High-frequency rTMS treatment increases left prefrontal myo-inositol in young patients with treatment-resistant depression

Zheng, Huirong; Zhang, Li; Li, Lingjiang; Liu, Peng; Gao, Junling; Liu, Xiaoyun; Zou, Juan; Zhang, Yan; Li, Jun; Zhang, Zhijun; Li, Zexuan; Men, Weiwei

doi:10.1016/j.pnpbp.2010.06.009

Cited by 65 publications

(81 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An inspection of the weighted effect sizes d for each of the N=58 studies revealed that N=4 studies (all “new” studies)38–41 were outliers in the current analysis. Specifically, weighted d s in these studies were statistically significantly higher than the overall mean weighted d of all other studies (Figures S1 and S2).…”

Section: Resultsmentioning

confidence: 91%

“…Specifically, a large antidepressant effect of rTMS was observed in the total of N=86 patients (63%–65% males) on concurrent antidepressants, with unipolar, non-psychotic depression, and with moderate–severe treatment-resistance using long (20 sessions), left-fast paradigms with a high number (3,000) of stimuli/session 38,40,41. Therefore, in contrast to female patients, male patients with more severe major depression might require longer, left-fast paradigms with more stimuli per session to show an antidepressant response to rTMS during the double-blind phases of studies.…”

Section: Discussionmentioning

confidence: 99%

“…“Combined” indicates that more than one depression scale was used in a study and the effect sizes according to the multiple scales were combined). According to the P -values, 4/18 “new” studies were classified as outliers: Zheng et al 2010,90 Ray et al 2011,75 Peng et al 2012,74 and Spampinato et al 2013 81. These studies were excluded from all subsequent analyses.…”

Section: Supplementary Materialsmentioning

confidence: 99%

See 2 more Smart Citations

More female patients and fewer stimuli per session are associated with the short-term antidepressant properties of repetitive transcranial magnetic stimulation (rTMS): a meta-analysis of 54 sham-controlled studies published between 1997–2013

Kedzior¹,

Azorina²,

Reitz³

2014

NDT

View full text Add to dashboard Cite

BackgroundRepetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex (DLPFC) appears to have short-term antidepressant properties. The aim of the current study was to update our previous meta-analysis and to investigate factors associated with the antidepressant properties of rTMS.MethodFollowing a systematic literature search conducted in Medline and PsycInfo, N=14 sham-controlled, parallel design studies (published after 2008 to August 2013) that had utilized rTMS of the DLPFC in major depression were included in the current meta-analysis. The sensitivity and moderator analyses also included data from N=40 studies (published in 1997–2008) from our previous meta-analysis. The effect size (Cohen’s d) in each study was the standardized difference in mean depression scores (on Hamilton Depression Rating Scale, Beck Depression Inventory, Montgomery Åsberg Depression Rating Scale) from baseline to final (after last session) in rTMS compared to sham groups.ResultsAccording to a random-effects model with inverse-variance weights, depression scores were significantly reduced after rTMS compared to sham in studies published from 2008–2013 based on N=659 patients (overall mean weighted d=−0.42, 95% confidence interval: −0.66, −0.18, P=0.001). Combining studies from our past and current meta-analyses (published in 1997–2013; N=54) revealed that depression was significantly reduced after left-fast (>1 Hz), right-slow (≤1 Hz), and bilateral (or sequential) rTMS of DLPFC compared to sham. Significant antidepressant properties of rTMS were observed in studies with patients who were treatment resistant, unipolar (or bipolar), non-psychotic, medication-free (or started on antidepressants concurrently with rTMS). According to univariate meta-regressions, depression scores were significantly lower in studies with more female patients and fewer stimuli per session. There was little evidence that publication bias occurred in the analysis.ConclusionAccording to this study, the largest meta-analysis to date, short-term antidepressant properties of rTMS are independent of concurrent antidepressants and might depend on sex and the number of stimuli per session.

show abstract

Section: Resultsmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Supplementary Materialsmentioning

confidence: 99%

See 1 more Smart Citation

More female patients and fewer stimuli per session are associated with the short-term antidepressant properties of repetitive transcranial magnetic stimulation (rTMS): a meta-analysis of 54 sham-controlled studies published between 1997–2013

Kedzior¹,

Azorina²,

Reitz³

2014

NDT

View full text Add to dashboard Cite

show abstract

“…Consistently, proton magnetic resonance imaging ( 1 H-MRS) studies of patients with major depressive disorder (MDD) report reduced levels of myo-Insoitol in prefrontal and anterior cingulate cortex (ACC; Frey et al, 1998;Coupland et al, 2005;Chen et al, 2014). Conversely, positive clinical outcome in MDD is associated with increased myo-Inositol levels (Chen et al, 2014;Zheng et al, 2010). These data indicate that reduced myo-Inositol in MDD is primarily associated with depression symptoms rather than being secondary to treatment.…”

Section: Introductionmentioning

confidence: 89%

Evaluation of Myo-Inositol as a Potential Biomarker for Depression in Schizophrenia

Chiappelli

Rowland

Wijtenburg

et al. 2015

Neuropsychopharmacol

View full text Add to dashboard Cite

“…Triggs et al 2010;Zheng et al 2010;Zhang et al 2011;Blumberger et al 2012;Fitzgerald et al 2012;Hernández-Ribas et al 2013; Bakim et al in press). SeeFig.…”

mentioning

confidence: 99%

Response, remission and drop-out rates following high-frequency repetitive transcranial magnetic stimulation (rTMS) for treating major depression: a systematic review and meta-analysis of randomized, double-blind and sham-controlled trials

et al. 2013

View full text Add to dashboard Cite

show abstract

High-frequency rTMS treatment increases left prefrontal myo-inositol in young patients with treatment-resistant depression

Cited by 65 publications

References 52 publications

More female patients and fewer stimuli per session are associated with the short-term antidepressant properties of repetitive transcranial magnetic stimulation (rTMS): a meta-analysis of 54 sham-controlled studies published between 1997–2013

More female patients and fewer stimuli per session are associated with the short-term antidepressant properties of repetitive transcranial magnetic stimulation (rTMS): a meta-analysis of 54 sham-controlled studies published between 1997–2013

Evaluation of Myo-Inositol as a Potential Biomarker for Depression in Schizophrenia

Response, remission and drop-out rates following high-frequency repetitive transcranial magnetic stimulation (rTMS) for treating major depression: a systematic review and meta-analysis of randomized, double-blind and sham-controlled trials

Contact Info

Product

Resources

About

High-frequency rTMS treatment increases left prefrontal myo-inositol in young patients with treatment-resistant depression

Cited by 65 publications

References 52 publications

More female patients and fewer stimuli per session are associated with the short-term antidepressant properties of repetitive transcranial magnetic stimulation (rTMS): a meta-analysis of 54 sham-controlled studies published between 1997&ndash;2013

More female patients and fewer stimuli per session are associated with the short-term antidepressant properties of repetitive transcranial magnetic stimulation (rTMS): a meta-analysis of 54 sham-controlled studies published between 1997&ndash;2013

Evaluation of Myo-Inositol as a Potential Biomarker for Depression in Schizophrenia

Response, remission and drop-out rates following high-frequency repetitive transcranial magnetic stimulation (rTMS) for treating major depression: a systematic review and meta-analysis of randomized, double-blind and sham-controlled trials

Contact Info

Product

Resources

About

More female patients and fewer stimuli per session are associated with the short-term antidepressant properties of repetitive transcranial magnetic stimulation (rTMS): a meta-analysis of 54 sham-controlled studies published between 1997–2013

More female patients and fewer stimuli per session are associated with the short-term antidepressant properties of repetitive transcranial magnetic stimulation (rTMS): a meta-analysis of 54 sham-controlled studies published between 1997–2013