High-Fat-Diet–Induced Oxidative Stress Linked to the Increased Colonization of Lactobacillus sakei in an Obese Population

Jeeyon, Lee; Bae, Eunsoo; Kim, Hwa Young; Lee, Kang-Mu; Yoon, Sang Sun; Lee, Duk Chul

doi:10.1128/spectrum.00074-21

Cited by 11 publications

(9 citation statements)

References 52 publications

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“…Given the diversity of host defense factors affected by the HFHCD, most likely multiple mechanisms are underlying the drop in host defense factors expression. High‐fat diets have been shown to induce ER stress, impairment of mitochondrial biogenesis, and oxidative stress in the colonic epithelium, (Gulhane et al, 2016; Lee et al, 2021; Li et al, 2019; Yoo et al, 2021), which could drive dysfunction of multiple epithelial cell types. In addition to that, changes in host immunity, host metabolism and variations in the bacterial metabolome as a result of changes in the composition of microbial communities can also have a strong influence in epithelial cells function.…”

Section: Discussionmentioning

confidence: 99%

“…It has been proposed that high‐fat diets cause endoplasmic reticulum stress in goblet cells by the direct action of nonesterified fatty acids, with a negative impact in goblet cells function (Gulhane et al, 2016). In addition, they can induce mucosal oxidative stress, which in turns promotes inflammation and barrier permeability (Lee et al, 2021; Li et al, 2019). Changes in the repertoire of mucosal and intraepithelial immune cells have also been documented upon high fat diet interventions, with reported increases in the number of intraepithelial NK cells and non‐CD1d‐restricted NKT cells (Ma et al, 2008), changes in the relative abundance of distinct mucosal DC subsets (Cheng et al, 2016) and decreases in the number of lamina propria IgA‐producing plasma cells (Luck et al, 2019), lamina propria lymphocytes (Tanaka et al, 2020), intraepithelial lymphocytes (Soares et al, 2015), mucosal and intraepithelial Tregs (Ma et al, 2008), and Th17 cells (Garidou et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Defects in the expression of colonic host defense factors associate with barrier dysfunction induced by a high‐fat/high‐cholesterol diet

Valdes

Gagné‐Sansfaçon

Reyes

et al. 2022

The Anatomical Record

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The effect of Western diets in the gastrointestinal system is largely mediated by their ability to promote alterations in the immunity and physiology of the intestinal epithelium, and to affect the composition of the commensal microbiota. To investigate the response of the colonic epithelium to high-fat/highcholesterol diets (HFHCDs), we evaluated the synthesis of host defense factors involved in the maintenance of the colonic homeostasis. C57BL/6 mice were fed an HFHCD for 3 weeks and their colons were evaluated for histopathology, gene expression, and microbiota composition. In addition, intestinal permeability and susceptibility to Citrobacter rodentium were also studied. HFHCD caused colonic hyperplasia, loss of goblet cells, thinning of the mucus layer, moderate changes in the composition of the intestinal microbiota, and an increase in intestinal permeability. Gene expression analyses revealed significant drops in the transcript levels of Muc1,

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Defects in the expression of colonic host defense factors associate with barrier dysfunction induced by a high‐fat/high‐cholesterol diet

Valdes

Gagné‐Sansfaçon

Reyes

et al. 2022

The Anatomical Record

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“…Significantly, various antidiabetic interventions targeting the gut microbiota are being explored (Figure 5). Among them, the most promising ones for clinical application are probiotics and prebiotics (Lee Y. et al, 2021;Watanabe et al, 2021). Lactobacillus rhamnosus LRa05 reduced fasting blood glucose and insulin resistance by regulating the composition of the gut microbiota in T2DM mice (Wu et al, 2021).…”

Section: Conclusion and Future Perspectivementioning

confidence: 99%

“…The gut microbiota is involved in obesity, non-alcoholic fatty liver (NAFL), insulin resistance and chronic inflammation, which are related to the development of T2DM ( Saad et al, 2016 ; Mouries et al, 2019 ; Lee J.Y. et al, 2021 ).…”

Section: Gut Microbiota and T2dmmentioning

confidence: 99%

Gut Microbiota: An Important Player in Type 2 Diabetes Mellitus

Zhou

Sun

et al. 2022

Front. Cell. Infect. Microbiol.

133

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Type 2 diabetes mellitus (T2DM) is one of the common metabolic diseases in the world. Due to the rise in morbidity and mortality, it has become a global health problem. To date, T2DM still cannot be cured, and its intervention measures mainly focus on glucose control as well as the prevention and treatment of related complications. Interestingly, the gut microbiota plays an important role in the development of metabolic diseases, especially T2DM. In this review, we introduce the characteristics of the gut microbiota in T2DM population, T2DM animal models, and diabetic complications. In addition, we describe the molecular mechanisms linking host and the gut microbiota in T2DM, including the host molecules that induce gut microbiota dysbiosis, immune and inflammatory responses, and gut microbial metabolites involved in pathogenesis. These findings suggest that we can treat T2DM and its complications by remodeling the gut microbiota through interventions such as drugs, probiotics, prebiotics, fecal microbiota transplantation (FMT) and diets.

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“…Probiotics are a group of bacteria that play a crucial role in gut microbiota homeostasis. They are recognized to be valuable in preventing various diseases including inflammatory bowel disease, which is related to ROS levels in animal models [66] . Certain gut bacteria are linked to greater levels of ROS induced by higher fat intake [67] .…”

Section: Probiotics As a Therapeutic Intermediation Against Cancermentioning

confidence: 99%

Roles of gut dysbiosis, anti-proliferative proteins, and post-transcriptional regulation in carcinogenesis

Sawamura¹,

Taniguchi²,

Ikeda³

et al. 2022

J Transl Genet Genom

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The potentially powerful impact of microbiota has attracted much attention. For example, dysbiosis of the gut microbiota could be linked to various cancers. It is probable that DNA damage and DNA repair impairment due to inflammation from gut dysbiosis would be of importance in carcinogenesis and/or preventing carcinogenesis. In fact, the signature of the gut microbiome has been shown to be associated with responses and/or successful survival rate to certain immune-blockade therapy in several cancers. Conversely, living cells have to cope with the danger of reactive oxygen species (ROS) disturbing the integrity of biomolecules, which can eventually lead to carcinogenesis if otherwise untreated. Gut microbiota could modulate considerable levels of ROS and oxidative damage. Interestingly, an anti-proliferative family (APRO) characterized by several immediate early responsive gene products might be deeply involved in the mechanism of carcinogenesis. It has been described that APRO proteins also participate in a variety of cellular processes including cell division, DNA repair, and mRNA stability. The biological function of APRO proteins seems to be quite complicated; however, they might be a key modulator of microRNAs (miRNAs) for post-transcriptional regulation. The next generation of therapy would likely contain strategies for modifying the redox background as well as the regulation of ROS in cells and/or for better DNA repair machinery with the APRO proteins via the modulation of miRNA-derived post-transcriptional regulation in a sustainable manner. Given the important function of the gut microbiota in balancing the immune network, carcinogenesis could therefore be prevented by suitable gut microbiota via the roles of APRO proteins. Consequently, probiotics might play a key role in the modulation of gut immune system in keeping healthy and/or preventing cancers.

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High-Fat-Diet–Induced Oxidative Stress Linked to the Increased Colonization of Lactobacillus sakei in an Obese Population

Abstract: Lactobacillus provides many health benefits; its various species are widely used as probiotics. However, an increased abundance of Lactobacillus has been reported in obesity, and the role of Lactobacillus strains in obesity remains unknown.

Cited by 11 publications

References 52 publications

Defects in the expression of colonic host defense factors associate with barrier dysfunction induced by a high‐fat/high‐cholesterol diet

Defects in the expression of colonic host defense factors associate with barrier dysfunction induced by a high‐fat/high‐cholesterol diet

Gut Microbiota: An Important Player in Type 2 Diabetes Mellitus

Roles of gut dysbiosis, anti-proliferative proteins, and post-transcriptional regulation in carcinogenesis

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