lactobacillus reuteri was the most abundant species in the mouse PP. In the obesity prone mice, the abundance of L. reuteri strain sensitive to oxidative stress with IL-10 stimulating ability was significantly lower than that in the obesity-resistant mice [5]. Our results also confirmed that oral administration of L. reuteri of this phenotype significantly decreased the susceptibility of mice to obesity induced by high fat diet [6].…”

Section: Introductionsupporting

confidence: 82%

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Isolation of lactobacillus reuteri from Peyer's patches and their effects on sIgA production and gut microbiota diversity

Wang

Xiao

et al. 2016

Molecular Nutrition Food Res

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Section: Discussionsupporting

confidence: 92%

Section: Introductionsupporting

confidence: 82%

Isolation of lactobacillus reuteri from Peyer's patches and their effects on sIgA production and gut microbiota diversity

Wang

Xiao

et al. 2016

Molecular Nutrition Food Res

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“…It has been reported that the HFD also led to decreased Lactobacillus enrichment in the gut microbiome. Lactobacillus has also been demonstrated to possess bioactivities, including antioxidant, anti‐obesity, anti‐inflammatory, and anti‐insulin resistance effects . In the present study, the Lactobacillus level was negatively correlated with serum LPS level ( r = −0.76, p < 0.05).…”

Section: Discussionsupporting

confidence: 48%

Mannan Oligosaccharide Suppresses Lipid Accumulation and Appetite in Western‐Diet‐Induced Obese Mice Via Reshaping Gut Microbiome and Enhancing Short‐Chain Fatty Acids Production

Yan

Shi

et al. 2019

Molecular Nutrition Food Res

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Scope Obesity is associated with gut microbiome dysbiosis. Mannose oligosaccharide (MOS) has been reported to be a potential prebiotic. The present study is aimed to determine the effects of MOS on western‐diet‐induced obesity and to uncover the mediating roles of the gut microbiota and microbial metabolites. Methods and results Three‐month‐old male ICR mice are fed with a high‐fat and high‐fructose diet for 8 weeks. The diet‐induced obese mice are then orally administrated with MOS (100 and 200 mg kg–1 d–1) for 4 weeks. MOS significantly reduces bodyweight gain, insulin resistance, fatty liver, and inflammatory responses in obese mice. MOS also stimulates lipolysis and inhibits lipogenesis in the adipose tissues. Moreover, MOS restructures the gut microbiome by enhancing the abundance of Bifidobacterium and Lactobacillus in obese mice. The microbial metabolite SCFAs are also increased in the feces and serum. Correlation analysis indicates that the appetite suppression and lipid‐lowering effects of MOS are highly correlated with the butyrate levels. Conclusion MOS suppresses the appetite, which results in less lipid deposition. The lower appetite is likely due to an altered gut microbiome and elevated SCFAs production. MOS may be a potential nutraceutical used in body weight management and gut health improvement.

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“…A decrease in Lactobacillus abundance might affect the level of uremic toxin. The lowest proportion of these beneficial bacteria was found in hamsters fed on the MSG+HFF diet, consistent with results from previous reports [20,69]. In contrast, relative abundance of pathogenic bacteria, such as members of the Escherichia-Shigella (MN326536) genus, increased in hamsters given the MSG and/or the HFF diet.…”

Section: Plos Onesupporting

confidence: 91%

A combination of monosodium glutamate and high-fat and high-fructose diets increases the risk of kidney injury, gut dysbiosis and host-microbial co-metabolism

et al. 2020

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Consumption of either monosodium glutamate (MSG) or high-fat and high-fructose (HFF) diets changes the gut microbiome and hence contributes to development of several diseases. In this study, with an emphasis on kidney injury, hamsters were divided into 4 groups as follows: (1) hamsters fed with standard diet (control); (2) hamsters fed with standard diet and MSG in drinking water (MSG); (3) hamsters fed with high-fat and high-fructose diets (HFF), and (4) animals fed MSG+HFF. After 8 months, the animals were used for the study. Despite showing normal kidney function, hamsters fed with MSG+HFF exhibited signs of kidney damage as demonstrated by the highest expression levels of high-mobility group box-1 and kidney injury molecule-1 in kidney tissues, while slight changes of histopathological features in H&E-stained sections and normal levels of creatinine were observed, indicating possible early stages of kidney injury. Sequencing of the microbial 16S rRNA gene revealed that animals fed with the MSG+HFF diet had a higher ratio of gut Firmicutes/Bacteroidetes along with marked changes in abundance and diversity of gut microbiome compared to hamsters fed with MSG or HFF alone. In addition, 1 H Nuclear magnetic resonance spectroscopy showed an elevation of urine p-cresol sulfate levels in the MSG+HFF group. These results indicate that consumption of both MSG and HFF increases the risk of kidney injury, induces gut dysbiosis and an increase in the amount of p-cresol sulfate in hamsters.

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High-fat-diet–induced obesity is associated with decreased antiinflammatory Lactobacillus reuteri sensitive to oxidative stress in mouse Peyer's patches

Cited by 57 publications

References 43 publications

Isolation of lactobacillus reuteri from Peyer's patches and their effects on sIgA production and gut microbiota diversity

Isolation of lactobacillus reuteri from Peyer's patches and their effects on sIgA production and gut microbiota diversity

Mannan Oligosaccharide Suppresses Lipid Accumulation and Appetite in Western‐Diet‐Induced Obese Mice Via Reshaping Gut Microbiome and Enhancing Short‐Chain Fatty Acids Production

A combination of monosodium glutamate and high-fat and high-fructose diets increases the risk of kidney injury, gut dysbiosis and host-microbial co-metabolism

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