High frequency of calcification in basal ganglia on brain computed tomography images in Japanese older adults

Abstract

Compared with previous reports, the frequency of calcification of the basal ganglia in this study markedly increased. This might be because of the increased number of older adults and the increased sensitivity of CT.

Deconstructing Fahr's disease/syndrome of brain calcification in the era of new genes

“…Calcifications limited to Globus pallidum can be also be linked to ageing and are prevalent in people over 60 years of age (5.5-20 %) [2].…”

“…Physiological calcification in brain can be seen in up to 20% of routine CT scans [1,2]. Pathological brain calcification can be due to parathyroid disorders, phacomatosis, and secondary to infections, inflammation or haemorrhage.…”

Brain gadolinium deposition after administration of gadolinium-based contrast agents

“…High concentration areas of gadolinium were the dentate nucleus, inner segment of the globus pallidus, and pulvinar of the thalamus [48,49], with iron or calcium also showing relatively higher concentrations in these regions [55,56]. Gadolinium is probably not transported passively, but rather by some biological mechanism(s) such as metal transporter(s) [57,58].…”

Fahr’s syndrome and clinical correlation: a case series and literature review

“…Others can remain asymptomatic throughout life [2]. The prevalence of BSPDC is unknown, but an incidence of basal ganglia calcification ranging from 0.3% to 1.2% has been reported in routine radiological examinations in older reports [27,72] and recently greatly increased (from 1.3% to 20.6%) in recent studies [52,71].…”