Dynamic instabilities during flow boiling in a uniformly heated microchannel are investigated. The focus of this Part 2 of the study is on the effect of operating conditions on the instability type and the resulting time-periodic hydrodynamic and thermal oscillations, which have been established after the initial boiling incipience event. Part 1 of this study investigated the rapid-bubble-growth instability at the onset of boiling in the same experimental facility. Fluid is driven through the single 500 μm-diameter glass microchannel by maintaining a constant pressure difference between a pressurized upstream reservoir and a reservoir downstream that is open to the ambient, so as to resemble the hydrodynamic boundary conditions of an individual channel in a parallel-channel heat sink. Simultaneous high-frequency measurement of pressure drop, mass flux, and wall temperature is synchronized to high-speed flow visualizations enabling transient characterization of the thermal-fluidic behavior. The effect of flow inertia, inlet liquid subcooling, and heat flux on the hydrodynamic and thermal oscillations and time-averaged