High fibre supplementation in patients with irritable bowel syndrome(IBS). Comparison between diet and partially hydrolysed guar-gum(PHGG) fibre treatment in an multicenter randomised trial

Treatment Effects of Partially Hydrolyzed Guar Gum on Symptoms and Quality of Life of Patients with Irritable Bowel Syndrome. A Multicenter Randomized Open Trial

“…In summary, a previous investigation (11) showed that PHGG was as effective as high-fiber supplementation in significantly reducing IBS symptoms but was better tolerated by patients and easier to administer than fiber. The present study showed that PHGG produces beneficial effects over short periods (1-month admistration) in improving core IBS symptoms and psychological aspects related to IBS.…”

“…Our previous findings in an open trial (11) showed that PHGG was as effective as high-fiber diet supplementation in improving core IBS symptoms such as abdominal pain and bowel habit, regardless of the bowel pattern (constipation-or diarrhea-predominant). Since the study was designed as an open trial, patients were allowed to cross over from one treatment group to the other on the basis of their preference and their judgment over the course of dietary intervention and symptom relief.…”

“…PHGG has proved effective in softening and improving the output of feces and increasing bulking capacities (fecal weight, frequency of defecation, and fecal excretory feeling) (8)(9)(10). In a previous investigation (11), 188 IBS patients were treated with high-fiber diet supplementation (30 g/day of wheat bran) or PHGG (5 g/day) for 12 weeks. Improvements in core IBS symptoms (abdominal pain and bowel habits) were observed with both bran and PHGG, but the latter was better tolerated and preferred by patients.…”

Update S3-Leitlinie Reizdarmsyndrom: Definition, Pathophysiologie, Diagnostik und Therapie. Gemeinsame Leitlinie der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) und der Deutschen Gesellschaft für Neurogastroenterologie und Motilität (DGNM) – Juni 2021 – AWMF-Registriernummer: 021/016

“…In einer kontrollierten, randomisierten Studie wurden 30 g Weizenkleie pro Tag mit 5 g partiell hydrolisiertem Guar Gum verglichen. Symptomerleichterung und Verträglichkeit waren besser unter Guar Gum 520 . Eine neue Metaanalyse aus dem Jahr 2015 zeigte eine deutliche Symptombesserung und Verringerung des abdominellen Schmerzes unter Einnahme von löslichen Ballaststoffen.…”

Aktualisierte S2k-Leitlinie chronische Obstipation der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) und der Deutschen Gesellschaft für Neurogastroenterologie & Motilität (DGNM) – April 2022 – AWMF-Registriernummer: 021–019

“…Nur für Reizdarmpatienten wurde nachgewiesen, dass die löslichen Ballaststoffe besser verträglich sind als die natürlichen. Für die Obstipations-Patienten fehlt ein solcher Nachweis 179 180 .…”