In recent years, operation of wide band-gap semiconductor detectors under high-flux irradiation in medical and security applications has called the attention of the scientific commnity. 1, 2 However, under high-flux irradiation, these detectors are limited by poor hole transport properties 2 and other factors. In our studies, the build up of space charge as a function of time has been systematically investigated through direct comparison between experiments and charge transport simulations. In order to benchmark and calibrate our simulations, 3 charge transport properties of CdZnTe detectors used in high-flux experiments were measured. Our results show that the polarization effect, caused by the build up of positive space charge as a function of time, initially distorts and eventually causes complete breakdown of the operating electric field.