High-Fat Diet Influences Dendritic Cells and T-Cell Infiltration in Apical Periodontitis in Mice

Shrestha, Annie; Zhu, Yi; Ali, Aiman

doi:10.1016/j.joen.2024.01.015

Journal of Endodontics

2024

DOI: 10.1016/j.joen.2024.01.015

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High-Fat Diet Influences Dendritic Cells and T-Cell Infiltration in Apical Periodontitis in Mice

Annie Shrestha,

Yi Zhu,

Aiman Ali

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2024

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Cited by 3 publications

References 37 publications

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The role of 27-hydroxycholesterol in hypercholesterolemia-associated exacerbation of apical periodontitis and therapeutic potential of felodipine

Yang,

Wang,

Lin

et al. 2024

Journal of Dental Sciences

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The role of 27-hydroxycholesterol in hypercholesterolemia-associated exacerbation of apical periodontitis and therapeutic potential of felodipine

Yang,

Wang,

Lin

et al. 2024

Journal of Dental Sciences

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Insights into the April 2024 Issue of the Journal of Endodontics

Aminoshariae,

Azarpazhooh,

Fouad

et al. 2024

Journal of Endodontics

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The immune landscape in apical periodontitis: From mechanism to therapy

Wen,

Lin,

Zhou

et al. 2024

Int Endodontic J

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Apical periodontitis (AP) is featured by a persistent inflammatory response and alveolar bone resorption initiated by microorganisms, posing risks to both dental and systemic health. Nonsurgical endodontic treatment is the recommended treatment plan for AP with a high success rate, but in some cases, periapical lesions may persist despite standard endodontic treatment. Better comprehension of the AP inflammatory microenvironment can help develop adjunct therapies to improve the outcome of endodontic treatment. This review presents an overview of the immune landscape in AP, elucidating how microbial invasion triggers host immune activation and shapes the inflammatory microenvironment, ultimately impacting bone homeostasis. The destructive effect of excessive immune activation on periapical tissues is emphasized. This review aimed to systematically discuss the immunological basis of AP, the inflammatory bone resorption and the immune cell network in AP, thereby providing insights into potential immunotherapeutic strategies such as targeted therapy, antioxidant therapy, adoptive cell therapy and cytokine therapy to mitigate AP‐associated tissue destruction.

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High-Fat Diet Influences Dendritic Cells and T-Cell Infiltration in Apical Periodontitis in Mice

Cited by 3 publications

References 37 publications

The role of 27-hydroxycholesterol in hypercholesterolemia-associated exacerbation of apical periodontitis and therapeutic potential of felodipine

The role of 27-hydroxycholesterol in hypercholesterolemia-associated exacerbation of apical periodontitis and therapeutic potential of felodipine

Insights into the April 2024 Issue of the Journal of Endodontics

The immune landscape in apical periodontitis: From mechanism to therapy

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