High-fat Diets Containing Soybean or Canola Oil Affect Differently Pancreas Function of Young Male Rats

Costa, Cristiane; Carlos, Aluana Santana; Santos, Ana Sílvia Pereira; Moura, Egberto Gaspar de; Nascimento-Saba, Celly Cristina Alves do

doi:10.1055/s-0033-1345150

Cited by 7 publications

(4 citation statements)

References 11 publications

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“…In the figure 25 , the 19C (19% canola oil) group showed higher insulin resistance (HOMA-IR) and more damage to pancreas β-cells than the 19S (19% soybean oil) and 7S (control) groups. The 19C group presented lower percentage of pancreatic islets area in comparison to 19S (-41%) and 7S group (-70%, p < 0.0001) [51] . DM patients in Japan are characterized by exhibiting both insulin resistance and impaired insulin secretion.…”

Section: Link Between the Survival-shortening Activity Of Fats And Oimentioning

confidence: 74%

“…Similarly, these 2 vegetable oils differentially affected oxidative stress-related enzymes in erythrocytes and vascular properties in the SHRSP rat [52] . da Costa et al [51] ascribed the difference in these parameters observed between the canola and soybean oil groups to the difference in the proportion of monounsaturated oleic acid and polyunsaturated linoleic acid ( fig. 25 ).…”

Section: Link Between the Survival-shortening Activity Of Fats And Oimentioning

confidence: 99%

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Medicines and Vegetable Oils as Hidden Causes of Cardiovascular Disease and Diabetes

Okuyama

Langsjoen²,

Ohara

et al. 2016

Pharmacology

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Background: Positive associations have been observed between cardiovascular disease (CVD) and type 2 diabetes mellitus (DM), but their causal relationship has not been clarified. Nevertheless, guidelines from relevant medical societies recommend using cholesterol lowering medication (statin) for both types of patients. Medicines with several different action mechanisms have been developed, and the effectiveness of different lifestyle modifications has been studied extensively for the prevention of DM, which was successful in improving clinical marker status in relatively short-term treatments, but none have been shown to be effective in improving long-term outcomes (mortality from CVD and all causes). Summary: Statin-induced suppression of prenyl intermediates in the cholesterol biosynthetic pathway has been linked to stimulated atherosclerosis and heart failure. On the other hand, certain types of vegetable oil and hydrogenated oil shortened the survival of stroke-prone spontaneously hypertensive rats by decreasing platelet number, increasing hemorrhagic tendency and damaging kidney functions, which could not be accounted for by their fatty acid and phytosterol compositions. These vegetable oils and medicines such as statin and warfarin share, in part, a common mechanism to inhibit vitamin K₂-dependent processes, which was interpreted to lead to increased onset of CVD, DM, chronic kidney disease, bone fracture and even mental disorder. Impaired vitamin K₂-dependent processes by some types of vegetable oils and medicines, but not plasma high low density lipoprotein cholesterol, were proposed as the cause of CVD, DM and other lifestyle-related diseases. High n-6/n-3 fatty acid ratio of ingested foods, but not animal fats, was emphasized to be another risk factor for many of the diseases described above. Key Messages: To date, no randomized controlled trials (RCTs) have been performed to prove the above interpretation. However, the opposite types of RCT trials have been performed by increasing the intake of high-linoleic vegetable oils and reducing that of animal fats, which resulted in increased CVD and all-cause mortality. The amounts of these vegetable oils to exhibit adverse effects in animal studies are not huge (<6 energy %), which should not be overlooked nor disregarded.

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Section: Link Between the Survival-shortening Activity Of Fats And Oimentioning

confidence: 74%

Section: Link Between the Survival-shortening Activity Of Fats And Oimentioning

confidence: 99%

Medicines and Vegetable Oils as Hidden Causes of Cardiovascular Disease and Diabetes

Okuyama

Langsjoen²,

Ohara

et al. 2016

Pharmacology

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“…As an example, MUFA‐rich macadamia oil (80% w/w) increased whole body adiposity in high‐carbohydrate, high‐fat diet‐induced model of metabolic syndrome . Similarly, high‐fat diet containing oleic acid‐rich canola oil increased abdominal fat in young rats . Pig lard and beef tallow, usually containing 40–50% oleic acid, both increase adiposity in rats and mice and are commonly used animal models of diet‐induced obesity .…”

Section: Fatty Acids: Saturated N‐9 N‐6 and N‐3 Fatty Acidsmentioning

confidence: 99%

Functional foods as potential therapeutic options for metabolic syndrome

2015

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Obesity as part of metabolic syndrome is a major lifestyle disorder throughout the world. Current drug treatments for obesity produce small and usually unsustainable decreases in body weight with the risk of major adverse effects. Surgery has been the only treatment producing successful long-term weight loss. As a different but complementary approach, lifestyle modification including the use of functional foods could produce a reliable decrease in obesity with decreased comorbidities. Functional foods may include fruits such as berries, vegetables, fibre-enriched grains and beverages such as tea and coffee. Although health improvements continue to be reported for these functional foods in rodent studies, further evidence showing the translation of these results into humans is required. Thus, the concept that these fruits and vegetables will act as functional foods in humans to reduce obesity and thereby improve health remains intuitive and possible rather than proven.

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“…Some studies have analyzed the effects of SO on obesity and diabetes; however, the results have been divergent. [ 14–16 ] Although these guidelines are still in force today, [ 3 ] recent literature has discussed about which type of fat would be the most harmful to health. [ 17 ] Studies indicate that saturated fat from sources such as CO, which in turn is rich in MCFAs, can play a beneficial role in both the prevention and treatment of metabolic syndrome.…”

Section: Introductionmentioning

confidence: 99%

Low‐Dose Coconut Oil Supplementation Induces Hypothalamic Inflammation, Behavioral Dysfunction, and Metabolic Damage in Healthy Mice

Verás

Santos

Martins

et al. 2021

Molecular Nutrition Food Res

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Scope: Coconut oil (CO) diets remain controversial due to the possible association with metabolic disorder and obesity. This study investigates the metabolic effects of a low amount of CO supplementation. Methods and Results: Swiss male mice are assigned to be supplemented orally during 8 weeks with 300 µL of water for the control group (CV), 100 or 300 µL of CO (CO100 and CO300) and 100 or 300 µL of soybean oil (SO; SO100 and SO300). CO led to anxious behavior, increase in body weight gain, and adiposity. In the hypothalamus, CO and SO increase cytokines expression and pJNK, pNFKB, and TLR4 levels. Nevertheless, the adipose tissue presented increases macrophage infiltration, TNF-and IL-6 after CO and SO consumption. IL-1B and CCL2 expression, pJNK and pNFKB levels increase only in CO300. In the hepatic tissue, CO increases TNF-and chemokines expression. Neuronal cell line (mHypoA-2/29) exposed to serum from CO and SO mice shows increased NFKB migration to the nucleus, TNF-, and NFKBia expression, but are prevented by inhibitor of TLR4 (TAK-242). Conclusions: These results show that a low-dose CO changes the behavioral pattern, induces inflammatory pathway activation, TLR4 expression in healthy mice, and stimulates the pro-inflammatory response through a TLR4-mediated mechanism.

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High-fat Diets Containing Soybean or Canola Oil Affect Differently Pancreas Function of Young Male Rats

Cited by 7 publications

References 11 publications

Medicines and Vegetable Oils as Hidden Causes of Cardiovascular Disease and Diabetes

Medicines and Vegetable Oils as Hidden Causes of Cardiovascular Disease and Diabetes

Functional foods as potential therapeutic options for metabolic syndrome

Low‐Dose Coconut Oil Supplementation Induces Hypothalamic Inflammation, Behavioral Dysfunction, and Metabolic Damage in Healthy Mice

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