High frequency of enterotoxigenic Bacteroides fragilis and Enterococcus faecalis in the paraffin-embedded tissues of Iranian colorectal cancer patients

Khodaverdi, Nasibeh; Zeighami, Habib; Jalilvand, Ahmad; Haghi, Fakhri; Hesami, Negar

doi:10.1186/s12885-021-09110-x

Cited by 23 publications

(12 citation statements)

References 25 publications

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“… 227 The esophageal type II microflora can produce abundant LPS due to the presence of Gram‐negative bacteria. 207 , 228 In addition to affecting cyclooxygenase 1/2, LPS can directly affect the lower esophageal sphincter, resulting in an increase in intragastric pressure and promoting the GERD occurrence, which leads to EAC development. 207 , 229 There is interesting evidence that in patients with BE and EAC, TLR4 is being expressed more strongly as a natural ligand of LPS.…”

Section: Mechanisms By Which Human Carcinogenic Microbiomes Promote C...mentioning

confidence: 99%

Human microbiomes in cancer development and therapy

Xia

Liu

et al. 2023

MedComm

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Colonies formed by bacteria, archaea, fungi, and viral groups and their genomes, metabolites, and expressed proteins constitute complex human microbiomes. An increasing evidences showed that carcinogenesis and disease progression were link to microbiomes. Different organ sources, their microbial species, and their metabolites are different; the mechanisms of carcinogenic or procancerous are also different. Here, we summarize how microbiomes contribute to carcinogenesis and disease progression in cancers of the skin, mouth, esophagus, lung, gastrointestinal, genital, blood, and lymph malignancy. We also insight into the molecular mechanisms of triggering, promoting, or inhibiting carcinogenesis and disease progress induced by microbiomes or/and their secretions of bioactive metabolites. And then, the strategies of application of microorganisms in cancer treatment were discussed in detail. However, the mechanisms by which human microbiomes function are still poorly understood. The bidirectional interactions between microbiotas and endocrine systems need to be clarified. Probiotics and prebiotics are believed to benefit human health via a variety of mechanisms, in particular, in tumor inhibition. It is largely unknown how microbial agents cause cancer or how cancer progresses. We expect this review may open new perspectives on possible therapeutic approaches of patients with cancer.

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Section: Mechanisms By Which Human Carcinogenic Microbiomes Promote C...mentioning

confidence: 99%

Human microbiomes in cancer development and therapy

Xia

Liu

et al. 2023

MedComm

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“…The efficacy of such an approach is influenced by multiple factors, including the sampling method, reliability of detection, and the stage at which these bacteria can be detected. In most studies using tissue biopsies and assessing ETBF prevalence by quantitative real-time PCR (qPCR), ETBF abundance is positively correlated with tumor stage 56 , 57 , 62 , 67 or equally enriched across tumor stage. 68 However, in a recent study directly comparing the prognostic value of ETBF to four other CRC-associated bacteria in a French cohort, ETBF was the only species differentially enriched in fresh fecal samples from patients with early adenomas assessed by qPCR.…”

Section: Proposed Carcinogenic Bacteriamentioning

confidence: 99%

“…Enterococcus faecalis ( E. faecalis ) is among the most prevalent commensal enterococci found in human stool and is enriched in fecal 125 and formalin-fixed paraffin-embedded (FFPE) 67 samples from CRC patients. However, whether E. faecalis colonization modules intestinal tumor development is debated 126 and recent evidence suggests strain-specific differences may alternatively elicit pro- or anti-tumorigenic effects in normal intestinal epithelial and tumor cells.…”

Section: Proposed Carcinogenic Bacteriamentioning

confidence: 99%

Intestinal bacteria and colorectal cancer: etiology and treatment

Dougherty

Jobin

2023

Gut Microbes

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The etiology of colorectal cancer (CRC) is influenced by bacterial communities that colonize the gastrointestinal tract. These microorganisms derive essential nutrients from indigestible dietary or host-derived compounds and activate molecular signaling pathways necessary for normal tissue and immune function. Associative and mechanistic studies have identified bacterial species whose presence may increase CRC risk, including notable examples such as Fusobacterium nucleatum , Enterotoxigenic Bacteroides fragilis , and pks + E. coli . In recent years this work has expanded in scope to include aspects of host mutational status, intra-tumoral microbial heterogeneity, transient infection, and the cumulative influence of multiple carcinogenic bacteria after sequential or co-colonization. In this review, we will provide an updated overview of how host-bacteria interactions influence CRC development, how this knowledge may be utilized to diagnose or prevent CRC, and how the gut microbiome influences CRC treatment efficacy.

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“…Association of E. faecalis with different forms of cancer through reviewed studies was shown in Table 1 (Ref. [12,36,50,73]).…”

Section: E Faecalis Positive Av and Hpv In The Vaginal Floramentioning

confidence: 99%

Aerobic Vaginitis: is Enterococcus faecalis Another Risk Factor in the Progression of Cervical Intraepithelial Neoplasia to Cervical Cancer—Literature Review

Jahic¹,

Cerovac²

2022

Clin. Exp. Obstet. Gynecol.

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Objective: The aim of our review article is to show Enterococcus faecalis (E. faecalis) as a risk factor of cervical cancer. Mechanism: Aerobic vaginitis (AV) is the absence of a balance of vaginal flora containing aerobic and intestinal pathogens, varying degrees of vaginal inflammation and immature epithelial cells. The causes of AV responsible for inflammatory changes are: E. faecalis, Esherichia coli, group B streptococcus and Staphylococcus aureus. The pathogenic effect of aerobic microorganisms such as E. faecalis shows that it causes spontaneous abortion, premature birth, puerperal sepsis, abscesses, and urinary tract infections. Findings in Brief: AV caused by E. faecalis is more common in low-grade and high-grade cervical intraepithelial neoplasia (CIN) than in women with a normal Pap test and is thought to contribute to the progression of cervical cancer. E. faecalis produces hydrogen superoxide which causes chromosomal instability in intestinal epithelial cell infection, which is considered a key factor in the carcinogenic process. The presence of the Human papilloma virus (HPV) 16 gene and genome in E. faecalis in cervical cancer biopsy material leads to a specific link that may be a risk factor in the progression of CIN toward cancer. The presence of HPV in this bacteria can lead to persistent HPV infection, CIN development and progression to cervical cancer. Conclusions: Increased vaginal pH, lactobacilli deficiency, and the ability of E. faecalis to contain HPV-16 in episomal form in E. faecalis-induced AV could be key promoters of persistence and proliferation of cervical HPV as a risk factor in development of CIN and cervical cancer.

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High frequency of enterotoxigenic Bacteroides fragilis and Enterococcus faecalis in the paraffin-embedded tissues of Iranian colorectal cancer patients

Cited by 23 publications

References 25 publications

Human microbiomes in cancer development and therapy

Human microbiomes in cancer development and therapy

Intestinal bacteria and colorectal cancer: etiology and treatment

Aerobic Vaginitis: is Enterococcus faecalis Another Risk Factor in the Progression of Cervical Intraepithelial Neoplasia to Cervical Cancer—Literature Review

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