2018
DOI: 10.4103/ejcdt.ejcdt_33_18
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High-flow nasal oxygen therapy versus noninvasive ventilation in chronic interstitial lung disease patients with acute respiratory failure

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Cited by 15 publications
(16 citation statements)
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“…Intubation AHRF (immunocompromised patients [100%]) HFNC: 64 [55–70] a COT: 63 [56–71] a HFNC: 136 [96–187] a COT: 128 [92–164] a Doshi 2018 [ 57 ] 228 NPPV HFNC 1. Intubation AHRF (COPD exacerbation [26.0%]) NPPV: 63 (15) HFNC: 63 (14) NA Eman 2018 [ 48 ] 70 NPPV HFNC 1. Mortality (in-hospital) 2.…”
Section: Resultsmentioning
confidence: 99%
“…Intubation AHRF (immunocompromised patients [100%]) HFNC: 64 [55–70] a COT: 63 [56–71] a HFNC: 136 [96–187] a COT: 128 [92–164] a Doshi 2018 [ 57 ] 228 NPPV HFNC 1. Intubation AHRF (COPD exacerbation [26.0%]) NPPV: 63 (15) HFNC: 63 (14) NA Eman 2018 [ 48 ] 70 NPPV HFNC 1. Mortality (in-hospital) 2.…”
Section: Resultsmentioning
confidence: 99%
“…We identified 5 parallel-group RCTs (33,(64)(65)(66)(67) and 2 crossover RCTs (68,69) comparing HFNC to NIV in AHRF. Three RCTs reported short-term mortality (hospital, ICU, or 28day), finding that HFNC may reduce mortality (RR 0.77, 95%CI 0.52 to 1.14; RD -4.5%, 95%CI -9.4 to 2.7; very low certainty); however, this is limited by imprecise and inconsistent effects between the studies.…”
Section: Evidence Summarymentioning
confidence: 99%
“…5 RCTs evaluated effect of HFNC on intubation, demonstrating that HFNC may reduce intubation (RR 0.84, 95% CI 0.61 to 1.16; RD -4.1%, -10.1 to 4.1; low certainty), but this result is limited by indirectness and imprecision. (33,(64)(65)(66)(67) HFNC may have a small impact on length of stay, potentially decreasing ICU stay by 0.55 days (95% CI -2.0 to 0.89, low certainty) and increasing overall hospital stay by 0.8 days (95% CI -0.59 to 2.19, very low certainty). Pooled analysis of 4 RCTs shows that HFNC may improve patient comfort (SMD -0.23, 95% CI -0.55 to 0.09, moderate certainty) but results in greater degree of perceived dyspnea than NIV (SMD 0.19, 95% CI -0.01 to 0.40, very low certainty).…”
Section: Evidence Summarymentioning
confidence: 99%
“…396,397,[401][402][403][404][405][406][407][408][409][410][411][412] When compared to NHFT, NIV yielded an RD of 8 fewer per 1,000 (95%CI: 35 fewer to 25 more) (3 RCTs, n = 338). 396,397,413 The estimate of network effects for tracheal intubation were as follows: when compared to COT, NHFT yielded an RD of 65 fewer per 1,000 (95%CI: 95 fewer to 28 fewer) (6 RCTs, n = 1,563) [396][397][398][399][400]404 and NIV yielded an RD of 60 fewer per 1,000 (95% CI: 92 fewer to 29 fewer) (17 RCTs, n = 2,506. 396,397,[401][402][403][405][406][407][408][409][410][411][414][415][416][417][418] When compared to NHFT, NIV yielded an RD of 5 more per 1,000 (95%CI: 32 fewer to 46 more) (5 RCTs, n = 1,584).…”
Section: Rationalementioning
confidence: 99%