High-frequency ultrasonography of psoriatic skin: A non-invasive technique in the evaluation of the entire skin of patients with psoriasis: A pilot study

Şomlea, Mihaela; Boca, Andreea; Pop, A.; Ilieş, Roxana Flavia; Vesa, Ştefan Cristian; Tătaru, Alexandru

doi:10.3892/etm.2019.8140

Cited by 19 publications

(20 citation statements)

References 17 publications

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“…The increase in SLEB in psoriatic lesions correlated with the severity of inflammatory infiltration 28 . In a study by Gupta et al, the magnitude of this parameter correlated most favorably with the severity of the clinical state of psoriatic lesions (mPASI) 6 .…”

Section: Discussionmentioning

confidence: 96%

D‐chiro‐inositol as a treatment in plaque psoriasis: A randomized placebo‐controlled clinical trial

Owczarczyk‐Saczonek

Czerwińśka

Wygonowska

et al. 2020

Dermatologic Therapy

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Cyclitols are widely available natural sugars which do not exert toxic effects. Their anti‐inflammatory and antioxidant properties may be used in the treatment of psoriasis. The aim of this placebo‐controlled, double‐blind study was to evaluate the clinical effects of D‐chiro‐inositol (DCI) in mild plaque psoriasis (46 psoriatic patients and 10 healthy volunteers). Three stable psoriatic plaques were selected for evaluation in every patient. Different samples were applied on each lesion twice a day: vehiculum without an active agent, containing 1% DCI and 0.25% DCI. The lesions were assessed using the PSI, VAS scale, and the objective measurement of hydration, transepidermal water loss (TEWL), elasticity, and thickness (DermaLab Combo) at 0, 3, and 6 weeks. PSI and VAS were improved in all groups without significant statistical differences. 1% DCI sample presented the highest statistically significant increase in the hydration of 50%, but it was still significantly lower than in healthy controls. TEWL increased for 1% DCI, which was a statistically significant difference compared to 0.25% DCI and still higher than in controls. An improvement in elasticity was observed in all lesions—it was statistically significant for 1% DCI. The thickness of the lesion decreased for 1% DCI, but the change was not statistically significant. Subepidermal low‐echogenic band showed a decreasing tendency in all groups, but it was not statistically significant. Favorable 1% DCI sample results indicate that it may be used as an adjuvant to the local treatment of psoriasis.

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Section: Discussionmentioning

confidence: 96%

D‐chiro‐inositol as a treatment in plaque psoriasis: A randomized placebo‐controlled clinical trial

Owczarczyk‐Saczonek

Czerwińśka

Wygonowska

et al. 2020

Dermatologic Therapy

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“…Plaques psoriasis examination using US shows the epidermal and dermal thickening with variable vascularization. The subepidermal low‑echogenic band (SLEB) corresponding to the inflammation in the upper dermis may be particularly detectable in the most active stages of active disease 19,20 . Differentiating discoid eczema from BD on clinical grounds can be difficult.…”

Section: Discussionmentioning

confidence: 99%

Imaging findings of Bowen's disease: A comparison between ultrasound biomicroscopy and conventional high‐frequency ultrasound

Wang

et al. 2020

Skin Research and Technology

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Objectives: To compare the imaging findings of Bowen's disease (BD) between ultrasound biomicroscopy (UBM) and conventional high-frequency ultrasound (HFUS). Methods: A total of 29 pathologically proven BD lesions in 28 patients were retrospectively enrolled in the study, and all were after surgery. All the lesions were imaged with both UBM and HFUS. The imaging features on HFUS and UBM were analyzed and compared. The diagnostic results of ultrasound for BD were referenced with pathology results. Results: All the 29 (100%) BD lesions appeared hypoechogenicity, solid component, and superficial hyperechoic layer (ie, keratinization) on both UBM and HFUS. The typical imaging feature of BD lesions, that was, infiltration depth confined to the epidermis, was visualized in 25 (86.2%, 25/29) lesions on UBM whereas 15 (51.7%, 15/29) on HFUS (P = .002). A "wave sign," which corresponds to the surface keratinization of BD lesion, was visualized in 17 (58.6%, 17/29) of BD lesions on UBM whereas 6 (20.7%, 6/29) on HFUS (P = .001). UBM and HFUS correctly diagnosed 25 (86.2%, 25/29) and 15 (51.7%, 15/29) BD lesions, respectively (P = .002). Conclusions: Bowen's disease has some typical imaging features on US. The "wave sign" of the superficial hyperechoic layer and the clear borderline between the tumor in epidermis and the slightly hyperechoic dermis layer are better depicted by UBM in comparison with HFUS, which leads to a more accurate diagnosis of BD. UBM has potential to be used as a diagnostic tool for characterization of BD on account of its high resolution.

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“…methotrexate, cyclosporine, acitretin) or biological treatment (e.g. Humira, Stelara, Cosentyx) [14][15][16] . Therapeutic e cacy, de ned as a diminishment in psoriasis clinical scores, does not occur instantly, and patients may not respond to therapy at all.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of skin-surface interleukin 1 alpha, interleukin-1 Receptor Antagonist, CXCL-1/2 and beta-defensin-1 as non-invasive biomarkers for monitoring psoriasis vulgaris

Orro¹,

Salk²,

Abram³

et al. 2020

Preprint

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Background: Psoriatic skin is typically evaluated through visual assessment of its clinical hallmarks: thickness, redness and scaling of skin lesions. Sonography is used to physically monitor disease severity through physical assessment of the skin outer layers. Both methods assess consequences of inflammation rather than the molecular basis of disease. The aim of the current study was to assess 1) whether expression patterns of IL-1α, IL-1RA, CXCL-1, CXCL-2, and hBD-1, examples of proteins known to drive psoriasis pathology, can be measured non-invasively from the skin surface, 2) whether expression patterns of these proteins correlate with disease severity, and 3) whether skin surface expression of these proteins can be used to measure pharmacodynamic effects of psoriasis treatment. Results: Using non-invasive FibroTx TAP technology for sampling and measurements of proteins from the skin of psoriasis patients revealed clear differences of IL-1α, IL-1RA, CXCL-1/2 on lesional skin when compared to non-lesional skin or skin from healthy volunteers. Comparing these expression patterns with visual assessment of thickness, redness and scaling of skin lesions revealed no significant quantitative correlations, with the exception of a weak correlation between CXCL-1/2 and thickness of lesions. Similarly, there were no significant correlations between FibroTx TAP measurements and ultrasound measurements, with the exception of a weak correlation between CXCL-1/2 and SLEB thickness. The potential of these skin-surface biomarkers were studied by monitoring skin lesions of psoriasis patients undergoing narrow-band UVB (311 nm) phototherapy. During the course of UVB treatment, clear patterns towards normalisation of IL-1RA and CXCL-1/2 were observed on lesions measured. Conclusions: Skin surface measurements of proteins involved in psoriasis skin pathology, in this study exemplified by IL-1α, IL-1RA, CXCL-1/2 and hBD-1, have potential as biomarkers for monitoring severity of disease, as well as for monitoring pharmacodynamic changes. Skin surface measurements of IL-1RA and CXCL-1/2 displayed a different profile than achieved by visual scoring of local inflammation or sonography, thus confirming that measuring the ‘molecular root’ of inflammation appears to have value as an objective, non-invasive biomarker measurement for scoring disease severity in its own right.

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High-frequency ultrasonography of psoriatic skin: A non-invasive technique in the evaluation of the entire skin of patients with psoriasis: A pilot study

Cited by 19 publications

References 17 publications

D‐chiro‐inositol as a treatment in plaque psoriasis: A randomized placebo‐controlled clinical trial

D‐chiro‐inositol as a treatment in plaque psoriasis: A randomized placebo‐controlled clinical trial

Imaging findings of Bowen's disease: A comparison between ultrasound biomicroscopy and conventional high‐frequency ultrasound

Evaluation of skin-surface interleukin 1 alpha, interleukin-1 Receptor Antagonist, CXCL-1/2 and beta-defensin-1 as non-invasive biomarkers for monitoring psoriasis vulgaris

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