2009
DOI: 10.1016/j.jhep.2008.08.025
|View full text |Cite
|
Sign up to set email alerts
|

High-fat nutrition reduces hepatic damage following exposure to bacterial DNA and hemorrhagic shock

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

1
7
0

Year Published

2010
2010
2024
2024

Publication Types

Select...
4
3
1

Relationship

3
5

Authors

Journals

citations
Cited by 14 publications
(8 citation statements)
references
References 32 publications
1
7
0
Order By: Relevance
“…29,30 Therefore, we investigated whether infusion of CCK resulting in physiologic plasma concentrations activates the nutritional anti-inflammatory pathway. Infusion of CCK8s in fasted rats, reaching arterial concentrations of 11 (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22) pM at shock and 20 (9 -25) pM at sacrifice, did not reduce systemic TNF-␣ (170 ͓113-230͔ pg/mL vs. vehicle: 178 ͓147-234͔ pg/mL) and IL-6 (196 ͓130 -204͔ pg/mL vs. vehicle: 198 ͓175-250͔ pg/mL). In addition, shock-induced leakage of HRP (2.9 ͓1.6 -4.0͔ g/mL vs. vehicle: 3.6 ͓2.6 -5.0͔ g/mL) and bacterial translocation (97 ͓60 -115͔ CFU/g tissue versus vehicle: 98 ͓90 -123͔ CFU/g tissue) remained unaltered after CCK8s infusion.…”
Section: Peripherally Acting Cck Triggers the Nutritional Anti-inflammentioning
confidence: 89%
See 2 more Smart Citations
“…29,30 Therefore, we investigated whether infusion of CCK resulting in physiologic plasma concentrations activates the nutritional anti-inflammatory pathway. Infusion of CCK8s in fasted rats, reaching arterial concentrations of 11 (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22) pM at shock and 20 (9 -25) pM at sacrifice, did not reduce systemic TNF-␣ (170 ͓113-230͔ pg/mL vs. vehicle: 178 ͓147-234͔ pg/mL) and IL-6 (196 ͓130 -204͔ pg/mL vs. vehicle: 198 ͓175-250͔ pg/mL). In addition, shock-induced leakage of HRP (2.9 ͓1.6 -4.0͔ g/mL vs. vehicle: 3.6 ͓2.6 -5.0͔ g/mL) and bacterial translocation (97 ͓60 -115͔ CFU/g tissue versus vehicle: 98 ͓90 -123͔ CFU/g tissue) remained unaltered after CCK8s infusion.…”
Section: Peripherally Acting Cck Triggers the Nutritional Anti-inflammentioning
confidence: 89%
“…53 Therefore, administration of lipid-rich nutrition appears to be a more physiologic and efficient intervention to activate the CCK/CCK-1 receptor mediated vagal anti-inflammatory pathway. In addition, enteral administration of lipid-rich nutrition has been demonstrated to inhibit inflammation and attenuate organ damage in several situations, such as hemorrhagic shock and postoperative ileus, [12][13][14][15] indicating that lipidrich enteral nutrition could be a safe and subtle intervention to attenuate inflammatory conditions in the clinical setting.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Cytokine release is subsequently inhibited through activation of nicotinic receptors on inflammatory cells through the vagus nerve (15-17). Also, several organs, including the intestine, were strongly protected after either pre-or posttreatment with lipid-rich nutrition (15,18,19).…”
mentioning
confidence: 99%
“…Moreover, lipid-rich feeding was demonstrated to decrease systemic cytokine release and preserve the gut barrier function 113,114 . Using a second hit model of hemorrhagic shock preceded by exposure to bacterial DNA, lipid-rich nutrition was shown to reduce liver injury 115 . Further investigations defined the vagal anti-inflammatory pathway as the major underlying mechanism of the anti-inflammatory nutritional effects.…”
Section: Nutritional Activation Of the Vagal Anti-inflammatory Pathwaymentioning
confidence: 99%