High-Field (9.4T) Magnetic Resonance Imaging in Squirrel Monkey

Nelson, Aimee J.; Cheney, Cheryl A.; Chen, Yin-Ching Iris; Dai, Guangping; Marini, Robert P.; Grindlay, Graham; Ishizawa, Yumiko; Moore, Christopher I.

doi:10.1007/978-0-387-38607-2_16

Cited by 5 publications

(7 citation statements)

References 85 publications

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“…The probe was indented approximately 0.5mm before the onset of vibration. This stimulus evokes robust, reliable activation in the postcentral gyrus of monkeys20 and humans 19, 21…”

Section: Methodsmentioning

confidence: 97%

Digit‐specific aberrations in the primary somatosensory cortex in Writer's cramp

Nelson

Blake

Chen

2009

Annals of Neurology

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112

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“…The probe was indented approximately 0.5mm before the onset of vibration. This stimulus evokes robust, reliable activation in the postcentral gyrus of monkeys20 and humans 19, 21…”

Section: Methodsmentioning

confidence: 97%

Digit‐specific aberrations in the primary somatosensory cortex in Writer's cramp

Nelson

Blake

Chen

2009

Annals of Neurology

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112

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“…Statistical maps for gradient-echo echo planar imaging (EPI) functional data were generated using AFNI (Cox, 1996; Nelson et al, 2006) (NIH, http://afni.nimh.nih.gov/afni, Bethesda, MD) and MATLAB (The Mathworks, Natick, MA). EPI functional data were first motion corrected in all three spatial dimensions without spatial smoothing or undistortion to preserve maximal resolution.…”

Section: Methodsmentioning

confidence: 99%

Young adult born neurons enhance hippocampal dependent performance via influences on bilateral networks

Zhuo

Tseng

Desai

et al. 2016

eLife

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Adult neurogenesis supports performance in many hippocampal dependent tasks. Considering the small number of adult-born neurons generated at any given time, it is surprising that this sparse population of cells can substantially influence behavior. Recent studies have demonstrated that heightened excitability and plasticity may be critical for the contribution of young adult-born cells for certain tasks. What is not well understood is how these unique biophysical and synaptic properties may translate to networks that support behavioral function. Here we employed a location discrimination task in mice while using optogenetics to transiently silence adult-born neurons at different ages. We discovered that adult-born neurons promote location discrimination during early stages of development but only if they undergo maturation during task acquisition. Silencing of young adult-born neurons also produced changes extending to the contralateral hippocampus, detectable by both electrophysiology and fMRI measurements, suggesting young neurons may modulate location discrimination through influences on bilateral hippocampal networks.DOI: http://dx.doi.org/10.7554/eLife.22429.001

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“…1A. Boxcar correlation maps for EPI functional data were generated using AFNI (Cox 1996;Nelson et al 2006) (National Institutes of Health, http://afni.nimh.nih.gov/afni, Bethesda, MD) and MAT-LAB (The Mathworks, Natick, MA). EPI functional data were motion corrected in all three spatial dimensions, but no spatial smoothing or undistortion was performed (to preserve full resolution).…”

Section: Opto-fmri Of Mouse: Data Analysismentioning

confidence: 99%

“…1A, top right), delayed by one repetition time (T R ; 2.5 s) to compensate for the BOLD response time lag (Cox 1996;Nelson et al 2006); we label this analysis "boxcar correlation" in the text. Activation in a region was deemed significant if a cluster (here used in the fMRI sense of the word) of at least six contiguous voxels had correlation P values at an uncorrected threshold of P Ͻ 0.005.…”

Section: Opto-fmri Of Mouse: Data Analysismentioning

confidence: 99%

Mapping brain networks in awake mice using combined optical neural control and fMRI

Desai

Kahn

Knoblich

et al. 2011

Journal of Neurophysiology

257

241

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Mapping brain networks in awake mice using combined optical neural control and fMRI. J Neurophysiol 105: 1393-1405, 2011. First published December 15, 2010 doi:10.1152/jn.00828.2010. Behaviors and brain disorders involve neural circuits that are widely distributed in the brain. The ability to map the functional connectivity of distributed circuits, and to assess how this connectivity evolves over time, will be facilitated by methods for characterizing the network impact of activating a specific subcircuit, cell type, or projection pathway. We describe here an approach using high-resolution blood oxygenation level-dependent (BOLD) functional MRI (fMRI) of the awake mouse brain-to measure the distributed BOLD response evoked by optical activation of a local, defined cell class expressing the light-gated ion channel channelrhodopsin-2 (ChR2). The utility of this opto-fMRI approach was explored by identifying known cortical and subcortical targets of pyramidal cells of the primary somatosensory cortex (SI) and by analyzing how the set of regions recruited by optogenetically driven SI activity differs between the awake and anesthetized states. Results showed positive BOLD responses in a distributed network that included secondary somatosensory cortex (SII), primary motor cortex (MI), caudoputamen (CP), and contralateral SI (c-SI). Measures in awake compared with anesthetized mice (0.7% isoflurane) showed significantly increased BOLD response in the local region (SI) and indirectly stimulated regions (SII, MI, CP, and c-SI), as well as increased BOLD signal temporal correlations between pairs of regions. These collective results suggest opto-fMRI can provide a controlled means for characterizing the distributed network downstream of a defined cell class in the awake brain. Opto-fMRI may find use in examining causal links between defined circuit elements in diverse behaviors and pathologies.Functional MRI (fMRI) based on the blood oxygenation leveldependent (BOLD) signal (Kwong et al. 1992;Ogawa et al. 1990Ogawa et al. , 1992) is widely used to indirectly measure neural activity in distributed brain networks in humans and nonhuman primates. A recent study has shown that optogenetic strategies, using activation of channelrhodopsin-2 (ChR2)-expressing neurons (Boyden et al. 2005), can be used with high-field MRI imaging to evoke BOLD signals in the anesthetized rodent (Lee et al. 2010). We present data obtained using optogenetic activation of a specific cell class in the awake animal, mapping and characterizing the distributed network responses that result. These opto-fMRI studies collectively open up a wide array of opportunities for exploring the relation between BOLD responses and neural activity and to use rodent models to assess the impact of causal manipulations on distributed brain networks.The recent paper of Lee et al. (2010) These results raise the possibility that opto-fMRI could serve as a tool to explore properties of distributed brain networksfor example, enabling researchers to focus their electrophysiolo...

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High-Field (9.4T) Magnetic Resonance Imaging in Squirrel Monkey

Cited by 5 publications

References 85 publications

Digit‐specific aberrations in the primary somatosensory cortex in Writer's cramp

Digit‐specific aberrations in the primary somatosensory cortex in Writer's cramp

Young adult born neurons enhance hippocampal dependent performance via influences on bilateral networks

Mapping brain networks in awake mice using combined optical neural control and fMRI

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