2005
DOI: 10.1007/s11745-005-1360-x
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High‐fat diets impede the lowering effect of cyclosporine a on rat brain lipids and interact with the expression of apolipoproteins E and J

Abstract: Cyclosporine A (CsA), a common immunosuppressive agent, produces hyperlipidemia and apolipoprotein profile alterations in plasma as well as neurological and psychiatric complications. In rats, 10 mg CsA/kg/d treatments for 3 wk induce alterations of the electroencephalogram, and of the blood and brain lipids. Using this model, we evaluated whether triacylglycerol (TG)- and lecithin (PC)-enriched diets, reported to decrease epileptic episodes (TG) and to improve memory, could modify the effects of CsA treatment… Show more

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Cited by 3 publications
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“…So CsA may mediate lipid metabolism by down‐regulating the contents of TG in liver, inhibiting the clearance of cholesterol in blood, or both. Considering the wide pharmacological effects of CsA, it is necessary to eliminate the possibility that decreased hepatic TG accumulation was derived from secondary effects. We used the siRNA of CypD in vitro and gained consistent results, suggesting that CypD is a specific target for prevention and therapy of NAFLD.…”
Section: Discussionmentioning
confidence: 99%
“…So CsA may mediate lipid metabolism by down‐regulating the contents of TG in liver, inhibiting the clearance of cholesterol in blood, or both. Considering the wide pharmacological effects of CsA, it is necessary to eliminate the possibility that decreased hepatic TG accumulation was derived from secondary effects. We used the siRNA of CypD in vitro and gained consistent results, suggesting that CypD is a specific target for prevention and therapy of NAFLD.…”
Section: Discussionmentioning
confidence: 99%
“…These results suggest that CsA can be, to a certain degree, a potential therapeutic tool for hepatic mitochondrial stress. Considering the wide pharmacological effects of CsA as an immunosuppressant [65], it is necessary to eliminate the possibility that decreased hepatic mitochondrial stress was derived from secondary effects. The specific inhibition of CypD in vitro should be used to see whether there will be consistent results.…”
mentioning
confidence: 99%