High Frequency of Antibody Response to Plasmodium falciparum Gametocyte Antigens during Acute Malaria Infections in Papua New Guinea Highlanders

Graves, Patricia M.; Doubrovsky, Anna; Carter, R; Eida, S; Beckers, Pascal

doi:10.4269/ajtmh.1990.42.515

Cited by 19 publications

(17 citation statements)

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“…Despite the rapid induction of these sexual stage specific response, prevalences of anti-Pfs48/45 and antiPfs230 antibodies are generally low in semi-immune populations when compared to antibodies to asexual stage antigens. Although an effect of cumulative malaria exposure on sexual stage immunity was observed in PNG [81], other studies contradict this as an important influence. If cumulative exposure…”

Section: Antibodies To Pfs48/45 and Pfs230 And Transmission Reducing mentioning

confidence: 78%

“…Almost all these results are obtained with sera from gametocyte carriers. The few studies that compared infected and uninfected individuals show that the seroprevalence in the uninfected population is much lower for both Pfs48/45 and Pfs230 [80][81][82]. This suggests that the half life of these antibodies is relatively short in the absence of circulating gametocytes.…”

Section: Antibodies To Pfs48/45 and Pfs230 And Transmission Reducing mentioning

confidence: 90%

“…Antibodies against Pfs48/45 and Pfs230 are acquired after one or few infections [81][82][83]. Despite the rapid induction of these sexual stage specific response, prevalences of anti-Pfs48/45 and antiPfs230 antibodies are generally low in semi-immune populations when compared to antibodies to asexual stage antigens.…”

Section: Antibodies To Pfs48/45 and Pfs230 And Transmission Reducing mentioning

confidence: 96%

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Sexual-Stage Antibody Responses to P. falciparum in Endemic Populations

Bousema¹,

Drakeley²,

Sauerwein

2006

CMM

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Gametocytes and sporogonic stages are responsible for the spread of disease and drug resistance in the population. Sexual stage immunity affects the infectiousness of gametocytes to mosquitoes. Specific antibodies including anti-Pfs48/45 and anti-Pfs230 antibodies are found in individuals with limited prior exposure to malaria. Sexual stage antibodies are rapidly acquired after infection and are relatively prevalent in gametocytaemic individuals. Functional transmission reducing activity (TRA) is found after primary infections and in young children and appears to depend on recent rather than cumulative exposure to gametocytes. Exposure to gametocytes decreases with age most likely as a consequence of the acquisition of asexual-stage immunity that controls asexual parasite density and consequently gametocytaemia. This results in lower exposure to the antigenic load of gametocytes in semi-immune individuals. Since sexual stage immunity is probably short-lived in the absence of gametocytes, we hypothesize that sexual stage immunity will wane, resulting in low antibody and TRA prevalences in clinically semi-immune carriers.

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Section: Antibodies To Pfs48/45 and Pfs230 And Transmission Reducing mentioning

confidence: 78%

Section: Antibodies To Pfs48/45 and Pfs230 And Transmission Reducing mentioning

confidence: 90%

Section: Antibodies To Pfs48/45 and Pfs230 And Transmission Reducing mentioning

confidence: 96%

See 1 more Smart Citation

Sexual-Stage Antibody Responses to P. falciparum in Endemic Populations

Bousema¹,

Drakeley²,

Sauerwein

2006

CMM

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“…Since age-related cumulative exposure seems to have little effect on sexual stage immune responses, we speculate that the greater prevalence in young children may reflect the initial immune response to gametocytes, as was observed in individuals after a single or limited number of exposures to infection with either P. falciparum (6,22,33) or Plasmodium vivax (31). The remarkable nadir in both Pfs48/45 and Pfs230 seroprevalences in children aged 5 to 9 years old was previously observed in populations exposed to endemic malaria.…”

Section: Discussionmentioning

confidence: 99%

“…Both antigens are on the surface of the gametocyte and were expected to have shown similar patterns of immune response. The difference observed in their immune responses may be dependent on the difference in their immunogenicities, with Pfs230 being more immunogenic than Pfs48/45 (22).…”

Section: Entomologymentioning

confidence: 99%

Naturally Acquired Immune Responses to Plasmodium falciparum Sexual Stage Antigens Pfs48/45 and Pfs230 in an Area of Seasonal Transmission

et al. 2011

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Acquisition of immunity to Plasmodium falciparum sexual stages is a key determinant for reducing humanmosquito transmission by preventing the fertilization and the development of the parasite in the mosquito midgut. Naturally acquired immunity against sexual stages may therefore form the basis for the development of transmission-blocking vaccines, but studies conducted to date offer little in the way of consistent findings. Here, we describe the acquisition of antigametocyte immune responses in malaria-exposed individuals in Burkina Faso. A total of 719 blood samples were collected in a series of three cross-sectional surveys at the start, peak, and end of the wet season. The seroprevalence of antibodies with specificity for the sexual stage antigens Pfs48/45 and Pfs230 was 2-fold lower (22 to 28%) than that for an asexual blood stage antigen glutamate-rich protein (GLURP) (65%) or for the preerythrocytic stage antigen circumsporozoite protein (CSP) (54%). The youngest children responded at frequencies similar to those for all four antigens but, in contrast with the immune responses to GLURP and CSP that increased with age independently of season and area of residence, there was no evidence for a clear age dependence of responses to Pfs48/45 and Pfs230. Anti-Pfs230 antibodies were most prevalent at the peak of the wet season (P < 0.001). Our findings suggest that naturally acquired immunity against Pfs48/45 and Pfs230 is a function of recent exposure rather than of cumulative exposure to gametocytes.

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Transmission-blocking immunity against malaria and other vector-borne diseases

Kaslow

1993

Current Opinion in Immunology

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High Frequency of Antibody Response to Plasmodium falciparum Gametocyte Antigens during Acute Malaria Infections in Papua New Guinea Highlanders

Cited by 19 publications

References 0 publications

Sexual-Stage Antibody Responses to P. falciparum in Endemic Populations

Sexual-Stage Antibody Responses to P. falciparum in Endemic Populations

Naturally Acquired Immune Responses to Plasmodium falciparum Sexual Stage Antigens Pfs48/45 and Pfs230 in an Area of Seasonal Transmission

Transmission-blocking immunity against malaria and other vector-borne diseases

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