Tissue fibroplasia, the combination of a biorevitalising mechanism with a biostimulant in a single mesotherapy preparation, is a relatively new group of injectable products. The study aimed to evaluate the effect of preparation with hyaluronic acid and sodium succinate on skin improvement in women with dry skin and clear signs of ageing. It showed a statistically significant decrease in skin echogenicity compared to the original state, an increase in skin thickness and a shallowing of individual wrinkles. Mesotherapy using the mechanism of tissue fibroplasia improves parameters of ageing skin, such as hydration level, thickness of the dermis, visibility of wrinkles, erythema, and skin discolouration.