High-fat diet-induced obesity is attenuated by probiotic strain Lactobacillus paracasei ST11 (NCC2461) in rats

Tanida, Mamoru; Shen, Jiao; Maeda, Keisuke; Horii, Yuko; Yamano, Toshìo; Fukushima, Yoichi; Nonomura, Katsuya

doi:10.1016/j.orcp.2008.04.003

Cited by 88 publications

(88 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Lactic acid bacteria have not been reported to elevate body temperature in humans. The body temperature of rats increased after feeding with lactic acid bacteria (Tanida et al, 2008), and the body temperature of humans increases by 1.8 − 3.4℃ from baseline after the administration of E. coli LPS, and this is accompanied by chills, headache and nausea (Soop et al, 2004;Fijen et al, 2001). The maximum increase in chest temperature in the present study after LP14 and placebo ingestion was 0.46℃ and 0.22℃, respectively, from baseline without subjective symptoms.…”

Section: Discussionsupporting

confidence: 42%

“…β3 agonists promote lipolysis in white adipocytes, activate UCP1, change free fatty acids into heat and decrease body fat (Sasaki et al, 1998). Injected Lactobacillus paracasei ST11 also elevates sympathetic nerve activity, blood pressure and temperature in the rat abdominal cavity and BAT, reduces abdominal fat (Tanida et al, 2008). L. paracasei ST11 affects the hypothalamic suprachiasmatic nucleus (SCN) of the brain and causes sympathetic elevation.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Thermogenesis by Lactobacillus plantarum No. 14 in Japanese Subjects

Nagata

Yoshida²,

Araki

et al. 2012

FSTR

View full text Add to dashboard Cite

The effects of single administration of Lactobacillus plantarum No. 14 (LP14) on human body temperature and factors related to sympathetic nerves were measured in a randomized, double-blind, cross-over study. LP14 significantly increased chest temperature (P < 0.05). The maximum difference in temperature between LP14 and placebo was 0.24 ± 0.24℃. Systolic blood pressure increased significantly, and arousal scores tended to increase in the LP14 group. The results of the Uchida-Kraepelin test indicated that LP14 elevated task performance. Our results demonstrated that LP14 induced thermogenesis in humans. We also examined the activity of the sympathetic nerves (SNA) innervating brown adipose tissue (BAT) in rats. The activity of BAT-SNA was significantly enhanced in the LP14 group. As LP14 changed factors associated with sympathetic nerves in humans and elevated sympathetic nerve activity in rats, sympathetic nerve activation appears to participate in thermogenesis elicited by LP14.

show abstract

Section: Discussionsupporting

confidence: 42%

Section: Resultsmentioning

confidence: 99%

Thermogenesis by Lactobacillus plantarum No. 14 in Japanese Subjects

Nagata

Yoshida²,

Araki

et al. 2012

FSTR

View full text Add to dashboard Cite

show abstract

“…Thus, although Lactobacillus gasseri SBT2055 was not one of the VSL#3 probiotic strains, it is possible that fat mass increased less in the present study through a reduction in lipid absorption (26,29) following the probiotic treatment. Finally, VSL#3 may have increased energy expenditure and whole body fat oxidation (32) via GLP-1 secretion (12), increased angiopoietin-like protein-4 (inhibitor of lipoprotein lipase) (33), and/or increased sympathetic nervous system activity to white and brown adipose tissue (34). Future studies will be necessary to determine the mechanism(s).…”

Section: Discussionmentioning

confidence: 99%

Probiotic supplementation attenuates increases in body mass and fat mass during high‐fat diet in healthy young adults

Osterberg

Boutagy

McMillan

et al. 2015

Obesity

View full text Add to dashboard Cite

Objective: The objective was to determine the effects of the probiotic, VSL#3, on body and fat mass, insulin sensitivity, and skeletal muscle substrate oxidation following 4 weeks of a high-fat diet. Methods: Twenty non-obese males (18-30 years) participated in the study. Following a 2-week eucaloric control diet, participants underwent dual X-ray absorptiometry to determine body composition, an intravenous glucose tolerance test to determine insulin sensitivity, and a skeletal muscle biopsy for measurement of in vitro substrate oxidation. Subsequently, participants were randomized to receive either VSL#3 or placebo daily during 4 weeks of consuming a high-fat (55% fat), hypercaloric diet (11,000 kcal day 21). Participants repeated all measurements following the intervention. Results: Body mass (1.42 6 0.42 kg vs. 2.30 6 0.28 kg) and fat mass (0.63 6 0.09 kg vs. 1.29 6 0.27 kg) increased less following the high-fat diet in the VSL#3 group compared with placebo. However, there were no significant changes in insulin sensitivity or in vitro skeletal muscle pyruvate and fat oxidation with the high-fat diet or VSL#3. Conclusions: VSL#3 supplementation appears to have provided some protection from body mass gain and fat accumulation in healthy young men consuming a high-fat and high-energy diet.

show abstract

“…Recent experimental studies have demonstrated the preventive effects on obesity of some lactic acid bacterial strains. 4,5) In particular, certain Lactobacillus ferments have been found to lower the plasma triacylglycerol level and body weight in high-fat diet-fed rodents, probably because of modified lipid absorption and metabolism. [6][7][8] This merits further investigation of the effects of lactobacillus ferments on dietary fat absorption in the intestines.…”

mentioning

confidence: 99%