High FIB-4 index as an independent risk factor of prevalent chronic kidney disease in patients with nonalcoholic fatty liver disease

Abstract

High noninvasive fibrosis score is associated with an increased risk of prevalent CKD; the FIB-4 is the better predictor. With a cut-off value of 1.100 for FIB-4, it is useful in excluding the presence of CKD in patients with NAFLD.

Non-alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases

“…Notably, in most of these studies the significant association between NAFLD and CKD persisted after adjustment for hypertension, T2DM and other known risk factors for CKD. Pan et al recently reported that after adjustment for visceral fat accumulation and other cardiometabolic risk factors, there was a positive, graded relationship between intrahepatic triglyceride content, as measured by magnetic resonance spectroscopy, and the presence of CKD or abnormal albuminuria in obese individuals 97. In a population-based study of 8270 Chinese adults with normal kidney function, NAFLD was independently associated with low levels of albuminuria also, defined as urine albumin/creatinine ratio below 30 mg/g 104.…”

Association Between Urinary Alpha1-Microglobulin Levels and Nonalcoholic Fatty Liver Disease: A Cross-Sectional Study

“…It has been demonstrated that the FIB-4 score based on several laboratory tests can reliably predict advanced fibrosis and cirrhosis in NAFLD [48]. Recently, Xu et al [49] reported that a high FIB-4 score (≥1.100) is associated with an increased risk of prevalent CKD (eGFR <60 mL/min/1.73 m 2 ) and is an independent predictor of CKD in individuals with ultrasonography-diagnosed NAFLD [49]. In our study, we have first reported that urinary A1M-creatinine ratio is positively associated with the FIB-4 score and is an independent factor predicting advanced fibrosis (FIB-4 ≥1.3) in NAFLD patients with normal-range eGFR.…”

Non-alcoholic fatty liver disease: an emerging driving force in chronic kidney disease

“…In the last 5 years, a number of cross-sectional community-based and hospital-based studies have consistently demonstrated that NAFLD, as diagnosed either by imaging [16][17][18][19][20][21][22][23][24] or by histology [25][26][27][28][29] , is associated with an increased prevalence of CKD (defined as presence of decreased estimated glomerular filtration rate [eGFR] or abnormal albuminuria or overt proteinuria) in patients with NAFLD. In these studies, the prevalence of CKD in patients with NAFLD ranged from approximately 20% to 55% compared to 5%-30% in those without NAFLD [16][17][18][19][20][21][22][23][24][25][26][27][28][29] .…”

“…In these studies, the prevalence of CKD in patients with NAFLD ranged from approximately 20% to 55% compared to 5%-30% in those without NAFLD [16][17][18][19][20][21][22][23][24][25][26][27][28][29] . Notably, in most of these studies the association between NAFLD and CKD was independent of common cardio-renal risk factors across a wide range of patient populations.…”