High frequency stimulation of subthalamic nucleus results in behavioral recovery by increasing striatal dopamine release in 6-hydroxydopamine lesioned rat

He, Zheng; Jiang, Yijun; Xu, Huamin; Jiang, Hong; Jia, Wenting; Sun, Peng; Xie, Junxia

doi:10.1016/j.bbr.2014.01.014

Cited by 28 publications

(21 citation statements)

References 44 publications

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“…The DBS-related decreases in the levels of extracellular DA and its metabolites in the dorsal part of the striatum described by Walker et al [70] are in line with a decreased concentration of the DA metabolite DOPAC (3-4-dihydroxyphenylacetic acid) in the extracellular fluid of the striatum found by Yamamoto et al [71]. In contrast, He et al [72] described a DBS-induced increase in the extracellular striatal DA concentration. Recently, GABAergic activation by chronic DBS has been shown to be responsible for the compensation of motor asymmetries in hemiparkinsonian rats [73].…”

Section: Discussionmentioning

confidence: 62%

Deep Brain Stimulation of Hemiparkinsonian Rats with Unipolar and Bipolar Electrodes for up to 6 Weeks: Behavioral Testing of Freely Moving Animals

Badstuebner

Gimsa

Weber

et al. 2017

Parkinson's Disease

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Although the clinical use of deep brain stimulation (DBS) is increasing, its basic mechanisms of action are still poorly understood. Platinum/iridium electrodes were inserted into the subthalamic nucleus of rats with unilateral 6-OHDA-induced lesions of the medial forebrain bundle. Six behavioral parameters were compared with respect to their potential to detect DBS effects. Locomotor function was quantified by (i) apomorphine-induced rotation, (ii) initiation time, (iii) the number of adjusting steps in the stepping test, and (iv) the total migration distance in the open field test. Sensorimotor neglect and anxiety were quantified by (v) the retrieval bias in the corridor test and (vi) the ratio of migration distance in the center versus in the periphery in the open field test, respectively. In our setup, unipolar stimulation was found to be more efficient than bipolar stimulation for achieving beneficial long-term DBS effects. Performance in the apomorphine-induced rotation test showed no improvement after 6 weeks. DBS reduced the initiation time of the contralateral paw in the stepping test after 3 weeks of DBS followed by 3 weeks without DBS. Similarly, sensorimotor neglect was improved. The latter two parameters were found to be most appropriate for judging therapeutic DBS effects.

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Section: Discussionmentioning

confidence: 62%

Deep Brain Stimulation of Hemiparkinsonian Rats with Unipolar and Bipolar Electrodes for up to 6 Weeks: Behavioral Testing of Freely Moving Animals

Badstuebner

Gimsa

Weber

et al. 2017

Parkinson's Disease

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“…We suggest that this result may be related to a compensatory mechanism. In this respect, previous studies have reported that remaining dopaminergic neurons in SNpc could sustain a more intense expression of TH to replace the new dopamine demand in their terminals, converting more tyrosine into dopamine [ 54 ]. This new dopamine demand would occur in response to reserpine action on VMAT, leading to the sustained expression of TH densitometry levels reported in dorsal striatum of reserpine groups.…”

Section: Discussionmentioning

confidence: 99%

Passiflora cincinnata Extract Delays the Development of Motor Signs and Prevents Dopaminergic Loss in a Mice Model of Parkinson’s Disease

Brandão

Nôga

Dierschnabel

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Passiflora cincinnata Masters is a Brazilian native species of passionflower. This genus is known in the American continent folk medicine for its diuretic and analgesic properties. Nevertheless, few studies investigated possible biological effects of P. cincinnata extracts. Further, evidence of antioxidant actions encourages the investigation of possible neuroprotective effects in animal models of neurodegenerative diseases. This study investigates the effect of the P. cincinnata ethanolic extract (PAS) on mice submitted to a progressive model of Parkinson's disease (PD) induced by reserpine. Male (6-month-old) mice received reserpine (0.1 mg/kg, s.c.), every other day, for 40 days, with or without a concomitant treatment with daily injections of PAS (25 mg/kg, i.p.). Catalepsy, open field, oral movements, and plus-maze discriminative avoidance evaluations were performed across treatment, and immunohistochemistry for tyrosine hydroxylase was conducted at the end. The results showed that PAS treatment delayed the onset of motor impairments and prevented the occurrence of increased catalepsy behavior in the premotor phase. However, PAS administration did not modify reserpine-induced cognitive impairments. Moreover, PAS prevented the decrease in tyrosine hydroxylase immunostaining in the substantia nigra pars compacta (SNpc) induced by reserpine. Taken together, our results suggested that PAS exerted a neuroprotective effect in a progressive model of PD.

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“…49 The difference observed between groups at the second week suggests a positive combined STN-HFS + graft effect on the surviving dopaminergic grafted cells in the striatum, and on the rescue of dopamine-producing cells in the midbrain. 14,15,[50][51][52] Nevertheless, in the current study, STN neuromodulation improved limb-use asymmetry in the cylinder test even before transplantation. The assessment of forelimb akinesia has translational clinical relevance and may be analogous to limb akinesia and the difficulty of movement initiation often seen in patients with degeneration of nigrostriatal dopaminergic neurons.…”

Section: Behavioral Assessmentmentioning

confidence: 86%

Continuous High-Frequency Stimulation of the Subthalamic Nucleus Improves Cell Survival and Functional Recovery Following Dopaminergic Cell Transplantation in Rodents

Furlanetti

Cordeiro

et al. 2015

Neurorehabil Neural Repair

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Subthalamic nucleus (STN) high-frequency stimulation (HFS) is a routine treatment in Parkinson's disease (PD), with confirmed long-term benefits. An alternative, but still experimental, treatment is cell replacement and restorative therapy based on transplanted dopaminergic neurons. The current experiment evaluated the potential synergy between neuromodulation and grafting by studying the effect of continuous STN-HFS on the survival, integration, and functional efficacy of ventral mesencephalic dopaminergic precursors transplanted into a unilateral 6-hydroxydopamine medial forebrain bundle lesioned rodent PD model. One group received continuous HFS of the ipsilateral STN starting a week prior to intrastriatal dopaminergic neuron transplantation, whereas the sham-stimulated group did not receive STN-HFS but only dopaminergic grafts. A control group was neither lesioned nor transplanted. Over the following 7 weeks, the animals were probed on a series of behavioral tasks to evaluate possible graft and/or stimulation-induced functional effects. Behavioral and histological data suggest that STN-HFS significantly increased graft cell survival, graft-host integration, and functional recovery. These findings might open an unexplored road toward combining neuromodulative and neuroregenerative strategies to treat severe neurologic conditions.

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High frequency stimulation of subthalamic nucleus results in behavioral recovery by increasing striatal dopamine release in 6-hydroxydopamine lesioned rat

Cited by 28 publications

References 44 publications

Deep Brain Stimulation of Hemiparkinsonian Rats with Unipolar and Bipolar Electrodes for up to 6 Weeks: Behavioral Testing of Freely Moving Animals

Deep Brain Stimulation of Hemiparkinsonian Rats with Unipolar and Bipolar Electrodes for up to 6 Weeks: Behavioral Testing of Freely Moving Animals

Passiflora cincinnata Extract Delays the Development of Motor Signs and Prevents Dopaminergic Loss in a Mice Model of Parkinson’s Disease

Continuous High-Frequency Stimulation of the Subthalamic Nucleus Improves Cell Survival and Functional Recovery Following Dopaminergic Cell Transplantation in Rodents

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