High‐Flexibility, High‐Toughness Double‐Cross‐Linked Chitin Hydrogels by Sequential Chemical and Physical Cross‐Linkings

Xu, Didi; Huang, Junchao; Zhao, Dan; Ding, Beibei; Zhang, Lina; Cai, Jie

doi:10.1002/adma.201600448

Cited by 261 publications

(172 citation statements)

References 38 publications

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“…[18c,19a] Therefore, homogeneously modified chitin derivatives have been scarcely reported for use as the antimicrobial reagents . Recently, a previously reported aqueous KOH/urea solution, which dissolves α‐chitin extracted from lobster and crab shells within several minutes, has been exploited as a high‐efficiency, energy‐saving, and “green” route to produce tough and transparent chitin films and double‐crosslinked hydrogels . This aqueous KOH/urea solution is a more sustainable alternative to strong or highly polar solvents, saturated CaCl 2 ·2H 2 O/methanol, ionic liquids, and deep eutectic solvents, especially for the large‐scale production and biomedical applications of the chitin derivatives .…”

Section: Antimicrobial and Hemolytic Activities Of Quaternized β‐Chitmentioning

confidence: 99%

Green Fabrication of Amphiphilic Quaternized β‐Chitin Derivatives with Excellent Biocompatibility and Antibacterial Activities for Wound Healing

et al. 2018

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Bacterial infection has always been a great threat to public health, and new antimicrobials to combat it are urgently needed. Here, a series of quaternized β-chitin derivatives is prepared simply and homogeneously in an aqueous KOH/urea solution, which is a high-efficiency, energy-saving, and "green" route for the modification of chitin. The mild reaction conditions keep the acetamido groups of β-chitin intact and introduce quaternary ammonium groups on the primary hydroxyl at the C-6 position of the chitin backbone, allowing the quaternized β-chitin derivatives (QCs) to easily form micelles. These QCs are found to exhibit excellent antimicrobial activities against Escherichia coli, Staphylococcus aureus, Candida albicans, and Rhizopus oryzae with minimum inhibitory concentrations (MICs) of 8, 12, 60, and 40 µg mL , respectively. As a specific highlight, their inherent outstanding biocompatibility and significant accelerating effects on the healing of uninfected, E. coli-infected, and S. aureus-infected wounds imply that these novel polysaccharide-based materials can be used as dressings for clinical skin regeneration, particularly for infected wounds.

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Section: Antimicrobial and Hemolytic Activities Of Quaternized β‐Chitmentioning

confidence: 99%

Green Fabrication of Amphiphilic Quaternized β‐Chitin Derivatives with Excellent Biocompatibility and Antibacterial Activities for Wound Healing

et al. 2018

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“…The reversible crosslinks and structures can dissociate to absorb energy via gel deformation and reform when the stress is removed, and the covalent crosslinks distribute the stress throughout the network and maintain the gel shape to ensure recovery of the original state upon unloading. Following these guidelines, various types of hydrogels with extraordinary mechanical properties have been produced, including topological gels, slide‐ring gels, double‐network gels, and double‐crosslinked gels . However, most of these hydrogels require synthetic polymers (e.g., polyacrylamide, polyethylene glycol, and polyampholytes) as their main scaffold.…”

Section: Introductionmentioning

confidence: 99%

“…Alternatively, a few natural polymer‐based tough hydrogels have been produced using polysaccharides and recombinant peptides with the aim of addressing the biocompatibility issue. Cai's and co‐workers dissolved chitin and cellulose in KOH/urea and LiOH/urea solution, respectively, chemically crosslinked the polymers with epichlorohydrin and immersed the hydrogel in an ethanol solution to introduce hydrophobic crosslinks and crystallite regions . The obtained hydrogels stretched over 80% with an elastic modulus of 0.1–5 MPa.…”

Section: Introductionmentioning

confidence: 99%

Hofmeister Effect‐Assisted One Step Fabrication of Ductile and Strong Gelatin Hydrogels

Huang

Wang

2017

Adv Funct Materials

349

271

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Hydrogels with high strength and ductility are normally prepared from synthetic polymers, and most protein-based hydrogels are soft and brittle. Here, a strong, ductile gelatin hydrogel is prepared by simply soaking a virgin gelatin gel in an ammonium sulfate solution. The polymer chains in the covalent, crosslink-free network can freely move to homogeneously distribute stress, and more importantly, the highly kosmotropic ammonium sulfate ions greatly enhance the hydrophobic interactions and chain bundling within the gelatin gels. As a result, the treated hydrogels have an extraordinary ultimate strength (compressive and tensile strains of over 99% and 500%, respectively, and stresses of 12 and 3 MPa) superior to that of common protein gels. The physical crosslinks introduced by the Hofmeister effect can rapidly absorb energy and sustain large deformations via decrosslinking and dissociation, which result in energy dissipation and antifatigue properties. The effects of the gelatin and (NH 4 ) 2 SO 4 concentrations on the hydrogel mechanics are evaluated, and the possible strengthening mechanism is discussed. The effect of various ions in the Hofmeister series on the gelatin hydrogel is also investigated. Kosmotropic ions enhance the mechanical properties, whereas chaotropic ions soften and dissolve the gel.

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“…Cellulose Nanocrystal (CNC) has abundant reactive –OH groups that can be grafted with polyacrylic acid (PAA), which is a material with excellent swelling capacities 37 . Owing to three-dimensional networks of hydrogels by physical or chemical cross-links 38 , cellulose-based hydrogels can absorb large quantities of water in short time 39 and maintain water-saturated state. Due to these attractive structural properties, cellulose-based hydrogels are considered as the carrier to fabricate Eu 2+ /Dy 3+ doped SrAl 2 O 4 materials.…”

Section: Introductionmentioning

confidence: 99%

A green route to prepare fluorescent and absorbent nano-hybrid hydrogel for water detection

Wang

Qing

Yan

et al. 2017

Sci Rep

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An environment-friendly fluorescent nano-hybrid hydrogel has been synthesized successfully, from cellulose nanocrystal (CNC), acrylic acid (AA) and phosphorescent Eu2+/Dy3+ doped SrAl2O4 via free radical polymerization. The hydrogel network matrix fixed Eu2+/Dy3+ doped SrAl2O4 nanoparticles by polymer chains with coordinate bonds that prevented particles from aggregating and quenching in water. The fluorescent nano-hybrid hydrogel exhibited extremely high water absorption of which the swelling ratio in distilled water and NaCl salt solution were respectively of 323.35 g/g and 32.65 g/g. Furthermore, the hydrogel displayed excellent water retention property that can keep half of the moisture even exposed to 80 °C for 210 min. Besides, the hydrogel had bright green fluorescence under the sunlight or ultraviolet excitation, and the fluorescence intensity was up to 125477 after swelling 50 times in water. The time-resolved photoluminescence (TRPL) afterglow decay examination showed that the fluorescent emission persisted for 4 h after hydrogels excited at 368 nm wavelength UV-light for 10 min. The fluorescence intensity behaved significant linear relationship with the swelling ratio. As a result, these hydrogels were considered as promising candidates for the preparation of stable and sensitive sensor materials in green water detection.

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High‐Flexibility, High‐Toughness Double‐Cross‐Linked Chitin Hydrogels by Sequential Chemical and Physical Cross‐Linkings

Cited by 261 publications

References 38 publications

Green Fabrication of Amphiphilic Quaternized β‐Chitin Derivatives with Excellent Biocompatibility and Antibacterial Activities for Wound Healing

Green Fabrication of Amphiphilic Quaternized β‐Chitin Derivatives with Excellent Biocompatibility and Antibacterial Activities for Wound Healing

Hofmeister Effect‐Assisted One Step Fabrication of Ductile and Strong Gelatin Hydrogels

A green route to prepare fluorescent and absorbent nano-hybrid hydrogel for water detection

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