High frequency of human papillomavirus infection in carcinoma of the urinary bladder

Anwar, Khurshid; Naiki, Hironobu; Nakakuki, Kazuya; Inuzuka, Manabu

doi:10.1002/1097-0142(19921001)70:7<1967::aid-cncr2820700726>3.0.co;2-8

Cited by 97 publications

(61 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…46 Whether HPV has a role in the carcinogenesis of bladder cancer has been debated. [47][48][49][50] Esophageal cancer (squamous cell carcinoma) has been positively associated with HPV, with a stronger association in high-risk populations, [51][52][53][54][55] but contradictory results have been reported. 56 Cigarette smoking is considered as the most important factor in the etiology of lung cancer, but detection of circulating HPV DNA in blood samples has been suggested as a risk marker for lung cancer, 57 and play a role in the carcinogenesis of lung cancer.…”

Section: Discussionmentioning

confidence: 99%

Cancer risk among patients with condylomata acuminata

Nordenvall

Chang

Adami

et al. 2006

Intl Journal of Cancer

View full text Add to dashboard Cite

Condylomata acuminata have been shown to increase the risk of anogenital cancers. However, previous studies have been of limited sample size and/or short follow-up duration, which prevent precise estimates of long-term excess risk, especially for specific cancer sites. We estimated the risk of specific cancers in a large cohort of hospitalized patients with condylomata acuminata, as recorded in the Swedish Inpatient Register between 1965 and 1999. Altogether, 10,971 patients (1,685 men and 9,286 women) were followed through 1999 for a median of 13 years. The standardized incidence ratio (SIR)-the ratio of the observed number of cancers to the number expected on the basis of the incidence in the Swedish population at large-was used as a measure of relative risk. After excluding the first-year of follow-up, we observed 43 cases of anogenital cancer in women, and 7 cases in men. Risks were elevated for cancers of the vulva (N 5 13, SIR 5 10.2, 95% confidence interval (CI) 5 5.4-17.4), vagina (N 5 4, SIR 5 12.0, 95% CI 5 3.3-30.7) and penis (N 5 5, SIR 5 21.9, 95% CI 5 7.1-51.2). There was a moderate excess risk of cervical cancer in situ (N 5 259, SIR 5 1.9, 95% CI 5 1.7-2.1), but not invasive cervical cancer. Excess risks of esophageal, buccal cavity, nonmelanoma skin, lung and bladder cancers, and Hodgkin and non-Hodgkin lymphoma, were also observed in both men and women. In conclusion, condylomata acuminata are strongly associated with increased risk of cancers of the vulva, vagina, penis and anus, as well as some nonanogenital malignancies, but not invasive cervical cancer. ' 2006 Wiley-Liss, Inc.

show abstract

Section: Discussionmentioning

confidence: 99%

Cancer risk among patients with condylomata acuminata

Nordenvall

Chang

Adami

et al. 2006

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

“…Recent studies indicate that some HPVs are associated with bladder carcinoma (Del Mistro et al, 1988;Kitamura et al, 1988;Querci Della Rovere et al, 1988;Bryant et al, 1991;Anwar et al, 1992;Chetsanga et al, 1992; LopezBeltran et al, 1992a;Furihata et al, 1993;Chang et al, 1994; Lopez-Beltran and Munioz, 1995). However, the exact incidence of HPV DNA involved in TCC of the bladder remains controversial (Chang et al, 1994; Lopez-Beltran and Muiioz, 1995), since the reported incidence varies between 2.5% and 62% (Anwar et al, 1992;Chetsanga et al, 1992;Lopez-Beltran et al, 1992a; Lopez-Beltran and Mufioz 1995).…”

mentioning

confidence: 99%

Human papillomavirus DNA as a factor determining the survival of bladder cancer patients

López-Beltrán

Escudero²,

Vicioso³

et al. 1996

Br J Cancer

View full text Add to dashboard Cite

Summary The natural history of transitional cell carcinoma (TCC) of the urinary bladder is somewhat variable, with a significant number of tumour recurrences that occasionally evolve towards an infiltrating disease. The aim of this study was to investigate the presence of human papillomavirus (HPV) DNA in 76 TCC specimens, and then correlate such findings with the overall patient survival. However, other classical prognostic clinical and pathological variables such as pathological grade and stage, koilocytosis, age and sex were also tested. HPV DNA was investigated by means of the highly sensitive polymerase chain reaction (PCR). DNA primers specific for HPV types 6, 11, 16 and 18 were used. Our results showed that 7 (9.21%) out of 76 such cases were reactive for HPV 16 DNA; one of them also reacted with HPV 6 DNA. The statistical analysis was done by the Kaplan-Meier method, Wilcoxon's generalised test for studying the differences in survival curves and Cox's regression analysis for independent prognostic factors. A significant P-value was found for pathological grade (P<0.0001) and stage (P<0.0001), HPV 16 DNA (P = 0.0418) and koilocytosis (P = 0.0140). Thus, pathological grade was the only independent factor in the bladder cancer survival. These observations may prove useful in prognostic stratification of patients with TCC of the bladder.Keywords: human papillomavirus; polyamerase chain reaction; transitional cell tumour; urinary bladderThe presence of human papillomavirus (HPV) DNA has been reported most frequently in association with cervical dysplasias which can progress to malignancies, and benign condylomata acuminata (Stoler et al., 1992;Donalson et al., 1993). Recent studies indicate that some HPVs are associated with bladder carcinoma (Del Mistro et al., 1988;Kitamura et al., 1988;Querci Della Rovere et al., 1988;Bryant et al., 1991;Anwar et al., 1992;Chetsanga et al., 1992; LopezBeltran et al., 1992a;Furihata et al., 1993;Chang et al., 1994; Lopez-Beltran and Munioz, 1995). However, the exact incidence of HPV DNA involved in TCC of the bladder remains controversial (Chang et al., 1994; Lopez-Beltran and Muiioz, 1995), since the reported incidence varies between 2.5% and 62% (Anwar et al., 1992;Chetsanga et al., 1992;Lopez-Beltran et al., 1992a; Lopez-Beltran and Mufioz 1995). Negative results have been reported by Chang et al. (1994) and Ashfaq and Vuitch (1994). The prognostic implication of HPV infection in bladder cancer survival was suggested by Lopez-Beltran et al. (1992a) andFurihata et al. (1993), using non-isotopic DNA in situ hybridisation.The aim of the present research was to investigate HPV incidence in 76 TCC specimens, using polymerase chain reaction (PCR) analysis, and then to correlate such findings with the overall patient survival. This study also included other classic prognosticators, such as the pathological grade and stage, patient age and sex, and koilocytosis. An attempt is also made to ascertain their possible prognostic implication in bladder cancer survival. Materials a...

show abstract

“…It seems that geographical location has an impact on the association between HPV and bladder cancer. Indeed, it has been reported that HPV was detected in urothelial carcinoma at the highest rates in Southeast Asia (Japan and Hong Kong, 31% and 81%, respectively) [35,36] and in Europe (Italy and Finland, 50% and 57% respectively) [32,37]. Mean values have been reported in Europe and in North America (Canada), with frequencies not exceeding 39% [38,39].…”

Section: Discussionmentioning

confidence: 99%

Human papillomavirus detection in Moroccan patients with bladder cancer

Berrada

Albouzidi

Ameur

et al. 2013

J Infect Dev Ctries

View full text Add to dashboard Cite

Introduction: Human papillomavirus (HPV) is associated with more human cancers than any other virus. Many studies have investigated the association between bladder cancer and HPV but the results remain controversial. The aim of the present study is to evaluate whether HPV have an etiological role in bladder carcinogenesis among Moroccan patients. Methodology: Forty-eight fresh biopsies (43 bladder tumors and 5 non-tumor samples) were collected for this purpose. Nested PCR with the consensus MY09/MY11 and GP5

show abstract

High frequency of human papillomavirus infection in carcinoma of the urinary bladder

Cited by 97 publications

References 25 publications

Cancer risk among patients with condylomata acuminata

Cancer risk among patients with condylomata acuminata

Human papillomavirus DNA as a factor determining the survival of bladder cancer patients

Human papillomavirus detection in Moroccan patients with bladder cancer

Contact Info

Product

Resources

About