High flow nasal heliox improves work of breathing and attenuates lung injury in a newborn porcine lung injury model

Jassar, Romal; Vellanki, Haritha; Zhu, Yan; Hesek, Anne; Wang, Jordan V; Rodrı́guez, E.; Wolfson, Marla R.; Shaffer, Thomas H.

doi:10.3233/npm-15915039

Cited by 3 publications

(1 citation statement)

References 33 publications

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“…The main cause of MAS is fetal excretion of meconium polluting amniotic fluid, followed by inhalation of meconium into the respiratory tract causing mechanical obstruction, which narrows the airway and increases resistance. Helium, which has a low density and high viscosity and mobility due to its physical properties contributing to smaller resistance, is useful in the treatment of MAS to significantly increase ventilation per minute and the expiratory flow, reduce power consumption due to breathing, accelerate the dispersion of oxygen and CO 2 , and improve lung compliance 28–32 . SIMV produces more synchronization and fewer cardiovascular complications in the treatment of MAS 33,34 .…”

Section: Discussionmentioning

confidence: 99%

A randomized single‐center controlled trial of synchronized intermittent mandatory ventilation with heliox in newborn infants with meconium aspiration syndrome

Tang²,

Shen

et al. 2021

Pediatric Pulmonology

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Objective This study aimed to investigate the beneficial effects of synchronized intermittent mandatory ventilation (SIMV) with heliox in newborn infants with meconium aspiration syndrome (MAS). Methods Seventy‐one newborn infants with MAS in the neonatal intensive care unit (NICU) of Daping Hospital of Army Medical University were enrolled in the trial. Infants treated with SIMV were randomized and divided into the heliox group (n = 35) and control group (n = 36). The heliox group received heliox for 6 h followed by air‐oxygen mixed gas, and the control group received air‐oxygen mixed gas. The primary outcome measures were PaO2/FiO2 (P/F) and the extubation time. The secondary outcome measures were the incidence of mechanical ventilation complications, hospital length of stay in the NICU, blood gas analysis, and inflammation markers. Results The P/F in the heliox group was significantly better than that in the control group (p < .001). The extubation time and hospital length of stay in the NICU in the heliox group were shorter than those in the control group (p < .001). The inflammation markers at 6 h and myocardial injury markers at 24 h were decreased compared with those at 0 h, and those in the heliox group were more significantly decreased than those in the control group ([interleukin {IL}‐6/IL‐8/tumor necrosis factor α] p < .001, [C‐reaction protein] p = .012; [creatine kinase] p < .001, [CK‐MB] p = .041). Conclusion Heliox appears to be more effective in reducing the length of ventilation and increasing carbon dioxide eliminations than an air‐oxygen mixture in infants with MAS under the support of SIMV.

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Section: Discussionmentioning

confidence: 99%

A randomized single‐center controlled trial of synchronized intermittent mandatory ventilation with heliox in newborn infants with meconium aspiration syndrome

Tang²,

Shen

et al. 2021

Pediatric Pulmonology

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High Flow Nasal Oxygen: From Physiology to Clinical Practice

Einav

Antonini

2022

Mechanical Ventilation From Pathophysiology to Clinical Evidence

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The impact of different gas mixtures on inflammatory responses in advanced recreational divers

et al. 2021

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Introduction: Decompression sickness (DCS) is considered a ‘bubble disease’. Intravascular bubbles activate inflammatory responses associated with endothelial dysfunction. Breathing gas has been proposed as a potential risk factor but this is inadequately studied. Different gases are used in scuba diving. Helium-containing 'trimix' could theoretically mitigate inflammation and therefore reduce DCS risk. This study determined the effect of air and trimix on the inflammatory response following dives to 50 metres of sea water, and evaluated the differences between them in advanced recreational divers. Methods: Thirty-three divers were enrolled in this observational study and were divided in two groups: 17 subjects were included in the air group, and 16 different subjects were included in the trimix (21% oxygen, 35% helium, 44% nitrogen) group. Each subject conducted a single dive, and both groups used a similar diving profile of identical duration. A venous blood sample was taken 30 min before diving and 2 h after surfacing to evaluate changes in interleukins (IL) IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, tumour necrosis factor α (TNFα), vascular endothelial growth factor (VEGF), Interferon γ (IFN-γ), monocyte chemoattractant protein 1 (MCP-1) and epithelial growth factor (EGF) after diving. Results: No differences were observed between groups in demographic data or diving experience. Following the dive, IL-6 values showed a slight increase, while IL-8 and EGF decreased in both groups, without significant variation between the groups. Conclusions: In physically fit divers, trimix and air gas mixture during deep diving did not cause relevant changes in the inflammatory markers tested.

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High flow nasal heliox improves work of breathing and attenuates lung injury in a newborn porcine lung injury model

Abstract: High flow nasal Heliox decreased respiratory load, reduced resistive work of breathing indices and attenuated lung inflammatory profile while ventilation was supported at less pressure effort in the presence of acute lung injury.

Cited by 3 publications

References 33 publications

A randomized single‐center controlled trial of synchronized intermittent mandatory ventilation with heliox in newborn infants with meconium aspiration syndrome

A randomized single‐center controlled trial of synchronized intermittent mandatory ventilation with heliox in newborn infants with meconium aspiration syndrome

High Flow Nasal Oxygen: From Physiology to Clinical Practice

The impact of different gas mixtures on inflammatory responses in advanced recreational divers

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