2021
DOI: 10.1016/j.forsciint.2021.110718
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High-field and benchtop NMR spectroscopy for the characterization of new psychoactive substances

Abstract: New psychoactive substances (NPS) have become a serious threat for public health in Europe due to their ability to be sold in the street or on the darknet. Regulating NPS is an urgent priority but comes with a number of analytical challenges since they are structurally close to legal products. A number of analytical techniques can be used for identifying NPS, among which NMR spectroscopy is in the limelight. High field NMR is typically used for structural elucidation in combination with others techniques like … Show more

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Cited by 26 publications
(19 citation statements)
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“…High‐field NMR is a powerful technique that has been underutilized in drug analysis (Hussain et al, 2020; Serrano et al, 2020) but it seem to be drawing more interest of the forensic community in the analysis of NPS, especially when no reference material is available for comparison. This technique provides unequivocal structure determination (Castaing‐Cordier et al, 2021; Serrano et al, 2020) and it can be performed using different modes such as one‐dimensional proton ( 1 H) and carbon ( 13 C) NMR and two‐dimensional correlation NMR (e.g., homonuclear correlation spectroscopy [COSY], nuclear overhauser effect spectroscopy [NOESY], and HMQC) (Bono, 2007; UNODC, 2020b). Fast analyses, high reproducibility, and minimal low sample preparation are some of the analytical advantages offered by NMR (Santos et al, 2018; Serrano et al, 2020), without requiring any prior separation (Ribeiro et al, 2018).…”
Section: Nuclear Magnetic Ressonancementioning
confidence: 99%
“…High‐field NMR is a powerful technique that has been underutilized in drug analysis (Hussain et al, 2020; Serrano et al, 2020) but it seem to be drawing more interest of the forensic community in the analysis of NPS, especially when no reference material is available for comparison. This technique provides unequivocal structure determination (Castaing‐Cordier et al, 2021; Serrano et al, 2020) and it can be performed using different modes such as one‐dimensional proton ( 1 H) and carbon ( 13 C) NMR and two‐dimensional correlation NMR (e.g., homonuclear correlation spectroscopy [COSY], nuclear overhauser effect spectroscopy [NOESY], and HMQC) (Bono, 2007; UNODC, 2020b). Fast analyses, high reproducibility, and minimal low sample preparation are some of the analytical advantages offered by NMR (Santos et al, 2018; Serrano et al, 2020), without requiring any prior separation (Ribeiro et al, 2018).…”
Section: Nuclear Magnetic Ressonancementioning
confidence: 99%
“…A sequences for experiments of solubility of glyburide were carried out utilizing G1, G2 and G3 dendrimers which have terminal hydroxyl groups found OH8, OH32 and OH128 respectively. In the presence of the full generation dendrimer the solubility of glyburide linearly increased with the increase in the concentrations of the dendrimer which may be due to the terminal hydroxyl groups which may attach with glyburide drug molecules [41,42].…”
Section: Effects Of Dendrimers Concentration On Solubility Of Glyburidementioning
confidence: 99%
“…Forensic drug analysis is one of the most anticipated applications of benchtop NMR spectroscopy, and many related studies have already been conducted (Table 2). In these cases, the benchtop NMR spectra of drugs are most often compared with the related high-field NMR spectra in a library, as high-field NMR spectroscopy has been extensively applied in forensic drug analysis, especially to characterize addictive, toxic, fraud, and fake drugs [35,36]. Furthermore, studies have been conducted on the screening of various drugs such as smokable herbal mixtures (known to have the same effects as cannabis) [37] and derivatives of morphine, amphetamine, and ketamine [38].…”
Section: Pharmaceuticals and Drugsmentioning
confidence: 99%