High Frequency of Sleep Disorders in Parkinson’s Disease and Its Relationship with Quality of Life

Abstract

Objectives: To determine the frequency of major sleep disorders in patients with Parkinson’s disease (PD), diagnosed according to the third international classification of sleep disorders, and assess the relationship of those disorders with the quality of life. Methods: A cross-sectional study was performed involving 88 consecutive patients with PD from outpatient clinic. Participants were subjected to clinical interviews, assessment using standardized scales (Epworth Sleepiness Scale, PD Questionnaire, Pittsburgh sleep quality index (PSQI) and, for individuals with a diagnosis of RLS/WED, International RLS/WED grading scale), and video-polysomnography. Results: We observed sleep disorders in 96.5% of the participants, with REM-sleep behavior disorder found in 62.5%, obstructive sleep apnea in 62.5%, insomnia in 55.7%, and restless legs syndrome in 28.4%. We observed a correlation between health-related quality of life with the PSQI and the Epworth sleepiness scale. Conclusion: Patients with PD have a high prevalence of sleep disorders. The quality of sleep and excessive daytime sleepiness significantly affect the quality of life in these individuals.

Efficacy of cognitive behavioral therapy for insomnia comorbid to Parkinson's disease: A focus on psychological and daytime functioning with a single‐case design with multiple baselines

“…Quality of life is altered in PD, and particularly in patients with ID (Sobreira‐Neto et al, ). We documented that CBT‐i has positive and sustained effect over time on this variable.…”

“…Sleep disorders are probably the most common non-motor complications associated with PD, with sleep disorders noted in up to 96.5% of patients diagnosed (Sobreira-Neto et al, 2017). More specifically, when standardized criteria are used (American Academy of Sleep Medicine, 2014;American Psychiatric Association, 2013), it is estimated that more than half of patients with PD suffered from insomnia disorder (ID) with deleterious effects on quality of life (Sobreira-Neto et al, 2017). ID is therefore a common non-motor complication which warrants particular attention in PD (Uhlig, Sand, Ødegård, & Hagen, 2014).…”

Global cognitive performance is associated with sleep efficiency measured by polysomnography in patients with Parkinson's disease

“…Sleep disorders are also prevalent in PD and can occur at any stage of the disease . It affects up to two‐thirds of the patients, and they are often associated with impairment in quality of life . PD patients may present with many different sleep disorders, including insomnia, REM sleep behavioral disorder (RBD), obstructive sleep apnea (OSA), and restless legs syndrome (RLS) …”

The Parkinson's Disease Sleep Scale–2 (PDSS‐2): Validation of the Spanish Version and Its Relationship With a Roommate‐Based Version

“…These sleep disorders may be present from PD's prodromal phase, may increase their presence and severity over time, and may be highly prevalent in the disease's advanced stages . Furthermore, sleep disorders in PD have been correlated with increased disease‐related disability and significant quality‐of‐life deterioration …”