High Fetuin-A Level as a Protective Factor to Abdominal Aortic Calcification in Indonesian Regular Hemodialysis Patients

Muzasti, Riri Andri; Loesnihari, Ricke

doi:10.3889/oamjms.2019.167

Cited by 10 publications

(6 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Data from the Indonesian Renal Registry (2017) shows that hypertension is still the most common comorbid disease in CKD patients undergoing hemodialysis in Indonesia with (36%) and followed by diabetes (29%) [11]. This study is also consistent with study conducted by Muzasti et al in 2018 in Medan, Indonesia, where the majority of subjects who experienced CKD were men as many as 61.8% and also suffering from comorbid hypertension by 75% [12]. In line with this study, hypertension is the most common disease suffered by 51 respondents (71.8%) and DM in 13 respondents (18.3%).…”

Section: Discussionsupporting

confidence: 84%

Fibroblast Growth Factor-23 (FGF-23) in Patients with Regular Hemodialysis: A Risk Factor for Restless Legs Syndrome

Harahap

Muzasti

Nasution

2020

JETROMI

View full text Add to dashboard Cite

Background: Restless Legs Syndrome (RLS) is one of the most common sleep disturbance problems in dialysis patients. In this study, we would like to explore some of bone and mineral marker disorder especially fibroblast growth factor-23 (FGF-23)and its correlation with RLS in regular hemodialysis patients. Methods: This is a cross sectional study design involving 71 respondents with chronic kidney disease that already had regular hemodialysis at Haji Adam Malik Hospital Medan. Status of RLS in this patients were being evaluated according to the International Restless Leg Syndrome Study Group (IRLSG) by interviewing and laboratory examination of FGF-23, hemoglobin (Hb), serum iron (SI), total iron binding capacity (TIBC), transferrin saturation (TSAT), serum ferritin, calcium (Ca) and phosphate (P) level. Results: Of all study subjects, 26 respondents (34.6%) diagnosed with RLS. Bivariate analysis result showed that there is a relationship between FGF-23, hemoglobin, phosphate, and transferrin saturation level with RLS. Logistic regression analysis used to see the most dominant factor of all. Conclusion This study conclude that increase in FGF-23 levels can increase the risk of RLS. However, FGF-23 is not the most dominant risk factor for RLS in regular hemodialysis patients.

show abstract

Section: Discussionsupporting

confidence: 84%

Fibroblast Growth Factor-23 (FGF-23) in Patients with Regular Hemodialysis: A Risk Factor for Restless Legs Syndrome

Harahap

Muzasti

Nasution

2020

JETROMI

View full text Add to dashboard Cite

show abstract

“…Based on this, our study found that higher testosterone levels were bene cial in reducing AAC. Age is an important risk factor for vascular calci cation, and the risk of AAC increases with age [32][33][34]. In a further subgroup analysis, we also found that the protective effect of testosterone was more pronounced in older age groups (Age group = 63-79).…”

Section: Discussionsupporting

confidence: 62%

Ageing mediates the association between serum testosterone and severe abdominal aortic calcification

Lai,

Cao,

Zhang

et al. 2023

Preprint

View full text Add to dashboard Cite

BackgroundAbdominal aortic calcification (AAC) is acknowledged as a significant contributor to cardiovascular morbidity and mortality. However, the association between sex steroid hormones and the AAC is not well defined. PurposeOur study aims to investigate the previously unexplored link between serum sex steroid hormone levels and severe AAC within the National Health and Nutrition Examination Survey (NHANES) cohort, potentially shedding light on innovative treatment approaches. Methods The cross-sectional study utilized data from NHANES conducted between 2013-2014. A total of 1852 participants were included in the study. The severity of AAC was determined using the AAC 24-point scale, also known as the Kauppila calcification score. The serum sex steroid hormones assessed in this study included testosterone, estradiol, and sex hormone binding globulin (SHBG). These hormones were categorized into quintiles for subsequent analysis. Weighted multiple regression analyses were employed to investigate the potential relationship between serum sex steroid hormones and the occurrence of severe AAC. Additionally, subgroup and mediation analyses were conducted to ensure the robustness and validity of the findings. ResultsFor 1852 enrolled individuals, the prevalence of severe AAC stood at 8.00%. Serum sex steroid hormones levels were stratified into quintiles. The average values of testosterone by quintiles were 9.90 ng/dL, 19.45 ng/dL, 116.14 ng/dL, 338.21 ng/dL, and 558.86 ng/dL respectively. The averages of estradiol by quintiles were 3.45 pg/mL, 10.71 pg/mL, 19.63 pg/mL, 27.30 pg/mL, and 105.00 pg/mL respectively. The averages of SHBG by quintiles were 24.19 nmol/L, 37.49 nmol/L, 50.10 nmol/L, 67.49 nmol/L, and 117.34 nmol/L respectively. Analytical results from univariate and multivariate analysis suggested a link between higher levels of serum testosterone and a reduced incidence of severe AAC (odds ratio [OR] = 0.33, 95% confidence interval [CI] 0.13, 0.87, P = 0.0247 for quintile 5, P for trend = 0.025). A similar connection was observed with higher serum SHBG levels, which correlated with diminished severe AAC (OR = 0.47, 95% CI 0.23, 0.93, P = 0.0315 for quintile 5, P for trend = 0.034). Further subgroup analysis found that the inverse association between serum testosterone and severe AAC was more significant (OR = 0.32, 95% CI 0.11, 0.95, P = 0.0397 for quintile 4, OR = 0.22, 95% CI 0.07, 0.67, P = 0.0073 for quintile 5, P for trend = 0.010)in the older adults (age group = 63-79), and the negative association between serum SHBG and severe AAC was more stronger (OR = 0.26, 95% CI 0.11, 0.64, P = 0.0030 for quintile 4, OR = 0.31, 95% CI 0.11, 0.93, P = 0.0366 for quintile 5, P for trend = 0.028) in male. Finally, mediated analysis found that serum Klotho, a well-recognized anti-aging-related protein, may mediate the association between higher testosterone levels and decreased severe AAC. Conclusion This study highlights the potential negative association of serum testosterone with AAC, particularly among older individuals, and the effect may be exerted through Klotho.

show abstract

“…Different from Fetuin-A, which acts as a protective factor to abdominal aortic calcification, [ 24 ] the pathogenesis of correlation between FGF23 and abdominal aortic calcification was remained unclear. Vascular smooth muscle cells' (VSMC) transdifferentiation into osteoblast-like cells was an essential mechanism of vascular calcification.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of fibroblast growth factor 23 for abdominal aortic calcification in Indonesian hemodialysis patients

Muzasti

Lubis²

2021

Tzu Chi Medical Journal

View full text Add to dashboard Cite

Objective: Homeostasis of serum phosphorus and calcitriol level is regulated mainly by fibroblast growth factor 23 (FGF23). Studies show that elevated serum FGF23 level was significantly associated with aortic calcification severity, peripheral blood vessels, and a higher score of coronary artery calcification in patients undergoing hemodialysis. We did this cross-sectional study to determine the FGF23 diagnostic value for abdominal aortic calcification in Indonesian hemodialysis patients. Materials and Methods: This study included seventy-five, chronic hemodialysis patients. An enzyme-linked immunosorbent assay method was used to measure serum intact FGF23 level, and abdominal aortic calcification was detected by lateral lumbar X-ray. The diagnostic value of FGF23 was analyzed using receiver operating characteristic (ROC) curves. Results: fifty-one (68.0%) patients had abdominal aortic calcification (AAC). Serum intact FGF23 level ranged from 217 to 950 pg/mL with a median level of 328 pg/mL. The FGF23 levels in the serum of patients with AAC were significantly higher than those without AAC ( P < 0.001). The best cutoff point was 277 pg/mL. The calculated area under the ROC curves was 0.959 (95% confidence interval, 0.912–1.00); sensitivity was 94.0% and specificity was 84.0% ( P < 0.001). Conclusion: serum intact FGF23 level may be proposed as a proper tool for abdominal aortic calcification in Indonesian hemodialysis patients.

show abstract

High Fetuin-A Level as a Protective Factor to Abdominal Aortic Calcification in Indonesian Regular Hemodialysis Patients

Cited by 10 publications

References 12 publications

Fibroblast Growth Factor-23 (FGF-23) in Patients with Regular Hemodialysis: A Risk Factor for Restless Legs Syndrome

Fibroblast Growth Factor-23 (FGF-23) in Patients with Regular Hemodialysis: A Risk Factor for Restless Legs Syndrome

Ageing mediates the association between serum testosterone and severe abdominal aortic calcification

Diagnostic value of fibroblast growth factor 23 for abdominal aortic calcification in Indonesian hemodialysis patients

Contact Info

Product

Resources

About