High Frequency of Coeliac Disease among Patients with Autoimmune Adrenocortical Failure

Abstract

CD is frequently associated with Addison's disease. The risk of developing CD seems to be higher than can be explained by the common DR3-DQ2 association alone. It is often asymptomatic or associated with unspecific symptoms. Addison patients should be screened for the presence of CD on a regular basis.

Celiac disease in North Italian patients with autoimmune Addison’s disease

“…These data revealed that the association between AAD and CD varies in different countries and, that in the Southern European population, the prevalence of CD is less frequent than that observed in the Northern European population (7,8). Nevertheless, the prevalence of CD in AAD in Northern Italy is highly significant: it is about 50-fold higher than the prevalence of CD in the general Northern Italian population, and is estimated to be 0.63 per 1000 births (4).…”

“…A review of the literature on 1557 European patients with AAD, collected from 1967 to 1996, shows that a clinical form of CD was present in 1.2-8% of the cases (1). Two recent studies of cohorts of patients from Northern Europe with AAD have demonstrated that the prevalence of CD (either clinical, subclinical or latent) ranges from 7.9 to 11.4% of the population (7,8).…”

“…Resulting from an analysis of the literature (7,8) and including our data, seven cases were described as having previously identified CD and AAD at the beginning of the study. Of these seven, six had developed CD before AAD and were under a gluten-free diet.…”

“…One patient was affected by CD before the study (1.3%), but five others (6.6%) were found to be positive for the IgA-EmA and/or IgA-tTGAbs and all were found to have CD following biopsy. Patients with AAD are affected by either clinical or latent CD in 7.9% of the cases in Norway (8).…”

Первичная надпочечниковая недостаточность: диагностика и менеджмент (по материалам 17th European Congress of Endocrinology, Dublin, Ireland 16–20 May, 2015)

“…В Европе доминируют аутоиммунные причины [1]. Примерно у половины пациентов с ПНН выявляют-ся сосуществующие аутоиммунные заболевания [1][2][3][4][5][7][8][9], комбинации которых классифицируют как не-сколько аутоиммунных полиэндокринных синдромов (АПС) [10][11][12][13].…”